Showing papers in "Annals of Surgery in 1972"

Anti-angiogenesis: new concept for therapy of solid tumors.

Abstract: SOLID tumor growth in animals and in man is accompanied by neovascularization. New capillary growth is elicited by a diffusible factor generated by malignant tumor cells. In the absence of neovascularization most tumors might become dormant at a tiny diameter, perhaps 2-3 mm.9' 10 Although evidence for these statements is still indirect and fragmentary, it seems appropriate to speculate that the inhibition of angiogenesis, i.e., anti-angiogenesis, may provide a form of cancer therapy worthy of serious exploration. The evidence for such a contention, based on recent findings in our own laboratory and others, will be examined in this report.

Interposition mesocaval shunt for treatment of portal hypertension.

Abstract: Interposition Mesocaval Shunt for Treatment of Portal Hypertension THEODORE DRAPANAS; Annals of Surgery