Showing papers by "North Bengal Medical College published in 2005"

A 5 years prospective study of incidence, morbidity and mortality profile of stroke in a rural community of eastern India.

Abstract: Community-based longitudinal study on stroke is rare in India It has been predicted that the stroke incidence will be higher in developing countries than developed countries Hence a five years prospective study was planned to carry out in the rural Bengal, India based on WHO protocol to determine the incidence rate, risk factors, morbidity and mortality profile of stroke In a two-stage procedure, 20717 subjects out of 20842 people from a cluster of 12 villages was surveyed by house-to-house method and the screened cases were examined by a team of neurologists including post stroke surveillance for one year Altogether 128 first ever stroke cases were detected over 5 years showing an average annual incidence rate of 12357 per 100,000 persons [age adjusted incidence rate (AAIR)--262/100,000; based on USA population, 1990] and sex-specific AAIR (274/100,000) among women is slightly higher than men (253/100,000) Age-specific stroke incidence rate showed increasing rate from fourth decade up to seventh decade in both sexes when the rate was maximum First 30 days mortality recorded was 18% with men suffering twice than women Follow-up after one year revealed speech improvement in 47%, residual spasticity in 46% and independency in activities daily living in 62% of cases Age and sex matched case control study has shown that hypertension (OR - 279), heart disease (OR - 620) and smoking (OR - 392) are significant risk factors This study had indicated a higher age adjusted incidence rate of stroke in India as compared to that of developed country and hypertension, heart disease and smoking are important risk factors

Hepatic tuberculosis mimicking carcinoma gall bladder.

Abstract: An 11-month-old girl child presented with distension of abdomen, constipation, vomiting and fever. X-ray of the abdomen suggested intestinal obstruction. Exploration revealed the distal ileum to be kinked around a band running from the tip of a congested Meckel's diverticulum to the lateral pelvic wall. A small perforation was noticed at the tip of the diverticulum and a live roundworm was found lying free in the peritoneal cavity. The diverticulum along with a segment of adjoining bowel was resected and end-to-end anastomosis done. The diverticulum had a wide lumen and showed no heterotopic tissue on subsequent examination.

Risk factors for coronary heart disease in Indians: a case-control study from Eastern India.

Abstract: We conducted a hospital-based case-control investigation (150 cases and 176 controls) to examine the putative role of conventional risk factors in subjects with and without coronary heart disease from Eastern India. Multivariate binary logistic regression revealed the following as significant risk factors for coronary heart disease: male sex (OR = 4.6, p = 0.001), elevated total cholesterol/high-density lipoprotein ratio (OR = 4.0, p = 0.001), systolic blood pressure (OR = 3.0, p = 0.004), diastolic blood pressure (OR = 3.6, p = 0.002), fasting plasma glucose (OR = 3.0, p = 0.05), post-pondrial plasma glucose (OR = 3.2, p = 0.005), Impaired fasting glucose (OR = 3.7, p = 0.002), elevated triglyceride (OR = 3.1, p = 0.018), increased total cholesterol (OR = 3.0, p = 0.029), low-density lipoprotein (OR = 3.1, p = 0.001), low-density lipoprotein/high-density lipoprotein ratio (OR = 3.4, p = 0.004), central obesity (OR = 3.0, p = 0.006), smoking (OR = 3.7, p = 0.001) and urban residence (OR = 3.1, p = 0.003). In this study, the discriminant analysis showed that 77.2% of all entry for cases and 72.6% of all entry for controls were correctly classified using conventional risk factors and warrant early intervention for conventional risk factors.

A Study of HLA-Linked Genes in a Monosymptomatic Psychotic Disorder in an Indian Bengali Population

Abstract: 269 Objective: The etiology of delusional disorder is imperfectly understood. Involvement of biological factors has long been suspected.We examined the incidence of class I human leukocyte antigens (HLAs) in patients with delusional disorder to understand the role of HLA genes and explore a possible immunogenetic etiology for delusional disorder. Methods: We used a nested case–control study design. Psychiatric reference data were available for 27 500 patients registered between 1998 and 2003. Initially, we enrolled 150 patients with delusional disorder from the India-born Bengali population, using DSM-IV diagnostic criteria. After longitudinal follow-up, 80 patients were found to have only delusional disorder, while the remaining 70 patients represented different illnesses with paranoid symptoms and were excluded. We performed serological typing on all 150 patients and applied the polymerase chain reaction–based high-resolution molecular typing method to the 80 patients with delusional disorder. Eighty healthy donors of the same ethnic background, matched for age, sex, and other socioeconomic variables, formed the control group. Results: Some of the HLA alleles were associated with delusional disorder, and the gene HLA-A*03 was found to be significantly more frequent. This gene may influence patients’ susceptibility to delusional disorder.

Study of HLA-Linked Genes in Paranoid Schizophrenia in an Indian Bengalee Population

Abstract: Schizophrenia is a major psychotic disorder with a strong genetic component and molecular etiology remains enigmatic. They form a heterogeneous and poorly understood collection of disorders of which Paranoid Schizophrenia is the best diagnosed and least severe clinical subtype of Schizophrenia. Involvement of biological factors has been suspected for long. In the present investigation, the incidence of HLA Class-I antigens has been studied to understand the role of HLA genes in the patients with paranoid schizophrenia with the objectives to explore a possible immunogenetical etiology of paranoid schizophrenia. A case-control study design was performed. Psychiatric reference data were available for total number of 30,000 cases attended between 1998 and 2004. A total number of 120 patients with paranoid schizophrenia belonging to the India born Bengalee population were initially enrolled for the study and DSM-IV criteria was used for the diagnosis of the patients. Upon longitudinal follow up 70 patients turned out to be the cases of other psychotic conditions and PCR-based molecular typing (PCR-SSP) method was applied to 50 genuine cases of Paranoid Schizophrenia. A total numbers of 100 healthy donors belonging to the same ethnic background were considered as controls. The present investigation shows that some of the HLA antigens are associated with paranoid schizophrenia and especially significant increases are found for HLA-A*03 gene which may influence susceptibility to paranoid schizophrenia. The study reveals important interactions between HLA genes and paranoid schizophrenia. This preliminary observation may help to understand the etiological basis of this disorder.

Dermoid cyst of the mesentery in an infant

Abstract: 7 months old male child presented with abdominal distension since birth On examination there was a lobulated, tense cystic mass occupying almost 2/3 of the abdominal cavity Ultrasonography (USG) revealed a predominantly hypoechoic mass measuring 17cm x 14cm x15cm CT scan of abdomen showed a multiseptate cystic mass with eccentrically located areas of fat and calcification Exploration of the abdomen revealed a huge thick walled cyst within the leaves of the mid ileal mesentery which could be enucleated out entirely after careful dissection Histopathology suggested it to be a benign cystic teratoma (Dermoid cyst)

Gigantic post-traumatic pseudocyst of sigmoid mesentery.

Abstract: A 29-year-old man presented with dull abdominal pain and a lump occupying almost the entire abdomen, four months after a fall from a height. Ultrasonography revealed a cystic lesion with debris occupying almost the entire abdomen. Diagnostic tap revealed brownish fluid. Exploration revealed a huge thick-walled cyst of the sigmoid mesocolon, which could be enucleated out entirely. Histology suggested it to be a false cyst.