Journal ArticleDOI
Automated Fluorescence Polarization Immunoassay for Monitoring Vancomycin
TLDR
The FPIA assay can measure as little as 0.6 mg/L of vancomycin and is free of interferences from hemolysis, lipemia, bilirubin, and changes in protein concentration.Abstract:
SummaryWe have extended fluorescence polarization immunoassay (FPIA) technology for the measurement of drugs to include the complex amphoteric glycopeptide antibiotic vancomycin (molecular weight, 1,449). Fluorescein-labeled vancomycin was employed as a tracer, and antisera specific for vancomycin wread more
Citations
More filters
Journal ArticleDOI
Clinical pharmacokinetics of vancomycin.
TL;DR: The disposition of vancomycin in paediatric and geriatric patients appears to be primarily related to the degree of renal function, however, there is some evidence of altered tissue binding and/or tissue distribution in geriatrics patients.
Journal ArticleDOI
Treatment of Asymptomatic Clostridium difficile Carriers (Fecal Excretors) with Vancomycin or Metronidazole: A Randomized, Placebo-controlled Trial
Stuart Johnson,Scott R. Homann,K M Bettin,K M Bettin,Judith N. Quick,Judith N. Quick,Connie Clabots,Connie Clabots,Lance R. Peterson,Lance R. Peterson,Dale N. Gerding,Dale N. Gerding +11 more
TL;DR: In this article, vancomycin and metronidazole were compared for eradication of asymptomatic Clostridium difficile fecal excretion.
Journal Article
Treatment of Asymptomatic Clostridium difficile Carriers (Fecal Excretors) with Vancomycin or Metronidazole
Stuart Johnson,Scott R. Homann,K M Bettin,Judith N. Quick,Connie Clabots,Lance R. Peterson,Dale N. Gerding +6 more
TL;DR: Although treatment with vancomycin is temporarily effective, it is associated with a significantly higher rate of C. difficile carriage 2 months after treatment and is not recommended, and treatment with metronidazole is not effective.
Journal ArticleDOI
Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients.
C. Lamer,V de Beco,Paul Soler,S Calvat,J. Y. Fagon,Marie Christine Dombret,R Farinotti,Jean Chastre,C Gibert +8 more
TL;DR: The results suggest that the vancomycin distribution includes the ELF of the lower respiratory tract at a concentration that is dependent upon the levels in blood and the alveolar capillary membrane protein permeability.
Journal ArticleDOI
Vancomycin pharmacokinetics in patients with various degrees of renal function.
Keith A. Rodvold,Robert A. Blum,James H. Fischer,H. Z. Zokufa,John C. Rotschafer,Kent B. Crossley,Louise J. Riff +6 more
TL;DR: The influence of age, protein binding, and renal function on the pharmacokinetics of intravenous vancomycin was evaluated in 37 adult patients with various degrees of renal function and it was found that age did not significantly improve these correlations once CLCR was included.