Showing papers by "Saskatchewan Health published in 1999"

Incidence of lactic acidosis in metformin users.

Abstract: OBJECTIVE: The purpose of this study was to determine the incidence of lactic acidosis in a geographically defined population of metformin users. RESEARCH DESIGN AND METHODS: The study was based on a historical cohort from the Saskatchewan Health administrative databases. Individuals with a metformin prescription dispensed between 1980 and 1995 inclusive were eligible for the cohort. Person-years of exposure were calculated. Cases were defined by hospital discharge with a diagnosis of acidosis (International Classification of Diseases, Ninth Revision code: 276.2) and confirmation by chart review of a blood lactate level > or = 5 mmol/l. Death registrations of individuals dying within 120 days of a metformin prescription were also reviewed. RESULTS: During the study period, 11,797 residents received one or more metformin prescriptions, resulting in 22,296 person-years of exposure. There were 10 subjects who had hospital discharges with a diagnosis of acidosis. However, primary record review revealed only two cases with laboratory findings of elevated blood lactate levels, for an incidence rate of 9 cases per 100,000 person-years of metformin exposure. In both cases, other factors besides metformin could have contributed to the lactic acidosis. No additional cases were found on review of death registrations. CONCLUSIONS: From 1980 through 1995, the incidence rate of lactic acidosis was 9 per 100,000 person-years (95% CI 0-21) in patients dispensed metformin in Saskatchewan, Canada. This incidence rate was derived from a population with complete ascertainment of hospitalizations and deaths associated with lactic acidosis in metformin users. It is similar to previously published rates based on passive reporting of cases, and it is well below the lactic acidosis rate of 40-64 per 100,000 patient-years in patients prescribed phenformin.

Arsenic in Well Water Supplies in Saskatchewan

Abstract: Arsenic is the twentieth most abundant element found in the earth’s crust and is usually present in the form of various sulphides and oxides. It is found in numerous ores and minerals. Arsenic may also be found in trace levels in virtually all living matter. Industrial uses of arsenic compounds include the manufacturing of transistors and semi-conductors, wood preservatives, pesticides, and veterinary drugs.

Applying a population health approach.

Abstract: While concepts that underlie good public health and population approaches to health go back a long way, renewed recognition that health is dependent on more than the ability to treat has given new impetus to a more comprehensive approach to thinking about and planning for health and human services. This paper offers a reflection on how we conceptualize population approaches to health. Recognizing our current understanding of health determinants and dynamics, the paper explores moving from "avoiding disease" to to "pursuing health." It then examines the pragmatic balancing act of science, art, beliefs and politics, with attendant traps. It concludes with a way of framing action on population health and translating theory into practice.

Determination of pentachlorophenol in human urine using solid phase extraction and GC‐MS analysis with stable isotope dilution

Abstract: A method for the determination of pentachlorophenol (PCP) in human urine was developed. Urine samples were fortified with 13C6‐IabeIed PCP and hydrolyzed with sulfuric acid prior to extraction. The urine samples were then passed through preconditioned solid phase extraction cartridges containing octadecylsilane adsorbent. The PCP was subsequently eluted from the cartridge with ethyl acetate and converted to pentachloroanisole prior to GC‐MS analysis. GC‐MS quantitation was performed using the technique of stable isotope dilution. Percent recoveries averaging 100, 97, and 111% were obtained for replicate urine samples fortified with approximately 2, 20, and 200 ng/mL of PCP, respectively. The method detection limit was estimated to be 0.2 ng/mL.