Journal ArticleDOI
A collaborative study for the evaluation of a serologic test for primary liver cancer
TLDR
The alpha‐fetoprotein test has proven to be highly specific for primary liver cell cancer and may be used with advantage in differential diagnosis of this disease and in epidemiologic studies.Abstract:
Sera from 813 patients were examined independently by 3 test centers for the presence of alpha-fetoprotein (AFP). The sera were collected at 5 different African centers and 2 non-African centers. There was disagreement in the serologic results among the 3 test laboratories in only 27, or 3.3%, of cases. A clinical and/or histologic diagnosis of primary liver cancer had been made in 231 of the cases in which there was serologic agreement, and 151, or 65.4%, of these were positive for AFP. If only those cases with histologic confirmation of liver cell cancer were included, the percentage of cases with AFP increases to 75%. Analysis of the results from each collection center has been made, and the basis for “false-positives” and serologic disagreements is discussed. The test has proven to be highly specific for primary liver cell cancer and may be used with advantage in differential diagnosis of this disease and in epidemiologic studies.read more
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Book ChapterDOI
Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors
TL;DR: This chapter emphasizes the importance of basic research on the alpha–fetoprotein (AFP) phenomenon; such studies, aimed to decipher its nature, contribute to the understanding of both normal ontogenesis and pathogenesis of tumors.
Journal Article
Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus.
TL;DR: Relatively large amounts of radioactive AFP, judged by relative intensity of AFP precipitation line on radioautography, were found in each of the liver cultures of the developing yolk sac, and AFP was observed in smaller amounts in almost all gastrointestinal tract cultures studied.
Journal ArticleDOI
The Role of Serum Alpha-Fetoprotein estimation in the Diagnosis and Management of Hepatocellular Carcinoma
TL;DR: There is preliminary evidence that changes in serum AFP may be a more accurate and sensitive way of determining the degree of response to treatment than conventional imaging procedures that rely on physical determination of tumor size.
Journal ArticleDOI
Dietary aflatoxins and liver cancer--a population based study in Kenya.
F. G. Peers,C. A. Linsell +1 more
TL;DR: The Murang'a district of the central province of Kenya was chosen primarily to check the feasilibity, methodology and general study design and there was no evidence to suggest that the frequency of liver cancer was higher here than elsewhere in East Africa.
Journal ArticleDOI
Hepatoid adenocarcinomas of the stomach. An analysis of seven cases.
Hiroshi Ishikura,Koji Kirimoto,Mikihiro Shamoto,Yuichi Miyamoto,Hiroshi Yamagiwa,Tetsuo Itoh,Miki Aizawa +6 more
TL;DR: The poor prognosis of the tumors may be attributed to these involvements as well as to production of AFP and presence of AAT/ACT, which have immunosuppressive and protease‐inhibitory properties, respectively.
References
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Journal Article
Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data.
TL;DR: The main findings reported by Tatarinov suggest that the arglobulin test is both more regular and more specific in hu man hepatomas than in experimentally induced tumors, at least in mice.
Journal ArticleDOI
Embryonal serum α-globulin in cancer patients: Diagnostic value
TL;DR: Sera of 308 patients, of whom 242 were suffering from various types of tumours and 66 from non‐cancerous diseases, were tested for the presence of αf‐globulin, and the reaction was positive in 17 out of 28 patients with primary cancer of the liver.
Journal ArticleDOI
Alpha-1 fetoglobulin in the diagnosis of human hepatoma.
TL;DR: Monospecific rabbit antiserum against a human fetoglobulin was tested by double-gel diffusion against coded serums of patients with hepatoma and other liver diseases and controls in Uganda.
Journal ArticleDOI
Occurrence of fetoprotein in patients with neoplasms and non-neoplastic diseases
TL;DR: The results show that fetoprotein appears in two types of tumors only: 1) in hepatocellular carcinoma, and 2) in malignant undifferentiated teratoma.
Journal Article
Association of Embryonic Antigens with Experimentally Induced Hepatic Lesions in the Rat
TL;DR: Short-term hepatic injury was produced in rats by single i.p. injections of N -dimethylnitrosoamine, carbon tetrachloride, and cadmium sulfate, or by partial hepatectomy, and the embryonic α 2 -glycoprotein was associated with all these lesions, whereas Antigen LA was specifically associated with rats bearing hepatocarcinomas.