Aliskiren, a novel orally effective renin inhibitor, provides antihypertensive efficacy and placebo-like tolerability similar to an at1-receptor blocker in hypertensive patients
Reads0
Chats0
About:
This article is published in American Journal of Hypertension.The article was published on 2004-05-01 and is currently open access. It has received 22 citations till now. The article focuses on the topics: Aliskiren & Renin inhibitor.read more
Citations
More filters
Journal ArticleDOI
European guidelines on cardiovascular disease prevention in clinical practice (version 2012) : the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts).
Joep Perk,G. De Backer,Helmut Gohlke,Ian D. Graham,Zeljko Reiner,Monique Verschuren,Christian Albus,Pascale Benlian,G Boysen,Renata Cifkova,Christi Deaton,Shah Ebrahim,Miles Fisher,Giuseppe Germanò,Richard J. Hobbs,Arno W. Hoes,Sehnaz Karadeniz,Alessandro Mezzani,Eva Prescott,Lars Rydén,Martin Scherer,M Syvänne,Scholte op Reimer Wjm.,Christiaan Vrints,David R. Wood,José Luis Zamorano,Faiez Zannad +26 more
TL;DR: The ESC Guidelines and Expert Consensus Documents as mentioned in this paper summarize and evaluate all currently available evidence on a particular issue with the aim to assist physicians in selecting the best management strategies for a typical patient, suffering from a given condition, taking into account the impact on outcome, as well as the risk-benefit ratio of particular diagnostic or therapeutic means.
Journal ArticleDOI
Renin inhibition with aliskiren: where are we now, and where are we going?
TL;DR: The potential of renin inhibition must be viewed in the context of the remarkable efficacy of both angiotensin-converting enzyme (ACE) inhibition and angiotENSin receptor blockers (ARBs) and the therapeutic implications for both the renin inhibitor employed alone or the renIn inhibitor combined with an ACE inhibitor or ARB.
Journal ArticleDOI
Bio-functionalities of proteins derived from marine algae — A review
Kalpa W. Samarakoon,You-Jin Jeon +1 more
TL;DR: In this review, identified bioactivities and potentialities of marine algal protein sources will be discussed for future pharmaceutical, nutraceutical and cosmeceutical applications.
Journal ArticleDOI
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Ronald W. Sarver,Jeanette Peevers,Wayne L. Cody,Fred L. Ciske,Jim Dyer,S. Donald Emerson,Jeanne C. Hagadorn,Daniel D. Holsworth,Mehran Jalaie,Michael Kaufman,Michelle Mastronardi,Patrick I. McConnell,Noel A. Powell,John Quin,Chad A. Van Huis,Erli Zhang,Igor Mochalkin +16 more
TL;DR: High-throughput screening efforts identified a small molecule renin inhibitor with a core substituted diaminopyrimidine ring that could be useful for the treatment of hypertension and suggested molecular alterations to improve binding affinity from both thermodynamic and structural perspectives.
Journal Article
Aliskiren – an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension
TL;DR: Aliskiren is the first in a new class of orally active, non-peptide, low molecular weight renin inhibitors, and so far the only renin inhibitor that has progressed to phase III clinical trials.