Showing papers by "Torrey Pines Institute for Molecular Studies published in 1977"
TL;DR: Geldanamycin, an ansamycin antibiotic having anti-oncornavirus properties, was shown to completely inhibit the induction of measurable endogenous rat leukemia virus by 5-iodo-2′-deoxyuridine in a cell line of Fischer rat embryo cells and to protect the same cells from transformation by the polycyclic hydrocarbon 3-methyl-cholanthrene.
Abstract: SummaryGeldanamycin, an ansamycin antibiotic having anti-oncornavirus properties, was shown to completely inhibit the induction of measurable endogenous rat leukemia virus by 5-iodo-2′-deoxyuridine in a cell line of Fischer rat embryo cells and to protect the same cells from transformation by the polycyclic hydrocarbon 3-methyl-cholanthrene. Protection was induced at a dosage that was not only non-toxic but slightly stimulatory to cell growth.The authors wish to thank R. J. Huebner, A. E. Freeman, and E. A. Gregory for their assistance in the preparation of this manuscript.
9 citations
TL;DR: These results represent the most complete solution to date for the zero crossing statistics of any nontrivial random process.
7 citations