International Blood Research & Reviews 

About: International Blood Research & Reviews is an academic journal published by Sciencedomain International. The journal publishes majorly in the area(s): Medicine & Internal medicine. It has an ISSN identifier of 2321-7219. Over the lifetime, 229 publications have been published receiving 475 citations.

Antisickling Activity and Membrane Stabilizing Effect of Anthocyanins Extracts from Adansonia digitata L. Barks on Sickle Blood Cells.

Abstract: Background: Parts of baobab tree (Adansonia digitata) including especially the barks are commonly used for their medicinal properties. Aims: The aim of this work is to evaluate the antisickling activity of baobab tree barks, which are used in Congolese traditional medicine to manage Sickle Cell Disease. Study Design: Baobab tree barks was extracted with water by maceration. Phytochemical tests were conducted with standard procedures. Antisickling activity and the minimum concentration of extract required to normalize sickled cells was determined by Emmel test. Place and Duration of Study: This work was done at department of chemistry, Science Faculty, University of Kinshasa (DR Congo), between November 2012 and February 2013. Methodology: The barks collected from Adansonia digitata were dried and powdered. A chemical screening was perform and extraction of anthocyanins done. Antisickling activity Original Research Article Mpiana et al.; IBRR, Article no. IBRR.2014.5.001 199 was evaluated by Emmel test, membrane stability by osmotic fragility test and Fe evolution by following solution absorbance at 630nm. The rate of sickle cell shape normalization was determined at different plant aqueous extract concentrations in order to determine the minimal concentration of extract required to normalize sickle cells. The shape modification was quantitatively evaluated from the values of parameters such as surface, radius and perimeters of sickle blood cells before or after treatment with plant extract using Motic software. Results: The aqueous extract of Adansonia digitata showed an antisickling activity with a maximal normalization rate of 65.7% and a minimal concentration required to normalize sickled cells of 5.0mg/mL. The cell surface, perimeter and radius were significantly different before and after treatment with plant extract. The chemical screening showed the presence of polyphenols among which anthocyanins. The biological activity of this plant would be due to these pigments. The anthocyanins extract have also shown a stabilization effect on sickle blood red cells membranes and a reduction of methemoglobin to hemoglobin effect Conclusion: The results obtained show significant antisickling activity of Adansonia digitata barks thus justifying the use of this plant by traditional healers in Congolese traditional medicine in the management of Sickle Cell Disease.

Anemia and Other Blood Symptoms Related Soil Transmitted Helminthiasis: An Internet Approach of Systematic Literature Study Reported Across Indonesia

Abstract: ackground/Aim: Soil Transmitted Helminthiasis (STH) is still a global major problem, affecting billion vulnerable people of marginalized and unfortunate communities from low to middle level social economic countries. Poor personal hygiene and sanitary practice facilitates its transmission. Children and pregnant women are the most vulnerable group. It causes spectrum of clinical conditions from completely asymptomatic to severe, but anemia and nutritional derangement are the most prominent. Anemia related STH itself was already a huge problem, especially when affected susceptible individuals. In the internet, the data on Indonesia’s prevalence of anemia and other blood symptom related STH with its contributing factors are always considered sparse and incomplete. The aim of this systematic literature study was to provide that data by doing the internet literature searching on Indonesia’s electronic data regarding this condition. Methods: A systematic review was done using popular search engine in the internet. All kind of research study, no matter the design (cross sectional, case control or prospective cohort), that fit with inclusion criteria which is anemia or other blood related symptoms (e.g. eosinophilia) related to STH were included. Result: There were 37 studies found on this issues, from 2001 until 2020. Most studies reported anemia that developed during the course of the disease with the clinical spectrum varies from asymptomatic to severe form. Intestinal parasite, epidemiology, neglected tropical disease, iron deficiency, chronic, hemoglobin

Prevalence of Some Hematological Abnormalities among HIV Positive Patients on Their First Visit to a Tertiary Health Institution in Ethiopia; A Cross Sectional Study

Abstract: Aim: The main objective of this study was to identify the magnitude of hematological abnormalities among HIV patients on their first visit to antiretroviral treatment (ART) centers. Methods: A cross sectional study was conducted among 189 HIV positive patients, visiting University of Gondar Hospital, Ethiopia. Blood sample was analyzed for hematological parameters and CD4 count. Frequencies (%), mean (SD) or median (IQR) were used to summarize data according to the type of variable. Independent sample t -test and chisquare test were used as appropriate and in all cases P<0.05 was considered significant. Results:The mean (±SD) age of the participants was 33.2 (±9.3) years. The prevalence of anemia, leucopenia and thrombocytopenia were 42.3%, 4.8% and 12.7% respectively. Immunosupression was found in 83.1% of the individuals. CD4 count with leucopenia (P<0.0001) was the factor that showed significant association.