Journal•ISSN: 0377-8282
Drugs of The Future
Thomson Reuters
About: Drugs of The Future is an academic journal published by Thomson Reuters. The journal publishes majorly in the area(s): Medicine & Cancer. It has an ISSN identifier of 0377-8282. Over the lifetime, 1527 publications have been published receiving 14780 citations.
Topics: Medicine, Cancer, Internal medicine, Agonist, Oncolytic virus
Papers published on a yearly basis
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TL;DR: A review of recent advances in peptide therapy for opportunistic fungal infections to discuss the utility and potential of selected peptides as efficient antifungal drugs with acceptable toxicity profiles.
Abstract: Acquired drug resistance to mycotic infections is rapidly emerging as a major medical problem. Opportunistic fungal infections create therapeutic challenges, particularly in high risk immunocompromised patients with AIDS, cancer, and those undergoing transplantation. Higher mortality and/or morbidity rates due to invasive mycosis have been increasing over the last 20 years, and in light of growing resistance to commonly used antibiotics, novel antifungal drugs and approaches are required. Currently there is considerable interest in antifungal peptides that are ubiquitous in plant and animal kingdoms. These small cationic peptides may have specific targets or may be multifunctional in their mechanism of action. On the basis of recent advances in protein engineering and solid phase syntheses, the utility and potential of selected peptides as efficient antifungal drugs with acceptable toxicity profiles are being realized. This review will discuss recent advances in peptide therapy for opportunistic fungal infections.
136 citations