Showing papers by "Mangalayatan University published in 2010"

Antipsychotic activity of aqueous ethanolic extract of tinospora cordifolia in amphetamine challenged mice model.

Abstract: Tinospora cordifolia is reported to have CNS active principle and is used for the treatment of various neurological disorders. Hence, the effect of aqueous ethanolic extract of Tinospora cordifolia was investigated for its putative antipsychotic activity using amphetamine challenged mice model. Haloperidol (1 mg/kg i.p.) was administered acutely to mice as standard drug. Control animals received vehicle (10% DMSO). The in vivo receptor binding studies were carried out to correlate the antipsychotic activity of the extract with its capacity to bind to the DAD2 receptor. The results in SLA showed that the hydro alcoholic extract of the stems of Tinospora cordifolia at a dose level of 250 mg/kg and 500 mg/kg showed no significant antipsychotic activity in amphetamine induced hyperactivity in mice when compared to standard. Extract alone treated group at a dos level of 250 mg/kg and 500 mg/kg showed a decreased in locomotor activity when compared to the control. The plant extract increased the DAD(2) receptor binding in a dose dependent manner in treated mice compared to the control group.

Isolation and characterization of total volatile components from leaves of citrus limon linn.

Abstract: The isolation of the essential oil of whole fresh leaves of Citrus lemon by steam distillation is described. The chemical composition of the oil was investigated by means of Gas-Liquid Chromatography (GLC), Column Chromatography (CC) and coupled Gas Chromatography-Mass Spectrometry (GC-MS). The 27 most important volatile components were identified. The volatile components were identified by comparing their retention times of GC chromatograph with those of literature. Further identification was done by GC- MS. The components of the oil, percentage of each constituent, their RI values and their Eight Peak Index were also summarized and reviewed with standard available literature.

A comparative study of inclusion complexes of flunarizine with alpha (α-CD) and beta-cyclodextrin (β-CD)

Abstract: A detailed NMR (1H, COSY, and ROESY) spectroscopic study of complexation of Flunarazine (FL) with α- and β-CD was carried out. 1H NMR titration studies confirmed the formation of FL/α-CD and FL/β-CD complexes as evidenced by chemical shift variations of the proton resonances of both the CDs and FL. The stoichiometry of the complexes was determined to be 1:2 (FL/α-CD) and 1:1 (FL/β-CD) and overall binding constants were also calculated. It was confirmed with the help of ROESY spectral data that only one of the F-substituted aromatic ring and phenyl ring penetrate the α-CD cavity while both F-substituted aromatic rings as well as phenyl ring penetrates the β-CD cavity during complexation. The binding modes of FL/CD cavity interactions derived from ROESY experimental data show that the resulting complex of FL with β-CD possesses better induced fit interaction as compared to α-CD, which is responsible for the enhanced molecular stability with β-CD in comparison to α-CD. The mode of penetration of guest into the CD cavity and structures of the complexes has been established.

Coupling of the Solar Wind and the Magnetosphere

Abstract: The field orientation in transient and co-rotating structures that are ejected from the Sun and evolve in interplanetary space is crucial in reconnection between the solar wind and the magnetosphere. However, fluctuations in the magnetic field and/or enhancements in plasma density may influence the coupling between the solar, interplanetary, and magnetospheric fields. Consequently, the geo-effectiveness of solar wind structures with enhanced field variance and density are likely to increase. We study the effects of both enhanced field fluctuations and enhanced plasma density on the magnetic reconnection/coupling efficiency. We consider solar plasma and field properties, particularly the field fluctuation and plasma density before, during, and after the interplanetary events with geospace consequences. Considering the geo-effectiveness of different magnitude as a measure of the coupling efficiency and reconnection rate, we study the influence of these enhancements on the solar wind–magnetosphere coupling efficiency, during southward field orientation within the interplanetary structures.