Journal•ISSN: 0954-6928
Coronary Artery Disease
Lippincott Williams & Wilkins
About: Coronary Artery Disease is an academic journal published by Lippincott Williams & Wilkins. The journal publishes majorly in the area(s): Myocardial infarction & Coronary artery disease. It has an ISSN identifier of 0954-6928. Over the lifetime, 3224 publications have been published receiving 50620 citations. The journal is also known as: Coron. Artery Dis..
Topics: Myocardial infarction, Coronary artery disease, Percutaneous coronary intervention, Medicine, Conventional PCI
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TL;DR: The normal structure and function of the right ventricle is reviewed and the impact of PAH and its treatments on right ventricular function is summarized.
Abstract: Pulmonary arterial hypertension (PAH) is a term used to classify a variety of conditions that share in common an injury to the pulmonary vasculature that produces elevations in pulmonary arterial pressure. However, it is the integrity of right ventricular function, rather than the degree of vascular injury, that is the major determinant of symptoms and survival in PAH. The article will review the normal structure and function of the right ventricle and summarize the impact of PAH and its treatments on right ventricular function.
421 citations
TL;DR: This review provides an overview of the current understanding of the role of immune mechanisms in atherosclerosis and suggests that immune modulation as well as immunization can reduce the progression of the disease.
Abstract: Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis consist of macrophages and T cells. Unstable plaques are particularly rich in activated immune cells, suggesting that they may initiate plaque activation. We have seen a rapid increase in the understanding of the mechanisms that govern the recruitment, differentiation, and activation of immune cells in atherosclerosis. Experimental research has identified several candidate antigens, and there are encouraging data suggesting that immune modulation as well as immunization can reduce the progression of the disease. This review provides an overview of our current understanding of the role of immune mechanisms in atherosclerosis. (Arterioscler Thromb Vasc Biol. 2001;21:1876-1890.)
385 citations
TL;DR: Increased vascular superoxide production has now been demonstrated in many different experimental models of hypertension, including spontaneous hypertensive rats, and in cultured endothelial and vascular smooth muscle cells a twoto three-fold increase insuperoxide production is observed after cyclic stretch.
Abstract: Correspondence and requests for reprints to David G. Harrison MD, Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, 319 WMB, Atlanta, GA 30322, USA. Tel: +1 404 727 3710; fax: +1 404 727 3585; e-mail: dharr02@emory.edu Introduction Increased vascular superoxide production has now been demonstrated in many different experimental models of hypertension, including spontaneous hypertensive rats Ž . SHRs 1 , rats with angiotensin II-induced hypertension 2 , rats with aortic banding-induced or renovascuŽ . lar hypertension two kidney one clip model 3,4 and recently also in rats with deoxycorticosterone acetate-salt Ž . DOCA-salt -induced hypertension, that have no systemic activation of the renin angiotensin system 5 . In addition, in cultured endothelial and vascular smooth muscle cells a twoto three-fold increase in superoxide production is observed after cyclic stretch 6 10 .
246 citations
TL;DR: Late stent thrombosis following CYPHERTM DES implantation is observed, with a hypersensitivity reaction around stent struts limited to the polymer with aneurysmal dilatation and extensive inflammation of the arterial wall in the absence of vascular healing.
Abstract: Recent publications on drug-eluting stents (DES) report a significant reduction in restenosis rates as compared to bare metal stents in patients mostly with single vessel disease. We have recently observed however, late stent thrombosis following CYPHER DES implantation. The patient developed a hypersensitivity reaction around stent struts limited to the polymer with aneurysmal dilatation and extensive inflammation of the arterial wall in the absence of vascular healing. This incidence promotes a cautionary view and perhaps supports the use of DES only in high-risk patients.
239 citations
TL;DR: It is suggested that endothelial function is impaired in people with SCF and that CTFC correlates well with endothelial dysfunction.
Abstract: BackgroundSlow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear.DesignThe aim of the study was to determine endothelial function in patients with SCF using a flow-mediated dilatation (FMD) technique in the brachial arte
236 citations