Thomas Jefferson University Hospital

About: Thomas Jefferson University Hospital is a healthcare organization based out in Philadelphia, Pennsylvania, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 6173 authors who have published 7631 publications receiving 197620 citations.

Periprosthetic infection due to resistant staphylococci: serious problems on the horizon.

Abstract: Prosthetic joint infections (PJI) caused by methicillin-resistant staphylococci represent a major therapeutic challenge We examined the effectiveness of surgical treatment in treating infection of total hip or knee arthroplasty caused by methicillin-resistant staphylococcal strains and the variables influencing treatment success One hundred and twenty-seven patients were treated at our institution between 1999 and 2006 There were 58 men and 69 women, with an average age of 66 years Patients were followed for a minimum of 2 years or until recurrence of infection Debridement and retention of the prosthesis was performed in 35 patients and resection arthroplasty in 92 Debridement controlled the infection in only 37% of cases whereas two-stage exchange arthroplasty controlled the infection in 75% of hips and 60% of knees Preexisting cardiac disease was associated with a higher likelihood of failure to control infection in all treatment groups Antibiotic-resistant Staphylococci continue to compromise treatment outcome of prosthetic joint infections, especially in patients with medical comorbidities New preventive and therapeutic strategies are needed

Outcome Prediction in Patients with Glioblastoma by Using Imaging, Clinical, and Genomic Biomarkers: Focus on the Nonenhancing Component of the Tumor

Abstract: In the current study, we focused on the role of the nonenhancing region (NER) of glioblastomas and showed that there are imaging phenotypic features related specifically to the NER—most notably the NER crossing the midline and relative cerebral blood volume of NER, which provide important prognostic information; these are complementary to clinical and genomic features and can improve models of patient prognosis.

Rotator cuff tears: prospective comparison of MR imaging with arthrography, sonography, and surgery.

Abstract: Thirty-eight patients with suspected rotator cuff tears were examined at 1.5 T by using a loop-gap resonator surface coil. The MR findings were compared prospectively in a blinded fashion with the results from double-contrast arthrography in all 38 patients, high-resolution sonography in 23 patients, and surgery in 16 patients. In the total group of 38 patients, MR imaging detected 22 of 22 tears and 14 of 16 intact cuffs as determined by arthrography. In the 16 surgically proved cases, MR and arthrography showed identical results, with 92% sensitivity in the diagnosis of 12 tears and 100% specificity in the diagnosis of four intact cuffs. In a subgroup of 23 patients, sonography detected nine of 15 tears and seven of eight intact cuffs as determined by comparison with arthrography. In 10 surgically proved cases, sonography was 63% sensitive in the diagnosis of eight rotator cuff tears and 50% specific in the diagnosis of two intact cuffs. For the diagnosis of rotator cuff tears, MR imaging is comparable to arthrography in both sensitivity and specificity. In this study, sonography was not as accurate in the diagnosis of rotator cuff tears as were the other two techniques. These results suggest that MR imaging should be considered the noninvasive test of choice for patients with suspected rotator cuff disease.