Patent
Benzopyran and benzothiopyran derivatives
TLDR
In this paper, the authors described the compositions and methods of use of benzopyranone and benzothiopyrinone compounds with adrenergic and serotonergic activity.Abstract:
The invention relates to benzopyranone and benzothiopyranone compounds, compositions and methods of use which have adrenergic and serotonergic activity.read more
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Transdermal delivery of alpha adrenoceptor blocking agents
TL;DR: A transdermal patch for the delivery of Compound IV having the formula: ##STR1## to the skin of a patient is described in this paper.The patch comprises a backing layer, a drug depot comprising compound IV and a permeation enhancer composition.
Patent
Use of alpha-1c specific compounds to treat benign prostatic hyperplasia
TL;DR: In this article, the subject invention provides a method of treating benign prostatic hyperplasia or inhibiting contraction of a prostate tissue in a subject in need thereof which comprises administering to the subject a therapeutically effective amount of an α1C antagonist which binds to a human α 1C adrenergic receptor with a binding affinity greater than 50-fold higher than the binding affinity with which the α 1c antagonist binds to human α1b adrenergic receptors, provided that the α1c antagonist is not 2,6-Dimethyl-4-(4-nitrophen
Patent
Therapeutic heterocyclic compounds
Edward Pierson,Sohn Daniel,Markus Haeberlein,Timothy Wayne Davenport,Chapdelaine Marc,Horchler Carey,John P. McCauley +6 more
TL;DR: In this article, a compound having the formula (I) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders.
Patent
Use of selective antagonists of the .alpha.1b-adrenergic receptor for improvement of sexual dysfunction
TL;DR: In this article, a method of identifying compounds that are useful for the preparation of sexual dysfunction in males and females is presented. But the method is not suitable for the treatment of sexual disorders in females.
Patent
Gamma-aminoamide modulators of chemokine receptor activity
TL;DR: In this paper, the present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined, which are useful as modulators of chemokine receptor activity.
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Patent
Therapeutic use of serotonin-antagonists
TL;DR: In this paper, the use of a compound of formula A-B-C-D where either A is a monocyclic, bicyclic or heter-cyclic residue, B is -CO- or SO2-, C is -O- or -NH or a bond, and D is a heterocylic residue was described.
Patent
Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
TL;DR: In this article, the authors describe compounds of formula (I) which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. But they do not specify the type of carrier.
Patent
Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
TL;DR: There are disclosed compounds of the formula (I) ##STR1## wherein R1 is 1-adamantyl, 3-methyl-1-amide, 1-amide-3-noradamide, unsubstituted or substituted-2-indolyl, 2-benzofuranyl, and 3-benzinofuran, where the substituents are selected from lower alkyl, lower alkoxy and halo.
Patent
Derivatives of 2-aminopyrimidine-4-carboxamide, their preparation and therapeutic use
TL;DR: In this article, a general formula of general formula (I) is defined, in which n represents the number 2, 3, 4 or 5, p represents the numbers 0 or 1, R1 represents a hydrogen atom or a methyl group, Xm represents one or more atoms or groups chosen from the following: hydrogen, fluorine, chlorine, methoxy, isopropyl or cyclopropyclopropynyl, in the form of free bases or of addition salts with acids.
Patent
Phenylpiperazine derivatives and process for producing the same
Hiroyuki Nagano,Mitiro Takagi,Noboru Kubodera,Isao Matsunaga,Hiroyuki Nabata,Yasuhiro Ohba,Kazushige Sakai,Shun-Ichi Hata,Yasumi Uchida +8 more
TL;DR: In this article, the disclosure of compounds of the formula (wherein R 1 is a lower alkyl group, R 2, R 3 and R 4 are the same or different, represent a hydrogen atom, a halogen atom, an octogenoid, a lower alkoxy-carbonyl group or a trifluoromethyl group) or salts thereof, are disclosed, and two adjacent groups of R2, R3 and R4 may combine to form a methylenedioxy group.