scispace - formally typeset
Search or ask a question

Showing papers by "University of Arkansas for Medical Sciences published in 2023"


Journal ArticleDOI
TL;DR: A systematic literature review of publications from 1990-2022 in PubMed, EMBASE, ClinicalTrials.gov, Ovid MEDLINE, Cochrane CENTRAL, and google scholar for studies evaluating AGV and BGI in childhood glaucoma was performed by as mentioned in this paper .
Abstract: To evaluate the outcomes and safety of Ahmed glaucoma valve (AGV) and Baerveldt glaucoma implant (BGI) in childhood glaucoma.We performed a systematic literature review of publications from 1990-2022 in PubMed, EMBASE, ClinicalTrials.gov, Ovid MEDLINE, Cochrane CENTRAL, and google scholar for studies evaluating AGV and BGI in childhood glaucoma. Primary outcome measures were intraocular pressure (IOP) reduction and glaucoma medication reduction. The secondary outcome measures were the sucess rates and incidence of postoperative complications. We conducted meta-analysis using a random effects model.Thirty-two studies met the inclusion criteria. A total of 1480 eyes were included. The mean IOP reduction was 15.08 mmHg ( P <0.00001) for AGV and 14.62 ( P <0.00001) for the BGI group. The mean difference between pre-and post-operative glaucoma medications was 1 ( P <0.00001) fewer medications in the AGV group and 0.95 ( P <0.0001) fewer medications in the BGI group. There was a lower success rate in the AGV vs. BGI groups at 2 years (63% vs. 83%, respectively ( P <0.0001)) and 3 years (43% vs. 79%, respectively ( P <0.0001)); however, the sucess was higher for AGV at 5 years (63% vs. 56% in the BGI group, P <0.001). The incidence of postoperative complications was comparable in the AGV and BGI groups, with rates of 28% and 27%, respectively.The IOP and glaucoma medication reduction, success rates, and incidence of postoperative complications were comparable in both groups. Most literature comes from retrospective low-quality studies on refractory childhood glaucoma. Further larger cohort studies are needed.

1 citations


Journal ArticleDOI
TL;DR: In this paper , the backward stepping response in early-stage Parkinson's disease was quantifiable, reproducible, and related to disease severity and could be used to quantify progression towards postural instability.

Posted ContentDOI
31 May 2023
TL;DR: In this article , the authors used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security among individuals ages ≥18 years who reported a cancer diagnosis from a health professional.
Abstract: <div>AbstractBackground:<p>Some cancer survivors experience medical financial hardship, which may reduce their food security. The purpose of this study was to explore whether medical financial hardship is related to food security among cancer survivors.</p>Methods:<p>The study was based on cross-sectional data from the 2020 National Health Interview Survey. We used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security (i.e., high, marginal, low, or very low) among individuals ages ≥18 years who reported a cancer diagnosis from a health professional (<i>N</i> = 4,130).</p>Results:<p>The majority of the sample reported high household food security (88.5%), with 4.8% reporting marginal, 3.6% reporting low, and 3.1% reporting very low household food security. In the adjusted model, the odds of being in a lower food security category were higher for cancer survivors who had problems paying or were unable to pay their medical bills compared with those who did not [OR, 1.73; 95% confidence interval (CI), 1.06–2.82, <i>P =</i> 0.027], who were very worried about paying their medical bills compared with those who were not at all worried (OR, 2.88; 95% CI, 1.64–5.07; <i>P</i> < 0.001), and who delayed medical care due to cost compared with those who did not (OR, 2.56; 95% CI, 1.29–5.09; <i>P =</i> 0.007).</p>Conclusions:<p>Food insecurity is rare among cancer survivors. However, medical financial hardship is associated with an increased risk of lower household food security among cancer survivors.</p>Impact:<p>A minority of cancer survivors experience medical financial hardship and food insecurity; social needs screenings should be conducted.</p></div>

Posted ContentDOI
31 May 2023
TL;DR: In this article , the authors used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security among individuals with cancer diagnosis from a health professional.
Abstract: <div>AbstractBackground:<p>Some cancer survivors experience medical financial hardship, which may reduce their food security. The purpose of this study was to explore whether medical financial hardship is related to food security among cancer survivors.</p>Methods:<p>The study was based on cross-sectional data from the 2020 National Health Interview Survey. We used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security (i.e., high, marginal, low, or very low) among individuals ages ≥18 years who reported a cancer diagnosis from a health professional (<i>N</i> = 4,130).</p>Results:<p>The majority of the sample reported high household food security (88.5%), with 4.8% reporting marginal, 3.6% reporting low, and 3.1% reporting very low household food security. In the adjusted model, the odds of being in a lower food security category were higher for cancer survivors who had problems paying or were unable to pay their medical bills compared with those who did not [OR, 1.73; 95% confidence interval (CI), 1.06–2.82, <i>P =</i> 0.027], who were very worried about paying their medical bills compared with those who were not at all worried (OR, 2.88; 95% CI, 1.64–5.07; <i>P</i> < 0.001), and who delayed medical care due to cost compared with those who did not (OR, 2.56; 95% CI, 1.29–5.09; <i>P =</i> 0.007).</p>Conclusions:<p>Food insecurity is rare among cancer survivors. However, medical financial hardship is associated with an increased risk of lower household food security among cancer survivors.</p>Impact:<p>A minority of cancer survivors experience medical financial hardship and food insecurity; social needs screenings should be conducted.</p></div>

Journal ArticleDOI
05 Jan 2023
TL;DR: In this paper , a single-center retrospective review of patients diagnosed with bullous dermatophyte infection by skin biopsy was performed, and the authors summarized the histopathologic and clinical features of 25 biopsy-proven cases of bullous tinea.
Abstract: Bullous dermatophytosis is a rare blistering disorder resulting from fungal infection. Limited literature describes the clinical and microscopic features of this disease.To summarize the histopathologic and clinical features of 25 biopsy-proven cases of bullous tinea.The study was a single-center retrospective review of patients diagnosed with bullous dermatophyte infection by skin biopsy.Bullous tinea is rarely suspected clinically in biopsy-proven cases, often mimicking other spongiotic disorders that can vesiculate. In addition to classically taught histopathologic clues, several unique characteristics were observed in our population. The presence of dermal neutrophils as the nonpredominant cell type (85%; n = 17 of 20) can serve as an additional clue to diagnosis. Deep inflammation (25%; n = 5 of 20) does not exclude a superficial diagnosis. The classically taught sandwich sign (32%; n = 8 of 25) may be less relevant in the setting of bullous tinea. Hyphae were most commonly seen within the stratum corneum adjacent to this blister rather than within the blister itself, and special staining was required in a substantial number of cases (40%; n = 10 of 25) to reach the correct diagnosis.Bullous tinea is unusual but should be considered in the differential diagnosis of blistering skin disorders. Hematoxylin and eosin-stained slides frequently lack obvious fungal hyphae; for this reason, periodic acid-Schiff reaction or Gomori/Grocott methenamine silver stains should be routinely considered for biopsies showing intraepidermal and/or subepidermal blister formation and prominent neutrophil infiltration to prevent misdiagnosis.



Journal ArticleDOI
TL;DR: In this paper , the prevalence of, and associations between, family food insecurity and overweight/obesity among Native Hawaiian and Pacific Islander (NHPI) adolescents and explores socio-demographic factors which might have a moderation effect on the association.
Abstract: This study estimates the prevalence of, and associations between, family food insecurity and overweight/obesity among Native Hawaiian and Pacific Islander (NHPI) adolescents and explores socio-demographic factors which might have a moderation effect on the association.Cross-sectional study using 2014 NHPI-National Health Interview Survey data reported by a parent or guardian. Family-level food security was assessed by the US Department of Agriculture 10-item questionnaire. BMI for age and sex ≥ 85th and 95th percentiles defined overweight and obesity, respectively, according to US Centers for Disease Control and Prevention criteria.The USA, including all 50 states and the District of Columbia.383 NHPI adolescents aged 12-17 in the USA.A third (33·5 %) of NHPI adolescents aged 12-17 were overweight (19·1 %) or obese (14·4 %); 8·1 % had low food security; and 8·5 % had very low food security. Mean family food security score was 1·06, which corresponds to marginal food security. We found no association between family food insecurity and adolescent overweight/obesity or between any other covariates and overweight/obesity, except for family Supplemental Nutrition Assistance Program (SNAP) participation. Odds of being overweight/obese were 77 % lower for adolescents in families participating in SNAP (OR: 0·23, 95 % CI: 0·08, 0·64, P = 0·007). The association between SNAP participation and lower odds of overweight/obesity was particularly pronounced for adolescent girls in food-insecure families.The association between SNAP participation and lower odds of overweight/obesity suggests potential benefit of research to determine whether interventions to increase SNAP enrollment would improve NHPI adolescents' health outcomes.

Journal ArticleDOI
TL;DR: Asbestos-related pulmonary complications include asbestosis, pleural plaques, diffuse pleural thickening, benign asbestos-related pleural effusions and malignant pleural mesothelioma as discussed by the authors .
Abstract: Exposure to asbestos can cause both benign and malignant, pulmonary and pleural diseases. In the current era of low asbestos exposure, it is critical to be aware of complications from asbestos exposure; as they often arise after decades of exposure, asbestos-related pulmonary complications include asbestosis, pleural plaques, diffuse pleural thickening, benign asbestos-related pleural effusions and malignant pleural mesothelioma.Multiple recent studies are featured in this review, including a study evaluating imaging characteristics of asbestos with other fibrotic lung diseases, a study that quantified pleural plaques on computed tomography imaging and its impact on pulmonary function, a study that examined the risk of lung cancer with pleural plaques among two large cohorts and a review of nonasbestos causes of malignant mesothelioma.Asbestos-related pulmonary and pleural diseases continue to cause significant morbidity and mortality. This review summarizes the current advances in this field and highlights areas that need additional research.

Journal ArticleDOI
01 Mar 2023-JAAPA
TL;DR: Teigen et al. as discussed by the authors discussed the negative effects of prostate cancer diagnosis and treatment, the importance of screening these patients for depression, and the exploration of mindfulness as an adjunctive management option for this population.
Abstract: Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Ahead-of-PrintOnline Only Collections Addiction MedicineArt of MedicineCardiologyCMEInfectious DiseasePediatricsResearchSurgeryWomen's HealthView All CME CME Post-testsCME from AAPA BlogMultimedia PodcastsVideos Authors & Info Submit A Manuscript Info for Authors & ReviewersAbout the JournalEditorial BoardThe PA ProfessionRoadmap to Better WritingAdvertisingOpen AccessSubscription ServicesReprintsRights and PermissionsAuthor Permissions AAPA About AAPACME CalendarCME PosttestsAnnual ConferenceAAPA Salary ReportPA CompetenciesAAPA Publications All Articles Images Videos Podcasts Blogs Advanced Search March 2023 - Volume 36 - Issue 3 Previous Abstract Next Abstract AAPA Members can view Full text articles for FREE. Not a Member? Join today! Article as EPUB Export All Images to PowerPoint File Add to My Favorites Email to Colleague Colleague's E-mail is Invalid Your Name: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw in JAAPA. Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. Export to End Note Procite Reference Manager Save my selection Case ReportMindfulness for depression management in men with prostate cancerTeigen, Amber DMSc, PA-C Author Information Amber Teigen is associate program director and an assistant professor in the PA program at the University of Arkansas for Medical Sciences in Little Rock, Ark. The author has disclosed no potential conflicts of interest, financial or otherwise. JAAPA 36(3):p 28-31, March 2023. | DOI: 10.1097/01.JAA.0000911220.25098.91 Buy Metrics Abstract Increasing incidence and survival rates of prostate cancer are leaving more men to suffer the sequelae of their diagnosis and treatment, like depression. Depression and other negative psychosocial factors significantly affect this population but often go undiagnosed and/or ineffectively managed. This case report focuses on the negative effects of prostate cancer diagnosis and treatment, the importance of screening these patients for depression, and the exploration of mindfulness as an adjunctive management option for this population. Copyright © 2023 American Academy of Physician Associates Full Text Access for Subscribers: Individual Subscribers Log in for access AAPA Members – click here Institutional Users Access through Ovid® Not a Subscriber? Buy Subscribe Request Permissions You can read the full text of this article if you: Select an option Log In Buy Article Subscribe Content & Permissions Access through Ovid Log In Access through Ovid Source Mindfulness for depression management in men with prostate cancer JAAPA36(3):28-31, March 2023. Full-Size Email + Favorites Export View in Gallery Email to Colleague Colleague's E-mail is Invalid Your Name: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw in JAAPA. Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. Related Videos Data is temporarily unavailable. Please try again soon. Related Links Articles in PubMed by Amber Teigen, DMSc, PA-C Articles in Google Scholar by Amber Teigen, DMSc, PA-C Other articles in this journal by Amber Teigen, DMSc, PA-C Article as EPUB Export All Images to PowerPoint File Add to My Favorites Email to Colleague Colleague's E-mail is Invalid Your Name: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw in JAAPA. Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. Export to End Note Procite Reference Manager Save my selection Article Level Metrics Article Keywords Keywords prostate cancer , depression , screening , mindfulness , quality of life , mindfulness-based interventions Search for Similar Articles You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search. prostate cancer\r, depression\r, screening\r, mindfulness\r, quality of life\r, mindfulness-based interventions Related Collections Mental health Readers Of this Article Also Read A patient with untreated preeclampsia and peripartum cardiomyopathy A preventable, life-altering case of fluoroquinolone-associated tendonitis Lung cancer screening in primary care A curious case of a blue finger Are beta-blockers safe and effective after myocardial infarction in patients with COPD? Back to Top Never Miss an Issue Get new journal Tables of Contents sent right to your email inbox Get New Issue Alerts Browse Journal Content Most Popular For Authors About the Journal Past Issues Current Issue Register on the website Subscribe Get eTOC Alerts For Journal Authors Submit an article How to publish with us Customer Service Live Chat Chat Offline Activate your journal subscription Activate Journal Subscription Browse the help center Help Contact us at: EMAIL: [email protected] TEL: (USA): TEL: (Int’l): 800-638-3030 (within USA) 301-223-2300 (international) Cookie Settings Privacy Policy (Updated December 15, 2022) Legal Disclaimer Terms of Use Open Access Policy Feedback LWW Journals Copyright © 2023 American Academy of PAs

Journal ArticleDOI
01 Mar 2023
TL;DR: In this article , the authors explored the effect of antecedent serum lipid levels on the risk of COVID-19 infection and found that the highest trajectory for antecedient serum HDL-C level was associated with a lower risk for COVID19 infection (RR 0.63, 95% CI 0.46-0.86).
Abstract: ASCVD/CVD Risk Factors Host cell-membrane cholesterol, an important player in viral infections, is in constant interaction with serum lipids, such as high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Recent meta-analyses have shown an association between low serum lipid levels at hospital admission and COVID-19 severity. However, the effect of antecedent serum lipid levels on the risk of COVID-19 infection has not been explored previously. Our retrospective cohort from the Arkansas Clinical Data Repository included all adults with lipid levels available within the 2 years antecedent to COVID-19 testing. We assessed the association of trajectories of lipid levels antecedent to COVID-19 testing, identified using group-based-trajectory-modeling with the risk of COVID-19 infection using multivariable log-binomial regression. We used mixed-effects linear regression to assess the trends in serum lipid levels followed up to the time of, and 2-months after COVID-19 testing. Among the 11001 individuals, 1340 (12.2%) tested positive for COVID-19. The median age was 59 years (IQR 46-70) and 40.8% were males. Log-binomial regression showed that the highest trajectory for antecedent serum HDL-C level was associated with a lower risk for COVID-19 infection (RR 0.63, 95% CI 0.46-0.86). Antecedent serum LDL-C, total cholesterol (TC), and triglycerides (TG) levels showed no independent association with COVID-19 infection risk. But the COVID-19 infection risk was the highest in the subgroup with lower HDL-C (Trajectory 1) and higher LDL-C or higher TG (Trajectory 3). In COVID-19 patients, at the time of testing, serum HDL-C (-7.7, 95% CI -9.8 to -5.5 mg/dL), LDL-C (-6.29, 95% CI -12.2 to -0.37 mg/dL) and TC (-11.71, 95%CI -18.9 to -4.5 mg/dL), but not TG levels, were lower. These returned to pre-infection values by 2-months following COVID-19 testing. Higher antecedent serum HDL-C, but not LDL-C, TC, and TG levels, were associated with a lower COVID-19 infection risk. Serum HDL-C, LDL-C, and TC levels declined transiently at the time of diagnosis, returning to pre-infection levels during follow-up. The results of our study could provide the impetus for clinical trials aimed at increasing HDL-C, such as CETP inhibitors, in the prevention and amelioration of COVID-19 infection or infections in general.

Journal ArticleDOI
TL;DR: In this paper , a needs assessment of health literacy education using simulation, to guide faculty development for simulation educators was performed using Kern's curricular development process, problem identification, general and targeted needs assessments.
Abstract: Understanding health literacy is crucial to improve health and reduce disparities. Simulation is an effective active learning strategy to teach health literacy. Our aim was to perform a needs assessment of health literacy education using simulation, to guide faculty development for simulation educators. Utilizing Kern’s curricular development process, problem identification, general and targeted needs assessments were performed. PubMed, CINAHL and PsycINFO searches were conducted using terms for health literacy and ‘prioritized health literacy competencies’ (PHLCs). Abstracts and full texts were screened. Simulation events that could feasibly incorporate health literacy were included. Data were collected regarding learners, type of event and incorporation of PHLCs. A targeted needs assessment used electronic survey to identify knowledge, attitudes and beliefs of local simulation educators regarding health literacy. Health literacy components of local simulation events (2018–2019) were assessed using a tool developed by the investigative team. Literature search identified 614 published articles, and 67 were included in analysis. ‘Avoidance of jargon’ (14/67) and ‘patient-centred approaches’ (11/67) were the most commonly cited PHLCs. No articles mentioned ‘delivery of information in 1–3 need-to-know elements’. Of the 57/881 local simulation events that could feasibly incorporate health literacy, 17/57 did so. ‘Jargon’ and ‘patient-centred’ care were the PHLCs most often present in learning objectives. Survey response rate was 77%. Only 18% (3/17) of local simulation educators demonstrated ‘comprehensive understanding’ of health literacy. Educators reported understanding ‘using universal precautions in written and oral communication’ (mean Likert 3.3) and ‘need-to-know/need-to-do concepts’ (3.4) least well. The majority felt including health literacy was important in simulation and believed they did this. There is a critical need to formalize and standardize language used when creating and studying simulations involving health literacy. An interprofessional faculty education program may assist faculty understanding of PHLCs when designing focused simulations for future healthcare providers.


Journal ArticleDOI
TL;DR: In this article , the authors evaluated the factors that impacted time from GDI surgery to PK in eyes with previously clear corneas (i.e., GDI-first sequence), and that specifically underwent a trabeculectomy prior to GDI for intraocular pressure control.
Abstract: Precis: We evaluated the factors that impacted time from GDI surgery to PK in eyes with previously clear corneas (i.e., GDI-first sequence), and that specifically underwent a trabeculectomy prior to GDI surgery for intraocular pressure control. Purpose: To describe through an event-triggered data collection method the clinical course and the long-term outcomes of 2 procedures that are commonly performed sequentially in complex clinical situations: glaucoma drainage implant (GDI) surgery and penetrating keratoplasty (PK). The study investigates the clinical factors associated with progression to PK and determines the GDI success rate and graft survival. Methods: A single, tertiary-care center retrospective interventional cases series including patients with a sequential history of trabeculectomy, GDI surgery, and PK from 1999 to 2009. Outcome measures included intraocular pressure (IOP), visual acuity, graft failure, GDI failure, and time from GDI to PK. Results: 56% of eyes had primary open-angle glaucoma. The time from the last trabeculectomy to GDI was 66.5 +/- 66.7 months. 84% of eyes received a Baerveldt GDI. Time from GDI to PK was 36.4 +/- 28.4 months. IOP at the time of PK was between 5−21 mmHg in 90% of eyes. At the last follow-up, 48% of grafts were clear. At 5 years post-PK, 33% of corneal grafts remained clear, while 81% of tubes remained functional. Conclusions: Nearly half of the corneal grafts are clear at the last long-term follow-up. Graft failure occurs at a higher rate than tube failure suggesting that IOP control is only one and possibly not the most important factor in graft survival in eyes with prior glaucoma surgery.



Journal ArticleDOI
01 Jan 2023
TL;DR: In this article , the authors described small bowel obstruction secondary to a Meckel's Diverticulum in a 5-year-old male patient with a chief complain of abdominal pain and vomiting.
Abstract: This case describes small bowel obstruction secondary to a Meckel's Diverticulum in a 5-year-old male patient with a chief complain of abdominal pain and vomiting. We review the pathophysiology, diagnosis, and management of Meckel's Diverticulum. This case report highlights the importance of considering a broad differential diagnosis during a clinical workup.

Journal ArticleDOI
TL;DR: In this article , the authors present a case of an eccrine porocarcinoma in the vulva of a 70-year-old woman that, in addition, showed sarcomatoid transformation.
Abstract: Eccrine porocarcinoma is a rare cutaneous neoplasm, and rarer still in the anogenital region. In the vulva, the most common carcinoma by far is squamous cell carcinoma; however, eccrine porocarcinoma can arise at this site. As the distinction between porocarcinoma and squamous cell carcinoma has important prognostic implications at other cutaneous sites, it stands to reason that it may have these same implications in the vulva. We present a case of an eccrine porocarcinoma in the vulva of a 70-year-old woman that, in addition, showed sarcomatoid transformation. This tumor harbored human papillomavirus-18 DNA and mRNA, raising the question of the role of the oncogenic virus in sweat gland neoplasms of the vulva.

Journal ArticleDOI
TL;DR: In this paper , the authors used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security among individuals with cancer diagnosis from a health professional.
Abstract: Abstract Background: Some cancer survivors experience medical financial hardship, which may reduce their food security. The purpose of this study was to explore whether medical financial hardship is related to food security among cancer survivors. Methods: The study was based on cross-sectional data from the 2020 National Health Interview Survey. We used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security (i.e., high, marginal, low, or very low) among individuals ages ≥18 years who reported a cancer diagnosis from a health professional (N = 4,130). Results: The majority of the sample reported high household food security (88.5%), with 4.8% reporting marginal, 3.6% reporting low, and 3.1% reporting very low household food security. In the adjusted model, the odds of being in a lower food security category were higher for cancer survivors who had problems paying or were unable to pay their medical bills compared with those who did not [OR, 1.73; 95% confidence interval (CI), 1.06–2.82, P = 0.027], who were very worried about paying their medical bills compared with those who were not at all worried (OR, 2.88; 95% CI, 1.64–5.07; P &lt; 0.001), and who delayed medical care due to cost compared with those who did not (OR, 2.56; 95% CI, 1.29–5.09; P = 0.007). Conclusions: Food insecurity is rare among cancer survivors. However, medical financial hardship is associated with an increased risk of lower household food security among cancer survivors. Impact: A minority of cancer survivors experience medical financial hardship and food insecurity; social needs screenings should be conducted.

Journal ArticleDOI
TL;DR: In this article , a term infant who developed necrotizing enterocolitis after treatment for congenital syphilis was found to have been the first to develop the disease after antibiotic exposure.
Abstract: Necrotizing enterocolitis is a disease process of intestinal disruption which has been associated with gastrointestinal microbial alterations after antibiotic exposure. Treatment guidelines and antibiotic exposure for congenital syphilis have historically been based on limited evidence. This case presents a term infant who developed necrotizing enterocolitis after treatment for congenital syphilis.

Book ChapterDOI
01 Jan 2023




Journal ArticleDOI
TL;DR: In this paper , the authors used LC-MS-MS to quantify brain concentrations of BUP, NorBUP, and their glucuronide conjugates, and found that females are more susceptible to NorBuprenorphine-induced NOWS, and that treatment strategies that reduce prenatal BUP exposure may be more effective for females than males.
Abstract: Buprenorphine (BUP) is the preferred treatment for opioid use disorder during pregnancy but can cause neonatal opioid withdrawal syndrome (NOWS). Norbuprenorphine (NorBUP), an active metabolite of BUP, is implicated in BUP-associated NOWS. We hypothesized that BUP, a low-efficacy agonist of mu opioid receptors, will not antagonize NorBUP, a high-efficacy agonist of mu opioid receptors, in producing NOWS. To test this hypothesis, we treated pregnant Long-Evans rats with BUP (0, 0.01, 0.1 or 1mg/kg/day) ± NorBUP (1mg/kg/day) from gestation day 9 until pup delivery, and tested pups for opioid dependence using our established NOWS model. We used LC-MS-MS to quantify brain concentrations of BUP, NorBUP, and their glucuronide conjugates. BUP had little effect on NorBUP-induced NOWS, with the exception of 1mg/kg/day BUP significantly increasing NorBUP-induced NOWS by 58% in females. BUP and NorBUP brain concentrations predicted NOWS in multiple linear regression models. Interestingly, NorBUP contributed more to NOWS in females (βNorBUP = 51.34, p = 0.0001) than in males (βNorBUP = 19.21, P = 0.093), while BUP was similar for females (βBUP = 10.62, P = 0.0017) and males (βBUP = 11.38, P = 0.009). We are the first to report that NorBUP induces NOWS in the presence of BUP and it is more influential in females than males in the contribution of NorBUP to BUP-associated NOWS. These findings suggest that females are more susceptible to NorBUP-induced NOWS, and that treatment strategies that reduce prenatal NorBUP exposure may be more effective for females than males.

Journal ArticleDOI
TL;DR: In this paper , the Disclosure of Potential Conflicts of Interest form is provided with the online version of the article (https://links.lww.com/JBJS/H482).
Abstract: 1University of Arkansas for Medical Sciences, Little Rock, Arkansas Disclosure: The Disclosure of Potential Conflicts of Interest form is provided with the online version of the article (https://links.lww.com/JBJS/H482).

Book ChapterDOI
01 Jan 2023
TL;DR: In this paper , the authors address driving and community mobility concerns, and related issues that the occupational therapy practitioner can address in primary care, outlining the basic role of the primary care physician, as well as the evaluation techniques and intervention strategies employed by the occupational therapist practitioner.
Abstract: This chapter will address driving and community mobility concerns, and related issues that the occupational therapy practitioner can address in primary care. The chapter will outline the basic role of the primary care physician, as well as the evaluation techniques and intervention strategies employed by the occupational therapy practitioner.

Journal ArticleDOI
TL;DR: In this paper , the authors reviewed the literature with respect to the value of EUS-B, rapid on-site evaluation, and final diagnostic yield for structures below the diaphragm.