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Charles S. Lieber
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 647
Citations - 51413
Charles S. Lieber is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Ethanol metabolism & Ethanol. The author has an hindex of 120, co-authored 647 publications receiving 50420 citations. Previous affiliations of Charles S. Lieber include University of Erlangen-Nuremberg & Veterans Health Administration.
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High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism.
TL;DR: It is concluded that the increased bioavailability of ethanol resulting from decreased gastric oxidation of ethanol may contribute to the enhanced vulnerability of women to acute and chronic complications of alcoholism.
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Cytochrome P-4502E1: its physiological and pathological role
TL;DR: 2E1 has a unique capacity to activate many xenobiotics to hepatotoxic or carcinogenic products, mainly as a monooxygenase and secondarily via hydroxyl radicals, with transcriptional and posttranscriptional regulation.
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Hepatic Microsomal Ethanol-oxidizing System: IN VITRO CHARACTERISTICS AND ADAPTIVE PROPERTIES IN VIVO
TL;DR: The existence of a microsomal ethanol-oxidizing system, especially its capacity to increase in activity adaptively after ethanol feeding, may explain various effects of ethanol, including proliferation of hepatic smooth endoplasmic reticulum, induction of other hepaticmicrosomal drug-detoxifying enzymes, and the metabolic tolerance to ethanol which develops in alcoholics.
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The Feeding of Alcohol in Liquid Diets: Two Decades of Applications and 1982 Update
TL;DR: Variations of the liquid diet formulation are compared and three standardized basic formulas are being proposed for the rat, suitable for most experimental applications, particularly those intended to mimic the clinical situation in which the various effects of alcohol occur in the setting of liver changes characterized by a fatty liver.
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Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
TL;DR: Prevention and therapy opposing the development of steatosis and its progression to more severe injury can be achieved by a multifactorial approach: control of alcohol consumption, avoidance of obesity and of excess dietary long-chain fatty acids, and replenishment of S-adenosylmethionine and PCs by using PPC.