Academic Journal of Second Military Medical University 

About: Academic Journal of Second Military Medical University is an academic journal. The journal publishes majorly in the area(s): Cancer & Gene. It has an ISSN identifier of 0258-879X. Over the lifetime, 2183 publications have been published receiving 1947 citations.

Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in dogs

Abstract: Objective:To investigate the feasibility and efficiency of autologous intracoronary mononuclear bone marrow cell transplantation for treatment of dog myocardial infarction. Methods: Ten male dogs underwent permanent left anterior descending coronary arteries occlusion by balloon to establish myocardial infarction(MI) model. About 1 week after extensive MI, dogs were divided into transplantation group (n=5) and control group(n=5). Echocardiography study was performed before and 60 d after implantation to assess left ventricular remodeling and function. Dogs were sacrificed and specimens were harvested 60 d post-implantation;histologic sections were examined under a fluorescent microscopy. Results: The left ventricular end-diastolic volume(LVEDV) and left ventricular end-systolic volume(LVESV) decreased in transplantation group, while EF and FS increased significantly(P0.05) and SV insignificantly. The LVEDV and LVESV in control group increased obviously, while FS decreased significantly(P0.05) and SV and EF insignificantly. The LVESV in transplantation group was significantly lower than that of control group(P0.05) while LVEDV insignificantly; EF and FS in transplantation group was significantly higher than that of control group(P0.05) while SV insignificantly. The LV diastolic and systolic enternal diameter and the length of infarction area decreased after transplantation and the thickness of infarction area increased(P0.05), while the thickness in control group decreased. In transplantation group the cardiac anterior wall was positively stained under fluorescent microscope with green fluorescent myofilaments and myotubes, while the fluorescence in inferior wall of transplantation group and anterior wall of control group was weaker and with no fluorescent myofilaments and myotubes.Conclusion: Autologous mononuclear bone marrow cells can be implanted and survive in the infarcted myocardium, which can attenuate infarct thinning, myocardial remodeling and dysfunction, and may provide a new approach for myocardial repair.

Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: A COPCORD study

Abstract: Objective: To carry out a cross-sectional survey on prevalence of musculoskeletal symptoms, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and gout Methods: Four communities comprising 7 603 inhabitants over 15 years of age in an urban population were randomly selected from 13 communities in Shanghai Interviews were conducted from September 1997 to March 1998 by trained physicians using the COPCORD Core Questionnaire Physical and radiographic examinations and serologic tests were carried out when required to classify categories of rheumatic diseases The diagnosis of RA, systemic lupus erythematosus (SLE), and gout were based on American Rheumatism Association criteria The diagnosis of AS strictly followed the modified New York criteria of 1984 Crude prevalence rates were standardized according to a standard Chinese population for age and sex structure Results: A total of 6 584 adults (3 394 women, 3 190 men) were interviewed, and response rate was 86 6% The age and sex standardized prevalence rate of rheumatic symptoms at any site amounted to 13 3% (95% CI 12 5-14 1%) Symptoms occurred more frequently in the following sites; knee 7 0% (95% CI 64-76%), lower back 56% (95% CI 50-62%), shoulder 47% (95% CI 42-52%), and neck 24% (95% CI 20-2 8%) Women complained of rheumatic symptoms more frequently than men The standardized rates of RA, AS, gout, symptomatic knee osteoarthritis, and soft tissue rheumatism were 0 28% (95% CI 0 15-0 41%), 0 11% (95% CI 0 03-0 19%), 022% (95% C10 11-0 33%), 41% (95% CI 3 6-4 6%), and 34% (95% CI 30-38%), respectively Two cases of SLE, one case of dermatomyositis, and one case of systemic sclerosis were found Conclusion: Compared with European and Western countries, the prevalence of RA, AS, and gout are low in Shanghai, China, although the prevalence of rheumatic symptoms are high

Effects of titanium dioxide nanoparticles on development and maturation of rat preantral follicle in vitro.

Abstract: Objective:To study the influence of titanium dioxide nanoparticle(TiO2) on follicle development and oocyte maturation of rats using in vitro rat preantral follicle culture system,so as to know whether TiO2 can cause female reproductive toxicity and provide evidences for evaluating its safetyMethods:Rat ovaries were mechanically dissected to obtain preantral follicles and the individual preantral follicle was cultured in 96-well platesThe study was divided into 5 groups:three 25 nm TiO2 groups(125 μg/ml,25 μg/ml and 50 μg/ml),one negative control group(treated with culture medium),and one micron TiO2 control groupTen days after culture,the ovulation was induced and the follicle development and oocyte maturation were observedResults:The survival rate of follicles,formation rate of antral follicles and release rate of cumulus-oocyte cell complexes(COCs) all decreased with the increase of 25 nm TiO2(P005)Compared with the negative control group,micron TiO2 group had no obvious changes in the follicle development and oocyte maturationCompared with the two control groups,25 nm TiO2 caused obvious morphological changes of follicles and obvious decrease in follicle survival and formation rate of antral follicles50 μg/ml 25 nm TiO2 reduced the number of mature oocytesConclusion:25 nm TiO2 at 25 μg/ml or above can inhibit rat follicle development and oocyte maturation in vitro,while the micron TiO2 at the same dose has no obvious influence on follicle development and oocyte maturation,suggesting different toxic properties between nmTiO2 and micron TiO2Titanium dioxide nanoparticle may have female reproductive toxicity and should be given more attention