[Antitumor activity of Enterococcus faecalis FK-23 preparation against murine syngeneic tumors].
Kazutomo Ohasi,Katsuhito Satonaka,Tetsuro Yamamoto,Masatoshi Yamazaki,Sadao Kimura,Shigeru Abe,Hideyo Yamaguchi +6 more
TLDR
The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23, prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma and inhibited the growth of these carcinomas inoculated intradermally.Abstract:
The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice.read more
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Characterization of a bacteriocin produced by Enterococcus faecium GM‐1 isolated from an infant
J.H. Kang,M.S. Lee +1 more
TL;DR: The bacteriocin produced by the GM‐1 strain of Enterococcus faecium, isolated from the faeces of a newborn human infant, is partially characterized.
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Prophylactic effect of Enterococcus faecalis FK-23 preparation on experimental candidiasis in mice
Katsuhito Satonaka,Kazutomo Ohashi,Takao Nohmi,Tetsuro Yamamoto,Shigeru Abe,Katsuhisa Uchida,Hideyo Yamaguchi +6 more
TL;DR: The results suggested the potential usefulness of the FK‐23 preparation as a prophylactic agent for the management of patients with opportunistic fungal infections.
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Single administration of enterococcal preparation (FK-23) augments non-specific immune responses in healthy dogs
Hiromi Kanasugi,Takashi Hasegawa,Yoshitaka Goto,Hiromitsu Ohtsuka,Susumu Makimura,Tetsuro Yamamoto +5 more
TL;DR: A single administration of FK-23 appears to augment host resistance through stimulation of the non-specific immune responses in vivo, and cause a 1.4-fold increase in neutrophil phagocytosis when treated with the drug.
Journal ArticleDOI
Effect of lysed Enterococcus faecalis FK-23 (LFK) on allergen-induced peritoneal accumulation of eosinophils in mice.
TL;DR: There is some evidence to suggest that lysed Enterococcus faecalis FK‐23 (LFK) could relieve the clinical symptoms of pollinosis, but the mechanism responsible for this phenomenon remains unknown.
Journal ArticleDOI
Effects of the consumption of heat-killed Enterococcus faecalis EC-12 preparation on microbiota and metabolic activity of the faeces in healthy adults
TL;DR: The effects of the consumption (200 mg/day) of heat-killed Enterococcus faecalis EC-12 preparation (EC-12) for 14 days on microbiota and metabolic activity of the faeces were studied in eight healthy volunteers.