Showing papers by "Loma Linda University published in 1969"
TL;DR: Food iron absorption could be predicted over the spectrum of normal to iron deficient states when these values were related to the absorption of ferrous ascorbate determined simultaneously in each subject.
236 citations
178 citations
83 citations
TL;DR: Plasma renin activity (PRA) and aldosterone excretion rate (AER) measurements were made during the first and third week of oral contraceptive pills (O.C.P.) and at the end of the week after discontinuing the O.P.
Abstract: Five normal subjects (total 15 subjects) were each given either Enovid-10, Orthonovum-10 or Provest. Plasma renin activity (PRA) and aldosterone excretion rate (AER) measurements were made during the first and third week of oral contraceptive pills (O.C.P.) and at the end of the week after discontinuing the O.C.P. Venous samples for PRA were obtained under 3 conditions: Condition 1, supine overnight and on unrestricted Na intake, Condition 2, supine overnight after 72 hr Na restriction (<10 mEq Na/24 hr), Condition 3, after Na restriction and standing 4 hr. Fifty-one per cent of the PRA and 23% of the AER values in the first week on the pills were greater than 2 sd above the normal mean. Thirty-three per cent of the PRA and 27% of the AER values during the third week of the pills were greater than 2 sd above the normal mean. The 8 subjects who had been taking O.C.P. for over 10 months prior to this study had a more pronounced effect than the 7 who had not previously taken O.C.P.
49 citations
TL;DR: Ethinyl estradiol manufactured 6–7 yr before use caused a greater effect on PRA values than did E.E. manufactured within a year before use, and Medroxyprogesterone acetate in doses of 20 mg daily for 3 weeks caused no apparent change in PRA.
Abstract: Ethinyl estradiol (E.E.) was given 0.5 rag daily for 3 weeks to 13 normal subjects. Plasma renin activity (PRA) was measured before and during the first and third week of E.E. with the subjects under 3 combinations of sodium intake and body posture. Aldosterone excretion rate (AER) was measured in association with the PRA under normal and low Na intake. There was a slight but statistically insignificant increase in PRA during the first week of E.E. administration. However, there was a significant (p 0.02 or lower) increase in PRA values under all 3 combinations of sodium intake and posture and a significant increase in AER under both normal and low Na intake during the third week of E.E. administration. E.E. manufactured 6–7 yr before use caused a greater effect on PRA values than did E.E. manufactured within a year before use. Medroxyprogesterone acetate (M.P.A.) in doses of 20 mg daily for 3 weeks caused no apparent change in PRA. It did cause a significant decrease in urinary AER in the third ...
37 citations
TL;DR: The effect of fluoride on the physical properties of bone was investigated with the aid of an Instron materials tester and a significant increase in flexibility in the rat femur was found only at the 45.0 ppm dosage level.
Abstract: The effect of fluoride on the physical properties of bone was investigated with the aid of an Instron materials tester. Two groups of weanling female rats, one on an adequate (0.6%) calcium diet and the other on a low (0.1%) diet were given the following dosage levels of fluoride (as NaF) in their deionized drinking water over a fifteen and one-half week period: 3.4 ppm, 10.0 ppm and 45.0 ppm. In the adequate calcium group a significant increase in flexibility in the rat femur was found only at the 45.0 ppm dosage level. This was not offset by a significant decrease in strength. In the low calcium group a similar significant increase in flexibility appeared at the 10.0 ppm dosage level as well as the 45.0 ppm, but a significant decrease in strength at the two dosage levels was observed. These were in direct relation to the amount of fluoride given.
37 citations
TL;DR: Gas-liquid chromatography was used to successfully separate certain pesticidal phenyl N-methylcarbamates from their phenolic moieties, with small amount of breakdown products observed.
22 citations
TL;DR: One hundred and thirty-eight molar pregnancies seen during a 15 year period at the Los Angeles County General Hospital are reviewed and a disparate number of hydatidiform moles occurring in the extremes of reproductive age is again noted.
15 citations
TL;DR: This rhythmic-arrhythmic system, with its abrupt transition, could prove of value in elucidating a mechanism or pathway involved in rhythmicity in Veromessor pergandei females.
15 citations
TL;DR: An epidermal extract prevents G1 cells from entering S phase and a stimulating factor that is heat-stable and non-dialyzable is also present in the epidersmal extract.
12 citations
TL;DR: It is concluded that the control mechanism for cell division has its greatest effect on G1 cells, which determines whether a G1 cell will begin preparation for DNA synthesis or enter a nondividing state (G0) by altering the differential gene expression of the cell.
14 May 1969
TL;DR: The method of text study followed by laboratory activity is essentially the same for both undergraduate and medical school students, and for the latter, a more comprehensive study of experimental animals is involved and surgical procedures are observed on patients.
Abstract: Medicine has developed current methods of teaching heart function over several centuries. There have been few fundamental changes in these teaching techniques over the last several decades. The method of text study followed by laboratory activity is essentially the same for both undergraduate and medical school students. For the latter, a more comprehensive study of experimental animals is involved, and surgical procedures are observed on patients. Once in medical school, almost all teaching is by demonstration, with a very small number of students per instructor.
TL;DR: Serum protein data appear to indicate a closer relationship between eremicus and interparietalis than is suggested by morphological characteristics, and protein patterns showed consistent interpopulation differences which tend to support current interpretations of the taxonomy of this group.
Abstract: The taxonomic relationship of Peromyscus eremicus, P. guardia, and P. interparietalis was investigated, using hybridization, morphological characters, and blood serum protein electrophoresis. Under laboratory conditions P. interparietalis ryckmani and P. eremicus bred readily, but P. guardia guardia did not breed. Peromyscus interparietalis ryckmani and P. eremicus hybridized freely, producing fertile hybrids, and P. guardia guardia and P. interparietalis ryckmani produced two litters of hybrids. The interparietalis X eremicus hybrid sex ratio was abnormal—19 males and seven females. Peromyscus interparietalis ryckmani and P. eremicus are morphologically distinct, and the hybrids between these populations are morphologically distinguishable from both parental populations, and exhibit heterosis. Blood serum proteins of eremicus, two subspecies of guardia, three subspecies of interparietalis, and hybrids between eremicus and P. interparietalis ryckmani were analyzed by cellulose acetate strip electrophoresis. The protein patterns showed consistent interpopulation differences which tend to support current interpretations of the taxonomy of this group. Serum protein data appear to indicate a closer relationship between eremicus and interparietalis than is suggested by morphological characteristics. Even though eremicus, guardia, and interparietalis are morphologically distinct, they have not diverged sufficiently to have developed mechanisms of intersterility.
TL;DR: Two female patients ages 35 and 31 years who had chief complaints of marked changes in weight with excess fluid retention were observed to remain edema-free on a low cellulose diet and on a cellulose-free diet, with water intake unrestricted and sodium intake 90–160 mEq./day.
Abstract: Two female patients ages 35 and 31 years who had chief complaints of marked changes in weight with excess fluid retention were observed to remain edema-free (patient M.H.) for over 5 weeks on a low cellulose diet and (patient E.H.) for 9 weeks on a cellulose-free diet, with water intake unrestricted and sodium intake 90–160 mEq./day. The administration of short-chained methylcellulose (Cologel® 30 ml. three times a day) resulted in a 14-lb. weight gain in 48 hours in patient M.H. and an 8-lb. weight gain in 24 hours in patient E.H. The excess fluid disappeared by 72 hours after the last dose of Cologel. Fluid retention was demonstrated on two occasions in both patients at different phases of the menstrual cycle. At the peak of fluid retention, the patients had visual aberrations, mental cloudiness, and poor coordination of some skeletal muscle actions. During administration of Cologel there was sodium and water retention, a 5–8 mOsm/Kg. increase in serum osmolality, and a 25–75 per cent decrease in urinary aldosterone excretion rate. Fluid retention could be prevented in patient E.H. on a selective diet containing some cellulose by restricting sodium to 25 mEq./day, or by restricting water intake to 500 ml./day. Patient E.H. had a 5-fold greater than normal increase in plasma renin activity in response to sodium restriction. Aldosterone excretion rate increased from 8.9 to 330−450 μ g. 24 hours with 3–4 days of sodium restriction. Free water clearance in patient E.H. was 25–50 per cent of normal. Reinstitution of cellulose-containing foods in the diet resulted in a return of the problem of fluid retention.
TL;DR: The antiviral effect demonstrated in this experiment when the cell system is pretreated prior to virus infection required the presence of the drug during the early stages of penetration of the cells by the virus particles.
Abstract: Cyclooctylamine and amantadine inhibit the growth of 1969 isolates of A2 influenza virus to a significant degree. There was slightly more inhibition of the virus by the cyclooctylamine (COA) than the amantadine; however, the dose of COA used was greater than the dose of amantadine. There was no significant difference between flasks treated 3 or 4 hr and those treated 2 hr. However, there was a curious relationship of more plaques in the flasks exposed to the two drugs for the longer intervals. Other experiments done with slight modifications in technique support the antiviral effect demonstrated in this experiment when the cell system is pretreated prior to virus infection. In two experiments, pretreating the cells for 2 hr with COA at 100 μg/ml but removing the drug solution and washing the cells prior to virus inoculation revealed no differences in plaque counts between controls and treated cells. This would indicate that the antiviral effect required the presence of the drug during the early stages of penetration of the cells by the virus particles.
01 Jan 1969
TL;DR: The administration of ethinyl estradiol increased plasma renin activity (PRA) and aldosterone excretion rate and her PRA decreased to normal after the oral contraceptive was discontinued.
Abstract: We have reported elsewhere (1) that the administration of ethinyl estradiol increased plasma renin activity (PRA) and aldosterone excretion rate. We were led to make these observations because of the findings of a markedly increased PRA in a normal subject who was taking Orthonovum for contraceptive purposes. Her PRA decreased to normal after the oral contraceptive was discontinued.