Journal•ISSN: 0030-6002
Orvosi Hetilap
Akadémiai Kiadó
About: Orvosi Hetilap is an academic journal published by Akadémiai Kiadó. The journal publishes majorly in the area(s): Medicine & Population. It has an ISSN identifier of 0030-6002. Over the lifetime, 9425 publications have been published receiving 26823 citations. The journal is also known as: Hungarian medical journal.
Topics: Medicine, Population, Internal medicine, Diabetes mellitus, Pregnancy
Papers published on a yearly basis
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Journal Article•
TL;DR: The author gives a short review of the most important prognostic factors in breast cancer, with emphasis was laid on steroid receptors, c-erpB-2, p53 and bcl-2 alterations.
Abstract: Prognostic factors are clinical and pathological features that give information in estimating the likely clinical outcome of an individual suffering from cancer. The author gives a short review of the most important prognostic factors in breast cancer. 376 breast cancer cases of a ten year interval in a county hospital are summarized. Traditional clinico-pathological parameters i.e. TNM and steroid receptor status are discussed. The more common karyotipic, oncogene and tumor suppressor gene alterations are outlined in the study. Methods for their detection are presented and their value in prognostication is reviewed. Emphasis was laid on steroid receptors, c-erpB-2, p53 and bcl-2 alterations. Genes responsible for heritable forms of increased breast cancer risk are briefly reviewed.
609 citations
TL;DR: The wide use of drugs for renal protection in general and the long term administration of steroid therapy in some primary (idiopathic) cases are new elements among the therapeutic possibilities.
Abstract: A focalis segmentalis glomerulosclerosis fenymikroszkopos vizsgalattal lathato jellegzetes morfologiaju glomeruluskarosodas, tobbfele szovettani altipussal es valtozo klinikai keppel. A kulonboző szovettani variansokat ujabban rendszereztek (Columbia-klasszifikacio). A glomeruluskarosodas mindegyik variansnal a podocytakat erinti, ezert ujabban a focalis segmentalis glomerulosclerosist a podocytopathiak fő tipusanak tartjak. A primer (ismeretlen eredetű) formak mellett egyre nő a secunder focalis segmentalis glomerulosclerosisok szama is. A terapias lehetősegek kozott uj elem az altalanos vesevedő kezeles kiterjedt alkalmazasa es egyes primer idiopathias esetekben a szteroidkezeles megnyujtasa.
314 citations
Journal Article•
TL;DR: It is suggested that the presence of an intrauterine hematoma during the first trimester may identify a population of patients at increased risk for adverse pregnancy outcome.
Abstract: AIMS To evaluate the long-term clinical significance of intrauterine hematomas detected in the first trimester of pregnancy in a general obstetric population. METHODS A prospective study was designed to compare the perinatal outcome in 187 pregnant women with intrauterine hematomas to 6488 controls in which hematomas were not detected at first trimester by ultrasound examination. RESULTS The incidence of intrauterine hematoma in the first trimester in a general obstetric population was 3.1%. A retroplacental position of the hematoma was significantly correlated with an increased risk for adverse maternal and neonatal complications. The presence or absence of symptoms of threatened abortion did not affect these outcomes. The rates of operative vaginal delivery (RR: 1.9; CI: 1.1-3.2) and cesarean section (RR: 1.4; CI: 1.1-1.8) were significantly greater in the hematoma group as compared to the control group, as well as the rates of pregnancy induced hypertension (RR: 2.1; CI: 1.5-2.9) and preeclampsia (RR: 4.0; CI: 2.4-6.7). Placental abruption (RR: 5.6; CI: 2.8-11.1), and the incidence of placental separation abnormalities was also significantly more frequent in the hematoma group (RR: 3.2; CI: 2.2-4.7). Perinatal complications, including the rate of preterm delivery (RR: 2.3; CI: 1.6-3.2), intrauterine growth restriction (RR: 2.4; CI: 1.4-4.1), fetal distress (RR: 2.6; CI: 1.9-3.5), meconium stained amniotic fluid (RR: 2.2; CI: 1.7-2.9), and NICU admission (RR: 5.6; CI: 4.1-7.6) were also significantly increased in this group. Furthermore, the frequency of intrauterine demise and perinatal mortality was increased in the hematoma group, but this difference did not reach statistical significance (p = 0.6 and p = 0.2). CONCLUSION The authors' study suggests that the presence of an intrauterine hematoma during the first trimester may identify a population of patients at increased risk for adverse pregnancy outcome.
135 citations
Journal Article•
TL;DR: The fatal case presented underlines the importance that within the clinical pattern of myopathies the distinct entities should be differentiated.
Abstract: Cytochrome c oxydase deficiency, i.e. a mitochondrial myopathy was diagnosed in a patient suffering from generalized muscle hypotonia. The fatal case presented underlines the importance that within the clinical pattern of myopathies the distinct entities should be differentiated.
122 citations