Showing papers by "Manipal University published in 1992"
Journal Article•
TL;DR: Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7), has been studied for its induction of glutathione S-transferase activity in mice and depleted sulfhydryl levels in tissues, especially in stomach where 45% depletion was observed.
Abstract: Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7), has been studied for its induction of glutathione S-transferase activity in mice. At a dose of 250 mg/kg orally for 15 days, the enzyme activity in liver was increased by 1.8 fold. Its effect on other tissues like stomach, small intestine, lungs, kidney was not significant. Curcumin also depleted sulfhydryl levels in tissues, especially in stomach where 45% depletion was observed.
88 citations
TL;DR: Curcumin protects hemoglobin from nitrite‐induced oxidation to methemoglobin but this protection is not observed when curcumin is added after the autocatalytic stage of the oxidation of hemoglobin by nitrite.
54 citations
TL;DR: In this article, the authors used the extended Hildebrand solubility approach to process the data on paracetamol and found that the ratio of the ratio W and (log γ 2 )/A was approx. 13.40 H. The expression for W regression was satisfactory for the determination of the solubilities of paracetamide in methanol, ethanol and their mixtures, but deviated in the case of butanol and propanol.
35 citations
TL;DR: A series of substituted 3-(benzylideneamino) coumarins was synthesized and evaluated for anti-inflammatory activity against carrageenan-induced edema in rats but these derivatives were devoid of antipyretic activity and showed low activity against adjuvant-induced arthritis.
27 citations
Journal Article•
10 citations