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Long-chain functional bisphosphonates: synthesis, anticalcification, and antiresorption activity
Ravit Chen,Ada Schlossman,Eli Breuer,Gerhard Häagele,Christian Tillmann,Joel M. Van Gelder,Gershon Golomb +6 more
TL;DR: The unique effect of the α-keto groups in rendering long-chain bisph phosphonates active is presumably attained through a combination of chelating ability with sufficiently low pKa values to enable the bisacylphosphonate molecules to be fully ionized at physiological pH.