Showing papers in "The American Journal of Medicine in 1963"

TL;DR: Evidence suggests that absence of serum inhibitor of C′1-esterase is an inherited abnormality in those with the familial type of angioneurotic edema, and this determination may permit identification of young family members who will have attacks of swelling later in life.

TL;DR: No statistically significant difference in sarcoid manifestations was found primarily due to sex or race except for a higher incidence of hypoalbuminemia and hyperglobulinemia in Negro subjects.

TL;DR: The nature of the biochemical defect, a deficiency of homogentisic acid oxidase, in alcaptonuria is described and the pattern of genetic transmission traced; the geographic and racial distribution, and the multisystemic clinical manifestations of ochronosis are summarized.

TL;DR: Evidence is presented to show that a large part of the fructose assimilated by these patients may be metabolized by adipose tissue, and the earlier hypothesis of a primary defect in fructose-1-phosphate splitting liver aldolase has been proved by direct enzyme analysis of liver tissue of both patients.

TL;DR: Impaired antibody response and low levels of normal gamma globulin components indicate that reduction of normal plasma cell function is a prominent feature in multiple myeloma and macroglobulinemia and appears to reflect some other feature of plasmacytic and lymphocytic malignancy.

TL;DR: Following an attempt at resection of the carcinoma it is suggested that the excretion of steroids in the urine be examined at frequent intervals so that metastasis may be detected early and treatment initiated.

TL;DR: It is suggested that the adrenergic nervous system plays an important compensatory role in the circulatory adjustments of patients to congestive heart failure, and the need for caution in the use of highly effective antiadrenergic drugs in the treatment of patients with limited cardiac reserve is emphasized.

TL;DR: The pattern of peptic ulcer and tumors of the anterior pituitary gland, parathyroid glands and islets of Langerhans must now be augmented to include adenomas of the thyroid and of the adrenal cortex, as well as lipomas in various locations, since these latter occur in the syndrome with significant frequency.

TL;DR: A careful bacteriologie study of brain abscesses of nontraumatic origin found that a pre-existing focus of chronic infection in the ear, sinus or lung was clearly recognizable, which probably explains the high incidence of anaerobes and suggests that these organisms may be the important pathogens in all brain abscessiones of similar origin.

TL;DR: Although the exact cause of these cases was not identified, the time pattern of their occurrence and the parallel appearance of a "rheumatic-like" illness suggest an etiologic relationship to infection.

TL;DR: It was found that mycosis fungoides almost always began as a chronic benign dermatitis, and in six patients serial biopsies showed transition from benign lymphadenopathy to frank malignant lymphoma.

TL;DR: The findings indicate that gynecomastia occurs in men with endocrine imbalance and suggest estrogenic preponderance and the suggestion is advanced that endocrine investigation in adult men include a biopsy of the breasts.

TL;DR: Vasovagal reactions which developed in the course of cardiac catheterization were studied in thirteen patients, and a uniform fall in heart rate, arterial blood pressure, cardiac index and total systemic resistance was noted.

TL;DR: It is suggested that the genetic basis of common diseases is intrinsically different from the Genetic basis of rare diseases and that the methods of genetic analysis which have been used with such power in the study of rare disease are not necessarily relevant to the studyof common diseases.

TL;DR: The mortality is found to rise from 3 per cent in patients with slight or cured underlying disease, to 80 per centin patients with severe, complicated underlying disease and the mortality increases significantly within the higher age group.

TL;DR: Of a total of sixty-six patients with renal papillary necrosis, only five had diabetes and eight had urinary tract obstruction, whereas fifty-three had neither diabetes nor urinary tract obstruct, whereas the latter group was characterized by a preponderance of young women nearly all of whom were great consumers of analgesics.

TL;DR: Review of 148 cases of chronic meningococcemia reported in the U. S. reveals that this disease has a definite symptom complex which should be readily recognized and sulfadiazine therapy is specific, prompt and dramatic.

TL;DR: It was found that the activity resided in a heat-stable euglobulin fraction and that reactivity in the latex fixation test could be destroyed upon treatment with mercaptoethanol, suggesting a relationship between age and incidence of these globulins.

TL;DR: It is suggested that the abnormality in glutamine metabolism described may have significance for the pathogenesis of primary gout and a defect in utilization of glutamine for renal production of ammonia (? glutaminase deficiency) might enhance uric acid production by recycling extra glutamine into the first and apparently rate-determining reaction of de novo purine biosynthesis, and moreover would predispose to uric Acid stone formation.

TL;DR: The diagnosis of isolated stenosis of the pulmonary artery branches is to be considered in a patient with evidence of right ventricular preponderance and an atypical, frequently distant, holosystolic, or less often, quasicontinuous murmur in the second intercostal spaces well transmitted to the lungs.

TL;DR: The data indicate a seasonal variation in the incidence of hypercalcemia which correlates well with the amount of natural ultraviolet radiation available at that particular time of year.

TL;DR: The clinical findings of brisk arterial pulses, loud fourth heart sounds, ejection systolic murmurs and evidence of left ventricular hypertrophy on clinical, electrocardiographic, roentgenologic and angiocardiographic examinations were similar to the findings in patients with idiopathic hypertrophic subaortic stenosis, however, none of the patients described in this report exhibited any hemodynamic evidence of obstruction to blood flow during the control state.

TL;DR: In this paper, needle-like cytoplasmic inclusion bodies were found in the proximal tubular epithelium of the kidney and plasma cells of bone marrow and peripheral blood.

TL;DR: A case is reported of chronic massive thromboembolic occlusion of major pulmonary arterial branches successfully treated with embolectomy and endarterectomy.

TL;DR: The most consistent abnormalities encountered during laboratory investigations were changes in the cerebrospinal fluid and a pleocytosis was present in 81 per cent of the cases in which cell counts were reported, and in 65 per cent protein levels were greater than 50 mg.