Journal ArticleDOI
Bowel perforation in Hirschsprung's disease
Reads0
Chats0
TLDR
Hirschsprung's disease should be a prime differential consideration in a young infant with penumoperitoneum caused by distal bowel perforation.Abstract:
A review of the medical records of 45 infants less than 1 year old with Hirschsprung's disease identified two (4.4%) who presented with bowel perforation. A literature survey was done to evaluate the relationship between bowel perforation of the bowel early in the course of Hirschsprung's disease indicates that: the infant under 4 months old is at the greatest risk; the majority of cases (62%) were associated with long-segment or total colonic Hirschsprung's disease; the most common sites of perforation were the proximal colon (68%) and appendix (17%); in cases with a short or intermediate length of aganglionic bowel, the perforation was proximal to or at the site of transition, but in 84% of infants with total colonic aganglionosis the perforation was situated in aganglionic bowel. Hirschsprung's disease should be a prime differential consideration in a young infant with penumoperitoneum caused by distal bowel perforation.read more
Citations
More filters
Journal ArticleDOI
Hirschsprung's Disease: Evaluation of Mortality and Long-term Function in 260 Cases
TL;DR: Bowel habits improved with time and were considered normal in 58% of patients at less than 5 years of follow-up and in 88% of Patients at more than 15 years of following-up.
Journal ArticleDOI
Hirschsprung disease — integrating basic science and clinical medicine to improve outcomes
TL;DR: Basic science discoveries are linked to clinical manifestations of Hirschsprung disease, including partial penetrance, enterocolitis and genetics, and insights into disease mechanisms that might lead to new prevention, diagnostic and treatment strategies are described.
Journal ArticleDOI
Enterocolitis associated with Hirschsprung's disease: a clinical-radiological characterization based on 168 patients.
Essam A. Elhalaby,Arnold G. Coran,Arnold G. Coran,Caroline E. Blane,Caroline E. Blane,Ronald B. Hirschl,Ronald B. Hirschl,Daniel H. Teitelbaum,Daniel H. Teitelbaum +8 more
TL;DR: The authors conclude that HEC can be characterized as abdominal distension and explosive diarrhea associated with the intestinal cutoff sign and the occurrence of explosive diarrhea in any patient with HD is suggestive of H EC, even in the absence of systemic symptoms, and should be treated to avoid the morbidity and potential mortality of HEC.
Journal ArticleDOI
Enterocolitis associated with Hirschsprung's disease: A clinical histopathological correlative study
Essam A. Elhalaby,Daniel H. Teitelbaum,Daniel H. Teitelbaum,Arnold G. Coran,Arnold G. Coran,Kathleen P. Heidelberger,Kathleen P. Heidelberger +6 more
TL;DR: This study showed that histopathologic findings of HEC appear to predict the clinical development, but not the severity, of future episodes of clinical HEC; a histological grade of > or = II (> or = 2 crypt abscesses per high power field) should raise suspicion for subsequent occurrence of Hec; and contrary to what is generally thought, histopathological changes of H EC occur in both ganglionic and aganglionic segments.
Journal ArticleDOI
Enterocolitis in Hirschsprung's disease
TL;DR: The risk of enterocolitis was increased in girls, in patients with associated Down's syndrome, those with a family history of HD, and those managed by an endorectal pull-through procedure, as well as in patients treated for Hirschsprung's disease.
References
More filters
Journal ArticleDOI
Diagnosis of congenital megacolon: An analysis of 501 patients
Orvar Swenson,Orvar Swenson,Joseph O. Sherman,Joseph O. Sherman,John H. Fisher,John H. Fisher +5 more
TL;DR: A retrospective detailed review of the presenting signs and symptoms and hospital evaluation of 501 patients diagnosed as having congenital megacolon is presented.
Journal ArticleDOI
Congenital Megacolon (Hirschsprung's Disease)
TL;DR: For the past sixty years the term “Hirschsprung's disease” has been used to describe enlargement of the colon exclusive of megacolon due to demonstrable organic disease.