Showing papers in "Current Problems in Cancer in 1992"

TL;DR: Lab studies indicate that long-term treatment schedules may provide maximal benefit in preventing recurrence, and recent analysis of clinical trials demonstrates that between 2 and 5 years of adjuvant tamoxifen therapy provides a survival advantage for postmenopausal women with node-positive breast cancer.

TL;DR: The hypothesis that incessant or repetitious ovulation contributes to the initiation of the disease is explored in detail based on experimental data, epidemiologic information, and the potential for antioncogene inactivation in this interesting cell type.

TL;DR: The development of new approaches to inhibit various aspects of the cascade of events necessary to produce metastasis, notably the inhibition of neovascularization, suggests the real possibility that established metastases may be treated by relatively nontoxic medical therapies.

TL;DR: Clinical trials are now focused on retaining therapeutic efficacy but decreasing the toxicity of treatment in these tumors that frequently affect women in their reproductive ages, and novel new agents that may be capable of reversing drug resistance to platinum compounds and alkylating agents are in progress.

TL;DR: The current state of knowledge regarding the control of blood cell production by specific factors is summarized and the means to answer current uncertainties about the activities and clinical uses of hematopoietic growth factors are formulated.

TL;DR: Effective pain management, nutritional support, and psychosocial support complement effective cancer therapy and must be integrated into each patient's comprehensive cancer care to enhance survival and reduce the burden of cancer for patients and their caregivers.