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Showing papers in "The American Journal of Medicine in 1950"







Journal ArticleDOI
TL;DR: Changes have been observed in the venous clotting time and the heparin-retarded venous clots time which indicate that ACTH and cortisone frequently produce a hypercoagulable state of blood coagulation.

150 citations


Journal ArticleDOI
TL;DR: A syndrome of jaundice with distinctive features is described in association with methyl testosterone therapy, characterized by a negative cephalin-flocculation reaction, only moderately elevated serum alkaline phosphatase and a markedly increased serum bilirubin.

125 citations



Journal ArticleDOI
TL;DR: The subjects with abnormal mental status resulting from cerebral vascular disease had significantly lower cerebral blood flows, cerebral oxygen and glucose utilizations and higher cerebrovascular resistances than those with normal mental status or than normal young subjects.

104 citations


Journal ArticleDOI
TL;DR: Five cases of massive obstruction to pulmonary arteries with the development of chronic cor pulmonale are presented and angiocardiography in one case demonstrated obstruction to the left pulmonary artery.

93 citations




Journal ArticleDOI
TL;DR: The focal myocardial necrosis, cellular infiltration and fibrosis, focal endocarditis and marked hydropic degeneration of the renal tubules found at necropsy are identical to those lesions reported in potassium deficient animals.

Journal ArticleDOI
TL;DR: The symptom patterns of the hyperventilation syndrome have been discussed and an attempt has been made to correlate these symptoms and the physiologic processes responsible for them.

Journal ArticleDOI
TL;DR: The literature on cryptococcosis has been reviewed and 165 reported cases have been collected including two cases of the patient's own, and 14 of these patients have had coincident Hodgkin's disease.

Journal ArticleDOI
TL;DR: The kidney participates in the regulation of body neutrality by stabilizing the plasma concentration of bicarbonate-bound base at a level of 25 to 27 mEq.


Journal ArticleDOI
TL;DR: In this paper, the effects of hospitalization per se in eighty-six patients observed for a mean period of nine weeks on a standardized regular diet were evaluated in a hospital environment.

Journal ArticleDOI
TL;DR: The conclusion was reached that antiserum seems to have definite value and should be applied in every case of exposure to rabies, in conjunction with a short course of vaccine treatment.

Journal ArticleDOI
TL;DR: The available evidence does not appear to justify the view that the pituitary and/or adrenal glands play a central role in the pathogenesis of gout, and the use of ACTH is neither feasible nor desirable at present.

Journal ArticleDOI
TL;DR: It was suggested that congenital thrombocytopenic purpura might be the result of the transfer of an immune body, hormone or other substance across the placental membrane which depresses platelet formation in the infant.

Journal ArticleDOI
TL;DR: It can be easily seen that age, sex, pre-existing hypertension, angina and previous infarction materially influence mortality and the state of the heart at the time of infarctions must be weighed in statistical analysis of the effectiveness of any therapeutic procedure.

Journal ArticleDOI
TL;DR: The clinical manifestations of fifty-four patients with sickle cell anemia admitted to the charity hospitals of this area during the past ten years are presented and Hematologic studies indicate continued hyperactivity of the bone marrow and a disappearance of symptoms of this disease without persistent elevation of the erythrocyte count.

Journal ArticleDOI
TL;DR: Correlation of history, physical examination, function studies and therapeutic response suggests hepatic dysfunction was responsible for abnormal carbohydrate metabolism in fifteen patients, liver dysfunction was secondary to diabetes in forty-eight patients and liver disease and diabetes were coincidental in two patients.

Journal ArticleDOI
TL;DR: Evidence is presented which indicates that pulmonary hypertension in emphysema is related to an increased vascular resistance in the lungs, and no evidence was found to indicate that oxygen unsaturation of the arterial blood in empysema induces an increase in the output of the heart.


Journal ArticleDOI
TL;DR: A review of instances of ruptured papillary muscle of the heart was made by Wood et al. as discussed by the authors, where tentative criteria based upon deductions from the data in thirty-seven cases were suggested for the antemortem diagnosis.