Journal ArticleDOI
Acyclovir for the Prevention of Recurrent Herpes Simplex Virus Eye Disease
Kirk R. Wilhelmus,Roy W. Beck,Pamela S. Moke,Chandler R. Dawson,Bruce Barron,Daniel B. Jones,Herbert E. Kaufman,Natalie Kurinij,R. Doyle Stulting,Joel Sugar,Elisabeth J. Cohen,Robert A. Hyndiuk,Penny A. Asbell +12 more
TLDR
12 months of treatment with acyclovir reduces the rate of recurrent ocular HSV disease and orofacial HSV diseases and is most important for patients with a history of HSV stromal keratitis, since it can prevent additional episodes and potential loss of vision.Abstract:
Background Long-term treatment with antiviral agents has been shown to prevent recurrences of genital and orofacial herpes simplex virus (HSV) disease, but it is uncertain whether prophylactic treatment can prevent recurrences of ocular HSV disease. Methods We randomly assigned 703 immunocompetent patients who had had ocular HSV disease within the preceding year to receive 400 mg of acyclovir or placebo orally twice daily. The study outcomes were the rates of development of ocular or nonocular HSV disease during a 12-month treatment period and a 6-month observation period. Results The cumulative probability of a recurrence of any type of ocular HSV disease during the 12-month treatment period was 19 percent in the acyclovir group and 32 percent in the placebo group (P<0.001). Among the 337 patients with a history of stromal keratitis, the most common serious form of ocular HSV disease, the cumulative probability of recurrent stromal keratitis was 14 percent in the acyclovir group and 28 percent in the pla...read more
Citations
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Journal ArticleDOI
Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update
Asim V. Farooq,Deepak Shukla +1 more
TL;DR: The global incidence of HSV keratitis is roughly 1.5 million, including 40,000 new cases of severe monocular visual impairment or blindness each year, and relevant epidemiologic issues regarding HSV epithelial and stromal disease are discussed.
Journal ArticleDOI
Update on the Management of Infectious Keratitis
TL;DR: Future strategies to reduce the morbidity associated with infectious keratitis are likely to be multidimensional, with adjuvant therapies aimed at modifying the immune response to infection holding the greatest potential to improve clinical outcomes.
Journal ArticleDOI
LASIK complications: etiology, management, and prevention.
Samir A. Melki,Dimitri T. Azar +1 more
TL;DR: By examining the etiology, management, and prevention of these complications, the refractive surgeon may be able to improve visual outcomes and prevent vision-threatening problems.
Journal ArticleDOI
Herpes simplex Keratitis
Stephen B. Kaye,Anshoo Choudhary +1 more
TL;DR: Evidence now suggests that HSV-1 infection disrupts the normal equilibrium between angiogenic and anti-angiogenic stimuli leading to vascularisation in herpes simplex keratitis.
Journal ArticleDOI
Influence of preparation conditions on acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability.
Claudia Giannavola,Claudio Bucolo,Adriana Maltese,Donatella Paolino,Maria Angela Vandelli,Giovanni Puglisi,Vinecent H L Lee,Massimo Fresta +7 more
TL;DR: PEG-coated PLA nanospheres can be proposed as a potential ophthalmic delivery system for the treatment of ocular viral infections.
References
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K. K. Gordon Lan,David L. DeMets +1 more
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Journal ArticleDOI
Acyclovir: a decade later.
Richard J. Whitley,John W. Gnann +1 more
TL;DR: Acyclovir has become the most widely prescribe drug in the world and is likely to be a game-changer in the treatment of herpesvirus infection.
Journal ArticleDOI
Epidemiology of ocular herpes simplex. Incidence in Rochester, Minn, 1950 through 1982.
TL;DR: There were no seasonal trends in incidence, but rates increased with time, and age-adjusted rates by sex were comparable.
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