Journal of Natural Remedies 

About: Journal of Natural Remedies is an academic journal published by Informatics Publishing Limited. The journal publishes majorly in the area(s): Medicine & Chemistry. It has an ISSN identifier of 0972-5547. It is also open access. Over the lifetime, 717 publications have been published receiving 4583 citations.

Evaluation of Evolvulus alsinoides Linn. for Anthelmintic and Antimicrobial Activities

Abstract: Objective: To study the anthelmintic and antimicrobial activities of the ethanolic extract of Evolvulus alsinoides Linn. Materials and methods: The anthelmintic activity was evaluated on adult Indian earthworm Pheretima posthuma due to its anatomical and physiological resemblance with the intestinal roundworm parasites of human beings. The antibacterial activity of the crude ethanolic extract was performed by agar cup plate method. Results: The ethanolic extract caused paralysis followed by death of the worms at all tested dose levels. It was observed that the ethanolic extract of Evolvulus alsinoides is more potent than the reference control piperazine citrate. Potency of the extract was inversely proportional to the time taken for paralysis/ death of the worms. The activity confirms the dose dependency nature of the extract. The results of antimicrobial activity revealed that the extract exhibited activity against Pseudomonas aeruginosa and Escherichia coli but inactive against Staphyloccus aureus and Candida albicans . None of test concentrations exhibited comparable activity with the reference control ampicillin trihydrate. Conclusion: The present study concludes that the plant is also endowed with potential anthelmintic property in addition to its other popular uses in the traditional system of medicine.

An Overview on Ajwain ( Trachyspermum ammi ) Pharmacological Effects; Modern and Traditional

Abstract: Trachyspermum ammi (L.) Sprague or commonly Ajwain is a herbaceous herb belonging to the family Apiaceae and vastly grows in Egypt, Iran, Pakistan, Afghanistan, and India as well as European region. Known as Zenyan or Nankhah in medical and pharmaceutical manuscript of medieval Persia, seeds of Ajwain were highly administered by traditional healers and traditionally employed for different ailments. Due to its various chemical constituents, the herb seeds were also evaluated for its numerous pharmacological properties. Accordingly, current work was carried out to review the traditional and modern pharmacological properties of Ajwain regarding current and medieval reports. To this, respective databases were searched for the terms ' Trachyspermum ammi ', ' Carum copticum ', 'Ajwain' and 'Ajowan' without limitation up to early 2013. Information on the herb was gathered via electronic search using Pubmed, Scopus, Google scholar and SID (for articles in Persian language) as well as medical and pharmaceutical manuscripts of Persian medicine. Ajwain seeds revealed to possess antiseptic, stimulant, carminative, diuretic, anesthetic, antimicrobial, antiviral, nematicidal, antiulcer, antihypertensive, antitussive, bronchodilatory, antiplatelet and hepatoprotective as well as antihyperlipidemic effects, many of those were remarked by early Persian physicians. With reference to these pharmacological activities, Ajwain seeds can be a good candidate for to be applied in clinical practice. However, in spite of various experimental and animal studies, lack of comprehensive clinical trials aimed on regarded effects is still remained to reconfirm the traditional knowledge.

Antioxidant and Anti Aging Assays of Oryza Sativa Extracts, Vanillin and Coumaric Acid

Abstract: Aging is a natural process in humans as accumulation of oxygen-derived free radicals which leads to the activation of hyaluronidase, collagenase and elastase, that can further contribute to cellular and tissue damage. Bioactive compounds from plants have been used as antioxidant that might inhibit aging processes as well. This study aimed to determine antioxidant and anti aging properties of Oryza sativa Extract (OSE), and its compounds, vanillin and coumaric acid. The phytochemical analysis of OSE was performed with Farnsworth modified method. Antioxidant activities were performed by measurement of 2,2-diphenyl 1-pichylhydazyl (DPPH) free radical scavenger, Ferric Reducing Antioxidant Power (FRAP), and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) reducing activity, while anti aging assay were observed through inhibitory of elastase, collagenase, and hyaluronidase activities. Phytochemical analysis showed the presence of terpenoids and saponins in high level. OSE showed lowest DPPH activity (IC 50 = 314.51 μg/mL) compared to vanillin (IC 50 = 283 μg/mL) and coumaric acid (IC 50 = 255.69 μg/mL). In ABTS assay, OSE resulted lowest activity(IC 50 = 145.67 μg/mL), compared to vanillin (IC 50 = 4.96 μg/mL) and coumaric acid (IC 50 = 1.67 μg/mL). OSE also showed the lowest FRAP-reducing activity (21.26 μM Fe(II)/μg), compared to vanillin (35.05 μM Fe(II)/μg) and coumaric acid (48.52μM Fe(II)/μg). OSE showed the lowest collagenase, elastase, and hyaluronidase inhibitory activity (IC 50 = 816.78,107.51, and 203.13 μg/mL), compared to vanillin (IC 50 = 16.27, 14.46, 45.23 μg/mL respectively) and coumaric acid (IC 50 = 146.89, 25.38, 8.21 μg/mL respectively). In summary, OSE possess the lowest antioxidant and anti aging activities compared to vanillin and coumaric acid.

A Comprehensive Review on Ocimum basilicum

Abstract: The genus Ocimum has a number of species that are used to treat different types of disorders and diseases from ancient times. In this genus, O. basilicum plays a vital role due to its various medicinal properties. It is universally cultivated as herbaceous, perennial plant but originated from Asian continent. O. basilicum is used as a culinary herb and also has a number of pharmacological activities to prevent or treat cardiovascular disorders, diabetes, menstrual cramps, digestive disorders, neuro-degenerated disorders and cancer. In addition to that, it has been reported for antioxidant, antimicrobial, and larvicidal activities. Chemical constituents such as linalool; eugenol; 1, 8-cineone; methyl eugenol and anthocyanins are mostly responsible for the above mentioned activities. Some traditional uses of this plant coincidences with experimental results. However, the studies conducted based on its traditional use are negligible. This review is an attempt to provide a pharmaceutical perspective of Ocimum basilicum.

A Review of Medicinal Plants of the Genus Cordia : Their Chemistry and Pharmacological Uses

Abstract: The plants of genus Cordia comprise of trees and shrubs which are widely distributed in warmer regions. The plants of this species have long been used in traditional and folk medicine for treating various illnesses. Some plants in this species were exhaustively explored and some others are yet to be. Substantial progresses on their chemical and pharmacological properties of some species have been made. In India, the fruits of this species are consumed as vegetable. The pharmacological studies carried out with extracts and purified compounds indicates that the plants of Cordia species posses analgesic, anti-inflammatory, antimicrobial, antiviral and antifertility activities. Various compounds like flavonoids, triterpenes, tannins, alkaloids and fatty acids possessing wide range of bioactivities were isolated from different plant parts of Cordia species. Based on these reports it is clearly indicated that the plants of Cordia genus possess potential therapeutic actions.