Biomedical and Pharmacology Journal 

About: Biomedical and Pharmacology Journal is an academic journal published by Oriental Scientific Publishing Company. The journal publishes majorly in the area(s): Medicine & Internal medicine. It has an ISSN identifier of 0974-6242. It is also open access. Over the lifetime, 2464 publications have been published receiving 8409 citations.

Brain Tumor Classification Using Convolutional Neural Networks

Abstract: The brain tumors, are the most common and aggressive disease, leading to a very short life expectancy in their highest grade. Thus, treatment planning is a key stage to improve the quality of life of patients. Generally, various image techniques such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and ultrasound image are used to evaluate the tumor in a brain, lung, liver, breast, prostate…etc. Especially, in this work MRI images are used to diagnose tumor in the brain. However the huge amount of data generated by MRI scan thwarts manual classification of tumor vs non-tumor in a particular time. But it having some limitation (i.e) accurate quantitative measurements is provided for limited number of images. Hence trusted and automatic classification scheme are essential to prevent the death rate of human. The automatic brain tumor classification is very challenging task in large spatial and structural variability of surrounding region of brain tumor. In this work, automatic brain tumor detection is proposed by using Convolutional Neural Networks (CNN) classification. The deeper architecture design is performed by using small kernels. The weight of the neuron is given as small. Experimental results show that the CNN archives rate of 97.5% accuracy with low complexity and compared with the all other state of arts methods.

Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin

Abstract: Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. The current study presents a pharmacological review on the drug including its mechanism of action, resistance mechanism, and toxicity as well as its clinical applications. The mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells. However, the drug exhibits certain level of resistance including increased repair of the damaged DNA, reduction in the accumulation of the drug intracellular and cytosolic inactivation of cisplatin. The drug is also characterized by various toxic side effects including nausea, nephrotoxicity, Cardiotoxicity, hepatotoxicity and neurotoxicity. Due various side effects as well as drug resistance, other anti-cancer drugs that contain platinum such as carboplatin and oxaliplatin among others have been used in combination with cisplatin in chemotherapeutic treatment of cancer. Strong evidence from research has demonstrated higher efficacy of combination of chemotherapies of cisplatin together with other drugs in overcoming drug resistance and in reducing toxic effects as well. Future studies that explore combinational techniques that target various mechanisms such as reduction in the uptake of cisplatin as well as inflammation could enhance efficacy of cisplatin.

Recurrent Aphthous Stomatitis: A Review

Abstract: Recurrent Aphthous Stomatitis (RAS) is a disorder characterized by recurring ulcers in the oral mucosa in patients with no other signs of disease. This condition is also called as Sutton’s disease, especially in the case of major, multiple or recurring ulcers. RAS appears to represent several pathological states with similar clinical manifestations, including immunologic disorders, hematologic deficiencies and allergic or psychological abnormalities. This article reviews the current data on the etiopathogenesis, diagnosis and management of RAS.

A Review Article on Hyperlipidemia: Types, Treatments and New Drug Targets

Abstract: Hyperlipidemia is a medical condition characterized by an increase in one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids and or plasma lipoproteins including very low-density lipoprotein and low-density lipoprotein along with reduced high-density lipoprotein levels. This elevation of plasma lipids is among the leading risk factors associated with cardiovascular diseases. In the meantime, statins and fibrates remain the major anti-hyperlipidemic agents for the treatment of elevated plasma cholesterol and triglycerides respectively, with the price of severe side effects on the muscles and the liver. The present review focuses mainly on the types of hyperlipidemias, lipid metabolism, treatments and new drug targets for the treatment of elevated lipid profile. Many agents such as lanosterol synthase inhibitors, squalene epoxidase inhibitors, diacyl glycerol acyl transferase inhibitors, ATP citrate lyase inhibitors have shown a promising potential in the treatment of hyperlipidemia in clinical trials.