Showing papers in "The American Journal of Medicine in 1959"

TL;DR: The general principles formulated in this paper may be summarized as follows: What is experienced and reported as pain is a psychological phenomenon and disordered neural patterns originating in the periphery confer certain qualities on the pain experience that permit the physician to recognize their presence and hence make a presumptive diagnosis of an organic lesion.

TL;DR: The purpose of this review is to re-examine and to some extent revise prevailing concepts of the body content and distribution of water, sodium, potassium and chloride in man.

TL;DR: A graphical summary of those aspects of carbohydrate metabolism herein discussed, which contribute to the regulation of blood glucose under normal and pathological conditions, is presented in Figure 9.

TL;DR: Present evidence indicates that membrane transport is predominantly rate-limiting in the absence of insulin and that the hormone accelerates this step.

TL;DR: A number of obscure outbreaks of paralytic illness are reviewed, the majority of which were at first confused with poliomyelitis but which were later differentiated on clinical and epidemiologic grounds.

TL;DR: It is evident that in insulin therapy, avoidance of hypoglycemia, even of mild, asymptomatic degrees, is no less important than the control of excessive hyperglycemia and glycosuria, which makes it possible to forestall the development of severe states of diabetes.

TL;DR: T HE blood plasma of normal man contains representatives of two classes of “nonspecific” phosphomonoesterases, one exhibiting optimum activity at pH ca. 9 with substrate in high concentration [I+?], the other at pH 5 [3], hence their designation, conveniently if inexactly, as alkaline and acid phosphatases.

TL;DR: The effects on creatine excretion of ACTH and 17-hydroxycorticosteroid therapy in patients with progressive muscular dystrophy and inflammatory muscle disease suggest that increased creatine synthesis together with decreased ability to store creatine may be responsible for the creatinuria observed in the patients with steroid myopathy.

TL;DR: No antecedent encephalitic or meningoencephalitic illness or any other acute infectious disease has been identified in the study of Kuru and no nutritional or toxic factor has been incriminated as of possible etiological significance in the disorder.

TL;DR: There remain today numerous unanswered questions in this field, especially in regard to the relationship between glycolysis and the synthesis of ketone bodies and of cholesterol.

TL;DR: Although all the intestinal lesions appeared to be inflammatory, no specific pathological classification was possible and the possibility exists that the hypoproteinemia is a consequence of excessive loss of serum protein into the intestine.

TL;DR: An analysis of 123 culturally proved cases of histoplasmosis is presented, finding that this infection characteristically progresses gradually over several years, although remissions and exacerbations may occur.

TL;DR: Chlorothiazide was given intravenously to a group of normal human subjects and to one patient with diabetes insipidus, and its effects on renal function were compared with those of meralluride administered under similar circumstances, suggesting the presence of more than one renal transport mechanism concerned with the reabsorption of strong monovalent electrolytes.

TL;DR: The evidence cited indicates that it is possible to distinguish fairly clearly between the acid phosphatase of the prostate and that of the erythrocytes, but differences between prostatic phosphatases from some other sources appear to be less clear-cut.

TL;DR: One hundred fifty-four patients with psoriasis and various rheumatic complaints have been studied and the clinical features of this group have been analysed and compared.

TL;DR: Knowledge of the forces involved in nearly periodic wake fluctuations allows more complete understanding of the stresses that may lead to degeneration of cardiovascular structures.

TL;DR: The clinical responses were excellent in four patients with cryptococcal meningitis who received hyperimmune gamma globulin twice weekly, intravenous and intrathecal amphotericin B, and who were maintained on low thiamin diets.

TL;DR: The present study was undertaken to evaluate the oral d-xylose test and to compare it with other indices of absorption in patients with malabsorption of varying etiology, and to facilitate an understanding of the biologic significance of the xylOSE test and its validity in evaluating intestinal absorption.

TL;DR: Postmortem examination revealed extensive intravascular sickling with the formation of conglutinative thrombi in the lungs, liver, kidneys, adrenals and brain, and a possible pathogenetic sequence is suggested, emphasizing the release of fat from infarcted bone marrow.

TL;DR: Vitamin B 6 deficiency, characterized by failure of growth, emaciation, convulsions, anemia and oxalate nephrocalcinosis, has been produced in cats and the presence of large quantities of Oxalate in the kidneys and urine of cats deficient in vitamin B 6 is attributable to excessive endogenous formation of oxalates.

TL;DR: Plasma amylase determinations remain the most important laboratory aid in the diagnosis of acute pancreatitis or of acute exacerbations of chronic pancreatitis, although the peripheral levels of amylases do not accurately mirror the severity of the pathologic process.

TL;DR: The question of the demonstration of a circulating neuromuscular blocking agent in myasthenia gravis is discussed with reference to: methods of bioassay, results reported in this paper and by other investigators, possible properties of such a blocking agent, and clinical status of the myASThenic patient.

TL;DR: It seems advisable to administer amphotericin B every other day in order to lessen the untoward toxic effect of this drug, as there is increasing evidence of occurrence of a subclinical pulmonary form of North American blastomycosis, resembling the benign lung form of coccidioidomycotic and histoplasmosis, which may be more prevalent than is generally thought.

TL;DR: Markedly reduced erythrocyte acetylcholinesterase activity was demonstrated in all eight cases of paroxysmal nocturnal hemoglobinuria studied and the significance of the defective enzyme activity in the PNH cell is discussed.

TL;DR: It is concluded that the association of these familial disorders of the neurectoderm with pheochromocytoma is not only helpful in the clinical diagnosis of p heochromocrytoma, but strengthens the concept that they are all related disorders of those structures of ectodermal origin.