SAGE open medical case reports 

About: SAGE open medical case reports is an academic journal published by SAGE Publishing. The journal publishes majorly in the area(s): Medicine & Internal medicine. It has an ISSN identifier of 2050-313X. It is also open access. Over the lifetime, 1549 publications have been published receiving 3570 citations. The journal is also known as: Open medical case reports & Medical case reports.

Unexpected improvement in core autism spectrum disorder symptoms after long-term treatment with probiotics.

Abstract: Objectives:Autism spectrum disorder is a neurodevelopmental condition that typically displays socio-communicative impairment as well as restricted stereotyped interests and activities, in which gastrointestinal disturbances are commonly reported. We report the case of a boy with Autism Spectrum Disorder (ASD) diagnosis, severe cognitive disability and celiac disease in which an unexpected improvement of autistic core symptoms was observed after four months of probiotic treatment.Method:The case study refers to a 12 years old boy with ASD and severe cognitive disability attending the Villa Santa Maria Institute in resident care since 2009. Diagnosis of ASDs according to DSM-V criteria was confirmed by ADOS-2 assessment (Autism Diagnostic Observation Schedule).The medication used was VSL#3, a multi-strain mixture of ten probiotics. The treatment lasted 4 weeks followed by a four month follow-up.The rehabilitation program and the diet was maintained stable in the treatment period and in the follow up. ADOS-2...

Guillain-Barré syndrome with unilateral peripheral facial and bulbar palsy in a child: A case report.

Abstract: Guillain–Barre syndrome is characterized by progressive motor weakness, sensory changes, dysautonomia, and areflexia. Cranial nerve palsies are frequent in Guillain–Barre syndrome. Among cranial ne...

The successful use of therapeutic plasma exchange for severe COVID-19 acute respiratory distress syndrome with multiple organ failure

Abstract: The COVID-19 pandemic has brought about an urgent need for effective treatment, while conserving vital resources such as intensive care unit beds and ventilators Antivirals, convalescent plasma, and biologics have been used with mixed results The profound "cytokine storm" induced endotheliopathy and microthrombotic disease in patients with COVID-19 may lead to acute respiratory distress syndrome, sepsis, and multi-organ failure We present a case of SARS-COV2 pneumonia with septic shock and multi-organ failure that demonstrated significant clinical improvement after therapeutic plasma exchange A 65-year-old female with multiple comorbidities presented with progressive dyspnea and dry cough She was found to be COVID-19 positive with pneumonia, and developed progressive hypoxemia and shock requiring vasopressors, cardioversion, and non-invasive positive pressure ventilation Given her worsening sepsis with multi-organ failure, she underwent therapeutic plasma exchange with rapid clinical improvement Her case supports the theory that plasma exchange may help abate the "cytokine storm" induced endotheliopathy and microthrombosis associated with COVID-19 Further studies are needed to identify markers of this pathway and the potential role of plasma exchange in these critically ill patients

Atezolizumab-related encephalitis in the intensive care unit: Case report and review of the literature.

Abstract: Atezolizumab is a monoclonal antibody that targets programmed death ligand-1. Treatments with this drug may cause immune-related adverse events by creating an exaggerated inflammatory response. The...

Usefulness of preoperative echography for detection of lymphatic vessels for lymphaticovenous anastomosis.

Abstract: Case 1: A 63-year-old woman with secondary lower limb lymphedema. As it was difficult to detect the lymphatic vessels in the right thigh in indocyanine green lymphography because of thick fat, we tried echography and observed circular structures beneath the superficial fascia. Intraoperatively, we found a dilated lymphatic vessel just as observed on echography. Case 2: A 45-year-old woman with primary lower limb lymphedema. As she was allergic to iodinated contrast medium, we could not use indocyanine green lymphography preoperatively. In echography, we found vascular architectures and found the dilated lymphatic vessels intraoperatively just as observed on echography. In conclusion, application of echography in detecting the lymphatic vessels was useful as a preoperative examination of lymphaticovenous anastomosis.