Journal ArticleDOI
Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast.
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TLDR
Cosmetic results were lessened when the biopsy procedure included a wide resection of adjacent breast tissue or when theBiopsy scar was obvious, and increasing doses of external beam radiation were associated with greater degrees of retraction and fibrosis of the treated breast.Abstract:
In 31 cases of Stages I or II carcinoma of the breast treated by primary radiation therapy, the cosmetic results were analyzed with regard to the details of treatment. Three principal treatment factors were identified which influenced the cosmetic outcome: (1) the extent and location of the biopsy procedure, (2) the time/dose factors of the radiation therapy and (3) the technique of the radiation therapy. Cosmetic results were lessened when the biopsy procedure included a wide resection of adjacent breast tissue or when the biopsy scar was obvious. Increasing doses of external beam radiation were associated with greater degrees of retraction and fibrosis of the treated breast. All 6 patients who received 6000 rad by external beam had significant retraction and fibrosis while patients who received 5000 rad rarely showed significant changes. Local boost doses by interstitial implantation did not diminish the cosmetic outcome. All patients were treated using supervoltage equipment without bolus and skin changes secondary to treatment were infrequent. Seventeen patients developed localized areas of fibrosis and skin changes at the matchline between adjacent radiation fields. Recommendations are made for improved cosmetic results based on these findings.read more
Citations
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Journal ArticleDOI
Randomized Trial of Breast Irradiation Schedules After Lumpectomy for Women With Lymph Node-Negative Breast Cancer
Timothy J. Whelan,R. MacKenzie,Jim A. Julian,Mark Levine,W Shelley,Laval Grimard,Barbara Lada,Himu Lukka,Francisco Perera,Anthony Fyles,Ethan Laukkanen,Sunil P.P. Gulavita,Veronique Benk,Barbara Szechtman +13 more
TL;DR: The more convenient 22-day fractionation schedule appears to be an acceptable alternative to the 35-day schedule in reducing recurrence of invasive breast cancer.
Journal ArticleDOI
The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway
TL;DR: It was showed that superoxide dismutase and combined pentoxifylline-tocopherol treatment enables the process of established radiation-induced fibroatrophy to be greatly reduced or even reversed, both in clinical practice and animal experiments.
Journal ArticleDOI
Long-term radiation complications following conservative surgery (CS) and radiation therapy (RT) in patients with early stage breast cancer
Susan M. Pierce,Abram Recht,T. Lingos,Anthony Abner,Frank A. Vicini,Barbara Silver,Andrew G. Herzog,Jay R. Harris +7 more
TL;DR: The risk of significant complications following conservative surgery and radiation therapy for early stage breast cancer is low and brachial plexopathy, rib fracture, tissue necrosis, pericarditis, and second non-breast malignancies occurring in the treatment field among 1624 patients with earlyStage breast cancer between 1968 and 1985 is reported.
Journal ArticleDOI
The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer.
Abram Recht,Steven E. Come,I. C. Henderson,Rebecca Gelman,Barbara Silver,Daniel F. Hayes,Lawrence N. Shulman,Harris +7 more
TL;DR: This study suggests that for patients with stage I or II breast cancer who are at substantial risk for systemic metastases, it is preferable to give a 12-week course of chemotherapy followed by radiation therapy, rather than radiation therapy followed by chemotherapy.
Journal ArticleDOI
Factors influencing cosmetic results after conservation therapy for breast cancer
Marie E. Taylor,Carlos A. Perez,Karen J. Halverson,Robert R. Kuske,Gordon W. Philpott,Delia M. Garcia,Joanne E. Mortimer,Robert J. Myerson,Diane M. Radford,Carol Rush +9 more
TL;DR: Host, tumor, and treatment-related factors influencing cosmetic outcome are analyzed for patients receiving breast conservation treatment and it is found that improper orientation of tylectomy and axillary incisions and refinement in surgical/irradiation techniques will enhance the cosmetic results in breast conservation therapy.
References
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Journal ArticleDOI
Radiation therapy as initial treatment for early stage cancer of the breast wiithout mastectomy
Leonard R. Prosnitz,Ira S. Goldenberg,R. Andrew Packard,Martin B. Levene,Jay R. Harris,Samuel Hellman,Paul E. Wallner,Luther W. Brady,Carl M. Mansfield,Simon Kramer +9 more
TL;DR: It is the conclusion that mastectomy is not a necessary part of the treatment of small breast cancers, that radiation withoutmastectomy is an acceptable alternative with far superior cosmetic and functional results, and adjuvant chemotherapy should be considered particularly in stage II patients in view of their 40% relapse rate.
Journal ArticleDOI
A modified three-field technique for breast treatment
TL;DR: A modification of the treatment technique has reduced the dose to less than 140% of the prescribed dose over approximately 4 mm and improves the cosmetic results after radiation treatment of breast cancer.
Journal ArticleDOI
Radical mastectomy with parasternal and supraclavicular dissection for mammary carcinoma.
E Dahl-Iversen,T Tobiassen +1 more
Journal ArticleDOI
Conservative radical mastectomy (Patey's operation).
R. S. Handley,A. C. Thackray +1 more
Journal ArticleDOI
Treatment of carcinoma of the breast by radiation therapy.
TL;DR: Those patients who had excisional biopsy had a significantly lower incidence of local recurrence than did those in whom the tumor was left in situ and recommendations are made concerning axillary node sampling and adjuvant chemotherapy for patients treated by this technique.