Mbarara University of Science and Technology

About: Mbarara University of Science and Technology is a education organization based out in Mbarara, Uganda. It is known for research contribution in the topics: Population & Health care. The organization has 1145 authors who have published 1845 publications receiving 43184 citations.

Community perceptions about dementia in southwestern Uganda

Abstract: With the increasing number of people surviving into older age in Africa, dementia is becoming a public health concern. Understanding the social dynamics of dementia in resource-limited settings is critical for developing effective interventions. We explored community perceptions about people with dementia in southwestern Uganda. Fifty-nine individuals (aged 19–85 years, 56% female) participated in seven focus group discussions. In addition, 22 individual in-depth interviews were conducted among individuals (aged 22–84 years, 36% female). Both interviews and focus group discussions were audio recorded, transcribed verbatim, and evaluated using a quantitative content analysis approach. Five themes were generated during content analysis: i) Labeling of the illness, ii) Presentation of the person with dementia, iii) Causation, iv) Impact of the disease on people with dementia and their caregivers and v) Views on how to address unmet needs in dementia care. Dementia was commonly referred to as “okuhuga”or “okwebwayebwa” (also, oruhuzyo/ empugye / akahuriko) which translates as “mental disorientation”. The participants reported that most people with dementia presented with forgetfulness, defecating and urinating on themselves, wandering away from home, going out naked, and picking up garbage. Some participants perceived memory problems as a normal part of the aging process, while others attributed the cause of dementia to syphilis, cancer, allergy, old age, satanic powers, witchcraft, poor nutrition, or life stress. Participants reported multiple sources of stress for caregivers of people with dementia, including financial, social, and emotional burdens. Finally, participants suggested that community and governmental organizations should be involved in meeting the needs of people with dementia and their caregivers. Community members in southwestern Uganda largely identified dementia as a problem that comes with older age, and can identify key features of dementia presentation. Participants identified significant stressors affecting people with dementia and their caregivers, and reported that families and caregivers would benefit from education on the management of symptoms of dementia, and assistance in overcoming associated financial, social, and emotional burdens related to caretaking.

Mobility of chromium, copper and arsenic in amended chromated copper arsenate contaminated soils

Abstract: Aim: The use of copper-based preservatives such as chromated copper arsenate (CCA) and creosote to prolong the life of lumber present environmental concerns because they contain heavy metals and polycyclic aromatic hydrocarbons which are toxic to humans. The aim of this study was to investigate the effects of sewage sludge biosolid amendment on the distribution and mobility of chromium, copper and arsenic in chromated copper arsenate contaminated soils subjected to phytoremediation using maize (Zea mays L.). Place and Duration of the Study: Random composite soil samples from Kitetika wood factory, Wakiso, Uganda and sewage sludge biosolid from National Water and Sewerage Corporation plant in Bugolobi, Kampala, Uganda were collected and prepared. Maize grains were obtained from FICA Seeds Limited (Uganda). The pot experiments and analysis of samples were done at Mbarara University of Science and Technology (Mbarara) and Directorate of Government Analytical Laboratory, Kampala (Uganda), respectively. Methodology: The fresh CCA contaminated soils and sewage sludge biosolid were analyzed for physicochemical parameters and heavy metals (chromium, copper and arsenic). Sewage sludge biosolid was added to 1 kg of the contaminated soils at 5-25% (w/w) in 2 L plastic containers, watered and maintained at 25 ℃ for 14 days to stabilize. Controls were set up with unamended soils. Thereafter, maize was planted in the potted soils for 40 days. The concentrations of the trace metals in the soils were determined after 20 and 40 days of maize growth by atomic absorption spectroscopy. Results: The concentrations of chromium, copper and arsenic in fresh CCA contaminated soils were 365.8 ± 6.18 mg/kg, 109.72 ± 14.04 mg/kg and 28.22 ± 3.8 mg/kg, respectively. Basing on mobility factor, bioavailability of the trace metals followed the chemical sequence copper (8.9%) < chromium (17.1%) < arsenic (30.2%). Conclusion: The maize variety experimented could be used to phytoextract or phytostabilize the trace metals in the CCA contaminated soils without or with 5-25% amendment. Amendment with sewage sludge biosolid improved the phytoremediation potential of maize. Arsenic was the most mobile and bioavailable metal in CCA contaminated soils. Further studies should use other local maize varieties such as Longe series.

Delusional ideation and manic symptoms in potential future emigrants in Uganda

Abstract: Background. The cause of increased schizophrenia rates among immigrants in Europe is unknown. This study explores psychotic features in persons aspiring and actively planning to emigrate, prior to their potential emigration. Method. Potential future emigrants and controls in Kampala (Uganda) were screened for delusional ideation and manic symptoms, using the Peters et al. Delusions Inventory (PDI) and mania items from the Composite International Diagnostic Interview (CIDI). Results. Aspirations regarding emigration were associated with increased delusional ideation compared with controls (p = 0·01), whereas active plans regarding emigration were not. Neither aspiring nor actively planning to emigrate was associated with increased manic symptoms. Subjects with increased delusional ideation also had increased manic symptoms (p < 0·001). Conclusions. Although some aspects of delusional ideation might include thoughts concerning emigration, practical circumstances (e.g. visa requirements, travel costs) probably prevent emigration of the psychosis-prone in many settings. (Less)

Prevalence and bacteriology of culture-positive urinary tract infection among pregnant women with suspected urinary tract infection at Mbarara regional referral hospital, South-Western Uganda

Abstract: Urinary tract infections (UTIs) in pregnant women contribute about 25% of all infections and are among the most frequent clinical bacterial infections. Pregnancy changes in women that include anatomical, physiological and hormonal make them susceptible to develop UTI. Left untreated, UTI in pregnancy is associated with grave complications to the mother and fetus. These complications can be decreased by prompt and proper diagnosis and appropriate treatment that also reduces the emergency of drug resistance. Antimicrobial resistance is a major health problem in the treatment of UTI. We determined the prevalence, bacteriology and antimicrobial susceptibility of symptomatic urinary tract infection among pregnant women at Mbarara Regional Referral Hospital. We conducted a cross-sectional study from November 2019 to February 2020 involving 400 pregnant women with symptomatic UTI. Patient information was obtained using a structured questionnaire. We collected clean-catch midstream urine specimens for culture and performed antimicrobial susceptibility testing following Clinical and Laboratory Standards Institute standards. Data was entered into RED-cap Version 8.2 software and then exported to Stata Version 14.1 for analysis. The proportion of culture-positive UTI was 140/400 (35%). Gram-negative bacteria were more prevalent (73%): Klebsiella pneumoniae 52(37.41%), Escherichia coli 40(28.78%), Pseudomonas aeruginosa and Proteus mirabilis 7(5.04% each), Citrobacter freundii 1(1%). Staphylococcus aureus 33(23.57%) was the only gram-positive isolate. All the isolates were resistant to ampicillin, amoxicillin, amoxicillin/clavulanic acid and ceftazidime/clavulanic acid (95.7, 95.0, 72.9 and 50.7% respectively). Prevalence of extended-spectrum beta-lactamases producing Enterobacteriaceae was 29.0% while that of methicillin-resistant Staphylococcus aureus was 33.3%. All cultures demonstrated resistance to more than one drug. Majority of the bacterial isolates were sensitive to ciprofloxacin, ceftriaxone, nitrofurantoin, cefotaxime and gentamicin at 82.9, 81.4, 79.3, 78.6, 66.4 and 65.7% respectively. Klebsiella pneumoniae was the most prevalent isolate followed by E. coli. These two organisms were highly resistant to the commonly used antibiotics. Our study recorded a higher prevalence of culture-positive UTI in pregnancy than all the studies in Uganda. Empirical treatment of UTI should be minimized as sensitivity varies for each organism, for each drug and over time.

A Controlled Pre-Post Evaluation of a Computer-based HIV/AIDS Education on Students’ Sexual Behaviors, Knowledge and Attitudes

Abstract: Unlike traditional approaches to sexuality and HIV education which can be constrained by the sensitive nature of the subject, Information Technology (IT) can be an innovative teaching tool that can be used to educate people about HIV. This is especially relevant to interventions targeting young people; the population group fond of using IT, and the same group that is more vulnerable to HIV/AIDS. Yet, there are significantly few empirical studies that rigorously evaluated computer-assisted school-based HIV/AIDS interventions in developing countries. The modest studies conducted in this area have largely been conducted in developed countries, leaving little known about the effectiveness of such interventions in low resource settings, which moreover host the majority of HIV/AIDS infections. This research addresses this gap by conducting a controlled before-after intervention evaluation of the impacts of the World Starts With Me (WSWM), a computer-assisted HIV/AIDS intervention implemented in schools in Uganda. The research question was: did the WSWM intervention significantly influence students’ sexual behaviours, HIV/AIDS knowledge, attitudes and self-efficacy? To address this question, questionnaires were simultaneously administering to 146 students in an intervention group (the group receiving the WSWM intervention) and 146 students in a comparison group (the group who did not receive the WSWM intervention), before (February 2009) and after the intervention (December 2009). Findings indicate that the intervention significantly improved students’ HIV/AIDS knowledge, attitudes self-efficacy, sex abstinence and fidelity, but had no significant impact on condom use. The major reason for non-use of condoms was lack of knowledge about condom use which can be attributed to teachers’ failure and inabilities to demonstrate condom use in class. To address this challenge, intervention teachers should be continuously trained in skills-based and interactive sexuality education. This training will equip them with self-confidence and interactive teaching skills, including tactics for emphasing building students’ skills through role plays and interactive assignments. In addition, the HIV interventions themselves should include interactive virtual condom use demonstrations that can be accessed by students themselves. Key words: ICT for HIV/AIDS; WSWM; HIV/AIDS behaviours, knowledge and attitudes; students.