Bollettino dell'Istituto sieroterapico milanese 

About: Bollettino dell'Istituto sieroterapico milanese is an academic journal. The journal publishes majorly in the area(s): Antigen & Antibody. It has an ISSN identifier of 0021-2547. Over the lifetime, 638 publications have been published receiving 1783 citations.

Flavonoids and hepatic cyclic monophosphates in liver injury

Abstract: Among the large spectrum of pharmacological activities of flavonoids, play an important role the recently investigated properties involving the arachidonic acid metabolism. In order to clarify the mechanisms of "cytoprotection" of the 3-palmitoyl-(+)-catechin (Palm-cat), a new flavonoid compound (C31 H44 O7) we have studied in experimental hepatitis of the rat, induced by Galactosamine (Ga1N) and E. coli 055:B 5 endotoxin (LPS), hepatic cAMP and cGMP, transaminases, bilirubin and endotoxemia. The Palm-cat significantly increases cyclic-GMP levels in the liver, whereas reduces or slightly modifies the cAMP. Transaminases and bilirubin values increase both in controls and flavonoid treated rats. The flavonoid significantly decreases the frequency of endotoxemia. These effects suggest that RES and hepatocytes functions, immune and inflammatory response can be affected in liver disease by flavonoids via cyclic nucleotides regulation.

Epidemiology of viral hepatitis in Italy.

Abstract: Recent data from different research groups on the epidemiology of viral hepatitis in Italy were reviewed. Type A viral hepatitis shows the widest spreading in Southern Italy, where high prevalences of anti-HAV have been recorded among children. Type B viral hepatitis is endemic in Italy, as born out by high prevalences of HBsAg healthy carriers, of anti-HBs and/or anti-HBc positive subjects and of acute and chronic type B hepatitis. Non A/non V viral hepatitis represents about 50% of posttransfusion hepatitis and about 20% of adult sporadic cases.