Showing papers by "Suffolk University published in 2022"

Training load responses to football game profile-based training (GPBT) formats: effects of locomotive demands manipulation

Abstract: The aim of this study was to compare internal and external load profiles of different game profile-based training (GPBT) formats among elite young football players. Twenty-one participants (age: 18.7 ± 0.6 years) performed three sessions of three GPBT formats, which were matched for training volume but structured with different high-speed running and sprint demands: i) performed along linear paths (GPBT-L); ii) performed as repetitive actions of short distance including many multi-directional changes of direction (GPBT-S) and, iii) a combination of the other two protocols, that is linear high-speed runs and sprint efforts with a single change of direction (GPBT-M). External load outputs were collected using GPS units, physiological and perceptual responses were monitored with heart rate (HR) monitors, and ratings of perceived exertion (RPE), respectively. While no differences were found between formats for HR and RPE, distinct external load profiles were observed for high-speed running (HSD) and sprint distances (SD), (GPBT-L > GPBT-M > GBPT-S, all p GPBT-M > GPBT-L, all p < 0.05). Moreover, the GPBT-S format was characterized by greater intra-session variability for HSD, SD, and HIE (CV% = 24.2%, 16.5% and 20.4%, respectively) and inter-session variability for HSD and SD (CV% = 10% and 15.7%, respectively) compared to the other two formats. Considering their load profiles and the associated reliability scores, football practitioners can implement GPBT formats interchangeably to elicit necessary internal load responses and selectively to prioritize specific external load outputs.

German Pharmaceutical Pricing: Lessons for the United States:

Abstract: To control pharmaceutical spending and improve access, the United States could adopt strategies similar to those introduced in Germany by the 2011 German Pharmaceutical Market Reorganization Act. In Germany, manufacturers sell new drugs immediately upon receiving marketing approval. During the first year, the German Federal Joint Committee assesses new drugs to determine their added medical benefit. It assigns them a score indicating their added benefit. New drugs comparable to drugs in a reference price group are assigned to that group and receive the same reimbursement, unless they are therapeutically superior. The National Association of Statutory Health Insurance Funds then negotiates with manufacturers the maximum reimbursement starting the 13th month, consistent with the drug's added benefit assessment and price caps in other European countries. In the absence of agreement, an arbitration board sets the price. Manufacturers accept the price resolution or exit the market. Thereafter, prices generally are not increased, even for inflation. US public and private insurers control prices in diverse ways, but typically obtain discounts by designating certain drugs as preferred and by restricting patient access or charging high copayment for nonpreferred drugs. This article draws 10 lessons for drug pricing reform in US federal programs and private insurance.

Critiques of Violence

Abstract: This article surveys critiques of violence, including religious critiques (including Ancient Greek religion, Judaism, Christianity, Islam, Confucianism, Taoism, Hinduism, Buddhism, and Jainism); philosophical critiques (including Socrates, social contract theorists, and Kant); political and cultural critiques (including modern peace movements, workers movements, civil disobedience, feminism, environmentalism and animal rights, indigenous peoples' movements, and critiques of technological development). Topics include the nature and scope of violence; conceptions of just war; the extent and limits of various critiques; how violence affects the individual and society; modes of action to reduce violence, such as religious practices, civil disobedience, and political nonviolence.

Developing Tomorrow's mRNA-Based Therapies

Abstract: Genetic Engineering & Biotechnology NewsVol. 42, No. S2 mRNA Ready to Make Its MarkDeveloping Tomorrow's mRNA-Based TherapiesNew technologies—such as circular mRNA, self-amplifying mRNA, programmable mRNA, and Cas13-encoding mRNA—point to more powerful mRNA-based treatmentsMike May, PhDMike May, PhDSearch for more papers by this authorPublished Online:9 Jun 2022https://doi.org/10.1089/gen.42.S2.01AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 42Issue S2Jun 2022 Information© 2022 by GEN PublishingTo cite this article:Mike May, PhD.Developing Tomorrow's mRNA-Based Therapies.Genetic Engineering & Biotechnology News.Jun 2022.4-7.http://doi.org/10.1089/gen.42.S2.01Published in Volume: 42 Issue S2: June 9, 2022PDF download

Corrective Lens: Dis/abilities and the Materiality of Media

Abstract: Lee asks media studies scholars to look beyond representations of dis/abilities and media accessibility by paying more attention to the relationship between the body and technologies. One way to do this is to examine how the materiality of technologies actively shapes the body, in particular how technical devices normalize non-normative bodies. She looks at two assistive technological devices—eyeglasses and Google Glass—and describes them as forms of media that enable users to experience the world beyond their immediate spatial and temporal limits. In this case, assistive technology does not simply remedy a body of defect, but it actively shapes, molds, and trains the body. Technologies challenge bodily limits and call into question what bodily normalcy is. For Lee, both medical and social constructionist models subscribe to a linear time-space or uni-dimensional vector in which accretions of knowledge and attitudinal change advance the human race. Lee argues instead that an embodiment-focused approach acknowledges social construction as well as shows technologies create different spaces and times for human experience.

Inflammation

Abstract: Understanding the role of inflammation as a function of clinical disease is required for the design of treatment modalities and the development of therapeutics. Inflammation is an essential component critical for everyday health and immune homeostasis, without which the body cannot discern regular biological turnover and events from outside harmful interference. The processes involved in the inflammatory response are examined, with emphasis on defining the cellular players and chemical mediators involved. A historical definition of inflammation is provided, followed by descriptive elements of inflammatory danger signals. Cellular players involved in the inflammatory reactions are then introduced, followed by a discussion of innate and adaptive mediators. While the primary focus is to understand innate inflammation, consequences of hypersensitive inflammation are also briefly discussed. The information provides an overview of the complex processes of inflammation that form the underlying basis for unique organ-specific pathologies.

Circulating Tumor DNA is Increasingly Effective in Cancer Healthcare

Abstract: Inside Precision MedicineVol. 9, No. 2 CtDNA and CancerCirculating Tumor DNA is Increasingly Effective in Cancer HealthcarectDNA can be used in early detection, treatment selection through noninvasive profiling, and understanding relapse after treatment.Mike MayMike MayMike May, is a freelance writer and editor with more than 30 years of experience. He earned an M.S. in biological engineering from the University of Connecticut and a PhD. in neurobiology and behavior from Cornell University. He worked as an associate editor at American Scientist, and he is the author of more than 1,000 articles for clients that include GEN, Nature, Science, Scientific American and many others. In addition, he served as the editorial director of many publications, including several Nature Outlooks and Scientific American Worldview.Search for more papers by this authorPublished Online:14 Apr 2022https://doi.org/10.1089/ipm.09.02.02AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 9Issue 2Apr 2022 InformationCopyright © GEN PublishingTo cite this article:Mike May.Circulating Tumor DNA is Increasingly Effective in Cancer Healthcare.Inside Precision Medicine.Apr 2022.6-8, 10.http://doi.org/10.1089/ipm.09.02.02Published in Volume: 9 Issue 2: April 14, 2022PDF download

Incompressible limit of Euler equations with damping

Abstract: <abstract><p>The Cauchy problem for the compressible Euler system with damping is considered in this paper. Based on previous global existence results, we further study the low Mach number limit of the system. By constructing the uniform estimates of the solutions in the well-prepared initial data case, we are able to prove the global convergence of the solutions in the framework of small solutions.</p></abstract>

Gang Responses

Abstract: An emerging shift in research and practice with gangs, gang members, and the violence they cause is integrating criminal justice and public health perspectives. While criminal justice approaches address gangs, crime, and violence, a public health approach involves tackling gang problems holistically recognizing the interplay between structural, relational, and individual-level factors. These include the structural conditions that give rise to street gangs as well as group and sociocognition factors for gang joining and gang violence. Current responses to street gangs are examined in this chapter along with empirical evidence on the success of these responses. Utilizing a public health perspective, responses are mapped according to primary, secondary, and tertiary prevention. Gaps are identified and shared themes across policies and programs are described. In short, most policies are aligned with a deep-end criminal justice approach to quarantining and stopping the spread of violence, while many programs are beginning to address the victim–offender overlap and group dynamics of gangs to affect change. Largely absent from policies and programs are recognition and attention to the root causes of gangs, gang joining, and gang violence. The chapter concludes by outlining future directions for policy, practice, and applied research on gangs and gang members.

Institutions and Institutionalism

Abstract: In common usage, many different things are called institutions: private property, marriage, the common law, the US Dollar, the UK Constitution, The African Union, the KMT political party of Taiwan, UNICEF, local-funding of primary schools, the corporation, the “Blue Line of Silence” among police, the New York Times, and – of course – Turtle Swamp Brewery in Jamaica Plain.

Wideman, John Edgar

Abstract: John Edgar Wideman grew up a first-hand witness to the conditions of the so-called urban ghettos of the 1950s and 1960s. His initial response to the blight, neglect, and decline he saw in Homewood – his Pittsburgh neighborhood – was not to immerse himself in it as his contemporaries in the Black Arts Movement did, but rather to remove himself physically, emotionally, and aesthetically. In his early work Wideman did not look directly to Homewood or to his family's stories for inspiration. Once he did, beginning in 1981, he became the leading literary voice regarding mass incarceration that has come to dominate discourse about race in America. Wideman might best be described as a post-Black Arts Movement writer who was aware of that movement's concerns, yet not a full participant in them. He forged a unique path that makes his work and career difficult to classify even as critics hail his undeniable importance. His long and varied career has blurred the lines between fiction and nonfiction, scrutinized the troubled ethics of writing about family, and merged esoteric ideas and popular cultural expressions to create a new literary aesthetic.

An Approach to a Patient with Joint Pain

Abstract: Joint pain is a common presenting symptom in primary care. It is important to have a structured and efficient approach to the history and examination of patients with musculoskeletal disease. This chapter provides an approach that will enable the clinician to arrive at a differential diagnosis by utilising a systematic approach. The general rheumatological history is discussed, followed by a more specific enquiry focused on individual presentations for patients with mechanical joint pain, connective tissue disease and inflammatory arthritis. A diagnostic tree is used to aid decision-making. The principles of general and localised examination are also explored.