Showing papers in "Contraception in 1970"

TL;DR: The results show that continuous release of cyproterone acetate at doses too low to inhibit testicular and androgenic function altered the internal milieu of the epididymis resulting in loss of motility and viability of sperm.

TL;DR: The antifertility effect of intrauterine copper in the rat seems to be due to a local change in the intrauterne environment such that the blastocyst does not implant.

TL;DR: This cross-sectional, random sampling technique, which is far more practical than daily serial sampling throughout a whole month, provided much useful information about the cycles of women using vaginal or intrauterine contraceptives, or while receiving steroidal contraceptive agents by mouth or parenterally.

TL;DR: The Beard-Prenant hypothesis of the antiovulatory action of the corpus luteum induced the physiologist Ludwig Haberlandt in 1919 to start experiments in animals, which led to temporary or permanent sterilization in the human.

TL;DR: It is probable that the cells produced by the foreign body and the associated biochemical changes in the uterus are the underlying cause of the antifertility effect.

TL;DR: A three-dimensional reconstitution of glandular volumes and of the endometrium that contains them led to the following conclusion glandularVolume increased by 100 % and stromal volume increased by 50 % in the patients treated with ethinyl-estradiol as compared to the patients treating with mestranol.

TL;DR: Contraceptive effectiveness and acceptability of subcutaneous silastic capsules containing Megestrol Acetate were evaluated and data suggest that in most patients in both groups conception is prevented without inhibition of ovulation.

TL;DR: In this paper, the authors found that immunoglobulins and secretory piece (SP) are present in appreciable amounts in the endometrium, fallopian tubes and cervix, whereas Lactoferrin is completely absent from the decidua and the fallopian tube tissue unless polymorphonuclear leukocytes are present.

TL;DR: Subtoxic doses of alpha-chlorohydrin were fed to 5 adult male rhesus monkeys in an attempt to produce functional sterility, and the only significant changes were increased zinc-65 uptake and oxygen consumption by vasal spermatozoa.

TL;DR: Calcium and zinc chloride were effective in impairing the motility and viability of human spermatozoa at high molar concentrations and the possibility of using these salts in fertility regulation is suggested.

TL;DR: Factors such as the route of excretion, rate ofexcretion, degree and pattern of conjugation suggest that ethynylestradiol is metabolized in the same manner as natural estrogens.

TL;DR: Of agents effective in preventing implantation or interfering with embryonic development in the rabbit, teratogenicity has been noted with clomid, U11, 100A, U 11, 555A, parahydroxypropiophenone, vinblastine, colcemide, BW 57-323H, and 6-azauridine.

TL;DR: There is a marked interspecies difference in the relation of Chlormadinone acetate and norethindrone, and the importance of establishing pharmacologically analogous doses (PAD) before initiating toxicity studies in experimental animals is emphasized.

TL;DR: The data suggest that (a) the IUD sometimes interferes with the course of the pregnancy, (b) removal of the tailed IUD improves the chances of a live birth, and (c) manipulation in pregnancies with a tailless IUD in situ increases the chance of abortion.

TL;DR: C.A. or progesterone -7-H 3 was administered intravenously to patients 8 hours before hysterectomy, and at this time tissue samples were taken for counting, and the highest tissue concentration of chlormadinone acetate in the tissues examined was found to be in the subcutaneous abdominal fat.

TL;DR: The 2-phenyl-3-p-(β-pyrrolidinoethoxy)-phenyl (2:1,b) naphthofuran compound causes 100% prevention of conception in rats, mice, and rhesus monkeys at a single oral dose and has a favorable therapeutic index.

TL;DR: In this article, the authors obtained endometrial biopses from women who were using sequential or combination type oral contraceptives low dose continuous progestogen pills once-a-month pills or depot progestogens (150 mg 16-alpha 17-alpha dihiaroxyprogesterone acetonide plus 10 mg estrodiol enanthate monthly 150 mg medroxyprogestersterone (MP) every three months or 150 mg MP plus 150 mg estradiol phosphate every 3 months) for periods up to 10 years.

TL;DR: A combination of quinestrol, a long-acting estrogen, and quingestanol acetate, a progestin, given by mouth once every four weeks was found to be an effective contraceptive in 303 healthy, fertile women for 2,493 cycles as mentioned in this paper.

TL;DR: The results of the use of quingestanol acetate, a progestagen, taken routinely by fertile, married women in a single dose less than 24 hours after coitus are reported.

TL;DR: The data do not support the hypothesis that the release of intracellular material from FB-damaged cells adversely affects the survival of pre-implantation embryos and lead to the conclusion that leucocytic factors do not appear to be responsible for any alterations in the biological properties of the uterine fluid of FB-treated primates.

TL;DR: Recommendations for physicians to employ prior to the initiation of hormonal contraceptives and a list of contraindications and special observations for patients receiving this type of contraception are outlined.

TL;DR: The implant method of contraception is well accepted by patients and has resulted in no serious local or systemic complications, and the era of implant contraception has begun.

TL;DR: A parenteral estrogen-progestogen preparation administered intramuscularly at monthly intervals has been studied in 385 patients during 4512 cycles and no pregnancies were established during the use of the medication.

TL;DR: In diestrus, estrus, and day 5 post-coitus rats an IUFB induces significant increases in the intrauterine concentrations of lysosomal enzymes and WBC's, and that these changes do not parallel the enzyme concentrations within the uterine tissue itself.

TL;DR: It is questionable whether the trophoblast may assume adequate endocrine function even before the 7th week to compensate for the missing ovary, and the pituitary gland is not essential for maintenance of human pregnancy.

TL;DR: Ion-exchange and silvered Florisil column chromatography appear to give better recovery of the ethynyl steroid glucuronides than direct urine hydrolyses methods and the excretory pattern of mestranol appears to differ significantly from that of the parent compound and shows considerable individual variation.

TL;DR: One in four women found all contraceptives frightening, so that emotional barriers to their use was common, and the present technique may also be useful in studying social factors which may influence attitudes to contraceptives.

TL;DR: Net cumulative rates of pregnancy, expulsions, and removals for medical and personal reasons are shown for the four new models of intrauterine devices, and for purposes of comparison, for loop D and the steel ring as well.

TL;DR: Data suggest that the hormonal environment at certain periods of premenopausal life may affect the future incidence of breast carcinoma, hence the data from estrogen use by menopausal women may not be directly relatable to the problem of oral contraceptive usage.

TL;DR: Twenty women were studied to determine the effect of low dosage estrogens and progestogens upon quantitative serum proteins and significant decrease in albumin and increases in alpha-2- and beta globulins occurred with mestranol 0.1 mg.