Journal ArticleDOI
Antibody Response to Varicella-Zoster Virus after Natural or Vaccine-Induced Infection
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TLDR
Although the serum IgG antibody responses persisted for at least eight to 12 months (to date) after either form of infection, the antibody activity appeared to be four- to eight-fold higher after natural infection than after immunization.Abstract:
The development of serum and nasopharyngeal antibody responses to varicella-zoster virus (VZV) was studied in groups of children after naturally acquired varicella or after immunization with the Oka strain of live attenuated VZV vaccine administered in varying doses via respiratory inhalation or subcutaneous injection. Natural infection, subcutaneous immunization, and respiratory inhalation of large doses of VZV vaccine consistently resulted in the development of VZV-specific IgG antibody responses in serum. Although the serum IgG antibody responses persisted for at least eight to 12 months (to date) after either form of infection, the antibody activity appeared to be four- to eight-fold higher after natural infection than after immunization. Transient IgG antibody responses were observed in serum after respiratory inhalation of smaller doses of VZV vaccine. Natural infection, but not VZV vaccine, was associated with the development of serum and nasopharyngeal IgA responses to VZV in most subjects.read more
Citations
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Journal ArticleDOI
Varicella-zoster virus.
TL;DR: A live attenuated varicella vaccine (Oka/Merck strain) is now recommended for routine childhood immunization and passive antibody prophylaxis withvaricella-zoster immune globulin is indicated for susceptible high-risk patients exposed to variceella.
Journal ArticleDOI
Varicella and herpes zoster. Changing concepts of the natural history, control, and importance of a not-so-benign virus.
TL;DR: Patients at High Risk of Morbidity or Mortality from Varicella-Zoster Virus Recognition of the potential severity of varicella in immunocompromised patients dates from post-mortem studies of two...
Journal ArticleDOI
Live Attenuated Varicella Vaccine: Efficacy for Children With Leukemia in Remission
Anne A. Gershon,Sharon Steinberg,Lawrence D. Gelb,George J. Galasso,William Borkowsky,Philip LaRussa,Angelo Ferrara +6 more
TL;DR: Varicella vaccine was approximately 80% effective in preventing clinical varicella in children with leukemia and completely effective in protecting against severe varICElla in this high-risk group of children.
Journal ArticleDOI
Attenuation of the Vaccine Oka Strain of Varicella-Zoster Virus and Role of Glycoprotein C in Alphaherpesvirus Virulence Demonstrated in the SCID-hu Mouse
Jennifer F. Moffat,Leigh Zerboni,Paul R. Kinchington,Charles Grose,Hideto Kaneshima,Ann M. Arvin +5 more
TL;DR: These SCID-hu mouse experiments show that the clinical attenuation of the varicella vaccine can be attributed to decreased replication of V-Oka in skin and that tissue culture passage alone reduces the ability of VZV to infect human skin in vivo.
References
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Journal ArticleDOI
Varicella in children with cancer: Seventy-seven cases.
TL;DR: The results show that varicella is more severe in cancer patients on therapy than the general population or in patients who have completed therapy, but is not highly fatal.
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Serologic response to varicella-zoster membrane antigens measured by direct immunofluorescence.
Journal ArticleDOI
Protective effect of antibody to parainfluenza type 1 virus.
TL;DR: Adult and older children undergoing reinfection probably constitute an important source of acute respiratory disease in infants and children, and most older children and adults have serum neutralizing antibody to this virus.
Journal Article
Distribution of Poliovirus Antibody in Serum, Nasopharynx and Alimentary Tract Following Segmental Immunization of Lower Alimentary Tract with Poliovaccine
Pearay L. Ogra,David T. Karzon +1 more
TL;DR: Poliovirus antibody response in serum, nasopharynx and segments of the lower alimentary tract has been studied following immunization of the distal segment of the colon in twelve patients with double-barrel surgical eolostomy, characterized by the appearance of secretory γA antibody in the immunized segment of colon.