Showing papers in "Journal of Ethnopharmacology in 2023"

TL;DR: The main objective of as discussed by the authors was to evaluate the HDI potential of plants commonly used as ingredients in many herbal products, including BDS, and the results indicate that prolonged or excessive consumption of herbal preparations rich in such plants (presented in Figs. 1a, 2a, 3a, 4a, 5a, and 5a) may pose a risk for CYP- and P-gp-mediated HDIs, leading to unwanted side effects due to the altered pharmacokinetics of concomitantly ingested medications.

TL;DR: In this paper , the authors summarized the present application status and existing problems of network pharmacology in the field of Chinese medicine formula, and formulates the research ideas, up-to-date key technology and application method and strategy.

TL;DR: In this article , the inhibitory role of Artemisia argyi methanol extract (Aa-ME) in inflammatory responses and the underlying mechanism in macrophages was explored.

TL;DR: Xianglian Pill (XLP) is a classical Chinese medicine prescription applied for controlling ulcerative colitis (UC). Whereas, the underlying mechanism remains unclear, this article investigated the mechanism of XLP in dextran sulfate sodium (DSS)-induced UC via the Toll Like Receptor 4 (TLR4)/Myeloid Differentiation factor 88 (MyD88)/Nuclear Factor kappa-B (NF-κB) signaling in mice.

TL;DR: A review of the traditional medicinal properties, phytochemistry, pharmacology, and purification technologies of Bambusoideae can be found in this article , where more than 100 chemical compounds, including flavonoids and flavonoid glycosides, volatile components, phenolic acids, polysaccharide, coenzyme Q10, phenylpropanoid and amino acids have been reported to be present.

TL;DR: In this article , the effect of Pulsatilla decoction (PD) on colitis in mice was evaluated using a 3% DSS-induced ulcerative colitis model in C57BL/6 male mice.

TL;DR: Wang et al. as mentioned in this paper investigated the mechanisms of Jingfang granule (JFG) in treating urticaria through an OVA/aluminum hydroxide induced URticaria mice model, and the results of proteomics, central carbon metabolomics, western blot and immunohistochemical staining confirmed that JFG inhibited Glycolysis/Gluconeogenesis and Pentose phosphate pathway.

TL;DR: In this paper , a UPLC-Q-TOF-MS analytical method was developed and applied to detect 16 major bioactive components in normal and acute blood stasis (ABS) rats following oral administration of Taohong Siwu Decoction.

TL;DR: In this article , the authors evaluated the expression and role of the SIRT1-FoxO-1 pathway and autophagy levels in endometriosis (EM) rats, and the therapeutic effects and potential therapeutic mechanisms of BWHD were also investigated.

TL;DR: In this article , a systematic summary on the traditional use, chemical constituents, pharmacological effects, clinical applications, quality control, toxicology, and pharmacokinetics of Ephedrae herba is provided.

TL;DR: Xiaochaihu Tang (XCHT) is a traditional formula combined of seven herbs, which was first recorded in the Treatise on Febrile Diseases in Han Dynasty of ancient China as discussed by the authors .

TL;DR: In this paper , a focused literature review methodology was utilized for exploring the data from various scientific platforms such as Science Direct, Wiley Online Library, Springer, PubMed, Google Scholar using "pharmacovigilance, herbal medicine, traditional medicine, ADR, under reporting, herb toxicity, herb interactions" as keywords along with standard literature pertaining to herbal medicines that is published by the WHO and other international and national organizations etc.

TL;DR: Wang et al. as mentioned in this paper systematically reviewed the ethnopharmacology, botany, phytochemistry, pharmacology and related applications research of polygonati rhizoma (PR), and provided a reference for the comprehensive applications of PR, including basic research, product development and clinical applications.

TL;DR: Wang et al. as mentioned in this paper used UPLC-Q-Exactive Orbitrap MS platform to identify a total of 29 chemicals in serum, 17 of which were highly linked with effectiveness and can be potentially employed as pharmacodynamic substances for BHP against DR.

TL;DR: In this paper , the effects and mechanisms of curcumol intervention in human uterine leiomyoma cells (UMCs) were identified using network pharmacology strategies, and molecular docking was performed to assess the binding affinity of Curcumol to core targets.

TL;DR: In this article , the authors measured the IC50 of stored (frozen) dried-leaf hot-water A. annua extracts against SARS-CoV-2 variants: original WA1 (WT), BA.2, BA.1, and BA.4.

TL;DR: In this paper , a comprehensive overview of herb-drug interactions is provided by analyzing the results of the in vivo and in vitro studies on P. notoginseng and its bioactive components.

TL;DR: In this article , Wei-Tong-Xin (WTX) derived from the Chinese herbal decoction (CHD) of Wan-Ying-Yuan in ancient China, has been shown to be effective therapeutic herbal decocction for treating gastrointestinal diseases.

TL;DR: Wang et al. as discussed by the authors investigated the effective materials and molecular mechanisms of Lagotis integra W. W. Smith treating UC, which contributes to the understanding of its pharmacodynamics.

TL;DR: Wang et al. as mentioned in this paper validated the mechanism of DDD in AS and HLP based on network pharmacology and in vitro experiments, and they showed that DDD effectively reduced lipid accumulation in FFA-treated L02 cells, DDD attenuated mitochondrial damage and reduced ROS content; DDD inhibited ferroptosis and apoptosis, and DDD upregulated the expression of HIF-1α, Glutathione Peroxidase 4(GPX4), and Bcl2 proteins, and downregulated expression of Bax protein.

TL;DR: Cordyceps proteins (CP) have a favorable bidirectional immunomodulatory functions and may have therapeutic potential for lupus nephritis (LN) as discussed by the authors .

TL;DR: In this article , Eryngium rhizome extracts were obtained from plants growing in Mallorca (Balearic Islands), and its composition was determined using HPLC-DAD, highlighting simple phenolic compounds such as trans-ferulic acid, catechin, chlorogenic acid, epicatechin and rosmarinic acid as the major constituents.

TL;DR: Wang et al. as mentioned in this paper explored the therapeutic effect of SQJTG on diabetic nephropathy (DN) through both bioinformatics analysis and in vivo experiments, and the results showed that the treatment significantly ameliorated STZ-induced kidney damage and had a dosage dependence.

TL;DR: Shaoyao-Gancao Tang (SGT) is a traditional Chinese medicine formulation as mentioned in this paper , which has been used to treat kinds of pain and to alleviate asthma in clinic.

TL;DR: In this paper , a review of the methods for obtaining mulberry leaves' bioactive components, elaborates on the clinical potential of the relevant components in managing type 2 diabetes mellitus (T2DM), and focuses on the therapeutic mechanisms of gut microbiota, inflammation, oxidative stress, and metabolism, to provide more inspiration and directions for future research in the field of traditional natural plants for the management of T2DM.

TL;DR: In this article , the authors explored the role of SCFAs in the DZSM-mediated treatment of cerebral ischemia and found that the increased intestinal SCFA levels also contributed to the repair of the 2VO-induced disruption of gut barrier integrity and inhibited the translocation of lipopolysaccharide from the intestine to the brain, thus attenuating neuroinflammation.

TL;DR: The effect of koumine on macrophage polarization was investigated in vivo and in vitro in this article , and it was shown that koumin had therapeutic effects on CIA mice and inhibited the PI3K/AKT signaling pathway.

TL;DR: In this article , the main active components of DR in the treatment of osteoarthritis by spectrum-effect relationship and compare the differences between RDR and WDR were found. But, there are few reports on the DR main active ingredients.

TL;DR: In this article , a network pharmacology approach was used to predict the components and targets of Taohongsiwu decoction for treating hypertension, and 205 targets were identified and regarded as potential targets of THSWD in HN treatment.

TL;DR: In this article , the antibacterial and antibiofilm activities of the preferred fractions and compounds from E. humifusa against Staphylococcus aureus and the associated mechanism of action were investigated.