Patent
Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
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In this article, the authors describe compounds of formula (I) which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. But they do not specify the type of carrier.Abstract:
This invention relates to compounds of formula (I) which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of formula (I) are useful inhibitors of cell proliferation.read more
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Compounds, compositions, and methods
Andrew Mcdonald,Gustave Bergnes,Bainian Feng,David J. Morgans,Steven David Knight,Kenneth A. Newlander,Dashyant Dhanak,Brook Christopher S +7 more
TL;DR: In this article, compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. But none of these compounds are suitable for treating cancer.
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PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?
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Dna-pk inhibitors
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TL;DR: In this paper, the authors presented a list of compounds useful as inhibitors of DNA-PK and provided pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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Therapeutic morpholino-substituted compounds
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References
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Journal ArticleDOI
Die Synthese von asymmetrisch substituierten o‐Hydroxyphenyl‐s‐triazinen
Heimo Dr Brunetti,C. E. Lüthi +1 more
TL;DR: In this article, the path of reaction is determined by the character of substituent R4 in 10, where the starting materials are discussed and the scope and limitations of these reactions and accessibility of starting materials is discussed.
Journal ArticleDOI
Synthesis and anti-platelet activity of some 2-(dialkylamino)chromones
Mauro Mazzei,Alessandro Balbi,Giorgio Roma,Mario Di Braccio,Giuliana Leoncini,Enrica Buzzi,M. Maresca +6 more
TL;DR: Substituted 2-(diethylamino) or 2-(ethylamino)-chromones were obtained from the reaction of suitable phenols with the reagent ethyl N,N-diethyl- or N-ethylmalonamate/POCl3 (2a or 2b).
Journal ArticleDOI
Synthesis of 2‐aminochromones. Studies on the nucleophilic displacement of sulphinyl and sulphonyl groups in the 2‐position of 5,8‐dimethoxychromone
J. R. Bantick,J. L. Suschitzky +1 more
TL;DR: In this paper, the synthesis of a number of N-substituted 2-amino-5,8-dimethoxychromones (1) by replacement of the sulphoxide group in 2-ethylsulphinyl-5 8-dimethyloxychromone (5a) with the appropriate amine is described.
Journal Article
Utility of selected line (SEA) of the Japanese quail (Coturnix coturnix japonica) for the discovery of new anti-atherosclerosis drugs.
Day Ce,Stafford Ww,Schurr Pe +2 more
TL;DR: The male of the selected line of Japanese quail was shown to be an economical and practical animal model for the screening of anti-atherosclerosis drugs; it is small, inexpensive, and readily develops atherosclerosis.
Book ChapterDOI
Reaction patterns of intimal mesenchyme to injury, and repair in atherosclerosis.
M. Daria Haust,M. Daria Haust +1 more
TL;DR: The role of the arterial wall itself in the inception and progression of atherosclerotic lesions had been disregarded for many decades, but by taking into consideration the factors of arterIAL wall at least some of the remaining problems can be solved.