Antimicrobial susceptibilities of 1,730 Haemophilus influenzae respiratory tract isolates in Spain in 1998-1999.
Francesc Marco,Juan Garcı́a-de-Lomas,César García-Rey,Emilio Bouza,Lorenzo Aguilar,Carlos Fernández-Mazarrasa +5 more
TLDR
ABSTRACT A β-lactamase prevalence of 23% was found among 1,730Haemophilus influenzae isolates, and susceptibility was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime.Abstract:
A β-lactamase prevalence of 23% was found among 1,730 Haemophilus influenzae isolates. Ampicillin susceptibility was 70%, and 12% of β-lactamase-negative strains presented diminished susceptibility to ampicillin (BLNAR phenotype). Susceptibility of 90% was found for cefaclor and clarithromycin, whereas it was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime. Ciprofloxacin-resistant (0.1%) and β-lactamase-positive amoxicillin/clavulanate-resistant (BLPACR) phenotypes (0.1%) are anecdotal so far.read more
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Defining, treating and preventing hospital acquired pneumonia: European perspective.
TL;DR: This manuscript reviews in depth several controversial or new topics in HAP and VAP and defines 20 consensual points that may be useful for the development of future guidelines and to stimulate clinical research by lying out what is currently accepted and what is unknown or controversial.
Journal ArticleDOI
Respiratory infections caused by non-typeable Haemophilus influenzae.
TL;DR: Several lines of evidence indicate that H. influenzae causes intracellular infection in the lower respiratory tract in chronic obstructive pulmonary disease and this observation has important implications in understanding the human immune response to the bacterium.
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Geographical and Ecological Analysis of Resistance, Coresistance, and Coupled Resistance to Antimicrobials in Respiratory Pathogenic Bacteria in Spain
Emilio Pérez-Trallero,Celia García-de-la-Fuente,César García-Rey,Fernando Baquero,Lorenzo Aguilar,Rafael Dal-Ré,Juan García-de-Lomas +6 more
TL;DR: It is highlighted the importance of different geographical frequencies of coresistance (associations of resistance to different drugs within the same species) and coupled resistance (association of resistance between different species) probably resulting from different local coselective events.
Journal ArticleDOI
Analysis of Invasive Haemophilus influenzae Infections after Extensive Vaccination against H. influenzae Type b
José Campos,Margarita Hernando,Federico Román,María Pérez-Vázquez,Belén Aracil,Jesús Oteo,Edurne Lázaro,Francisco J. de Abajo +7 more
TL;DR: In the post-Hib vaccination era, most invasive infections were due to noncapsulated strains and occurred in the extreme ages of life in patients with predisposing conditions, and the incidence of invasive H. influenzae infections, either encapsulated or not, did not increase.
Journal ArticleDOI
Ampicillin-Resistant Non-β-Lactamase-Producing Haemophilus influenzae in Spain: Recent Emergence of Clonal Isolates with Increased Resistance to Cefotaxime and Cefixime
Silvia García-Cobos,José Campos,Edurne Lázaro,Federico Román,Emilia Cercenado,César García-Rey,María Pérez-Vázquez,Jesús Oteo,Francisco J. de Abajo +8 more
TL;DR: The sequence of the ftsI gene encoding the transpeptidase domain of penicillin-binding protein 3 (PBP 3) was determined for 354 nonconsecutive Haemophilus influenzae isolates from Spain this article.
References
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