Patent
Calcium independent camp phosphodiesterase inhibitor antidepressant
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TLDR
In this article, the authors defined a class of antidepressant agents having formula (I), wherein R1 is a polycycloalkyl group, R2 is methyl or ethyl, X is O or NH, and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens.Abstract:
Antidepressant agents having formula (I), wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.read more
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Substituted 2-anilinopyrimidines useful as protein kinase inhibitors
TL;DR: The src-family protein kinase inhibitors as mentioned in this paper are selective inhibitors of protein kinases, and are of use in the prophylaxis and treatment of immune diseases, hyperproliferative disorders and other diseases in which inappropriate kinase action is believed to have a role.
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Catechol diethers as selective pde iv inhibitors
TL;DR: In this paper, a 4-substituted catechol diether compounds which are selective inhibitors of PDEIV type IV were used for the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases.
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5-Cyano-2-aminopyrimidine derivatives
TL;DR: Pyrimidines of formula (1) are described wherein Ar is an optionally substituted aromatic or heteroaromatic group; R 1 is a hydrogen atom or a straight or branched chain alkyl group, R 2 is a -X1-R3 group where X1 is a direct bond or a linker atom or group.
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Tri-substituted phenyl derivatives and processes for their preparation
TL;DR: In this article, selective phosphodiesterase IV inhibitors were proposed for the prophylaxis or treatment of inflammatory diseases, and they were used for the treatment of various inflammatory diseases.
Patent
Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
TL;DR: In this article, the authors present compounds of the formula I that selectively inhibit an isoenzyme of 3′:5′-cyclic AMP phosphodiesterase located in pulmonary smooth muscle tissue and inflammatory cells and are bronchodilatory or anti-inflammatory.
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4-(polyalkoxy-phenyl)-2-pyrrolidone ii
Ralph Schmiechen,Reinhard Horowski,Dieter Dr Palenschat,Gert Paschelke,Helmut Wachtel,Wolfgang Kehr +5 more
TL;DR: The pyrrolidones can be converted to the corresponding thiopyrrinidones by reaction with phosphorous pentasulfide in the presence of base in this article.
Patent
4-(Polyalkoxyphenyl)-2-pyrrolidones (II)
Ralph Schmiechen,Reinhard Horowski,Dieter Dr Palenschat,Gert Paschelke,Helmut Wachtel,Wolfgang Kehr +5 more
TL;DR: In this article, the pyrrolidones are converted to corresponding thiopyrrinidones in a conventional manner, e.g., by reaction with phosphorous pentasulfide in the presence of base.
Patent
7-Aminoazolo[1,5-a]-pyrimidines and fungicides containing these compounds
TL;DR: In this paper, Aminoazolo et al. defined the meaning of a pyrimidine as a compound with up to two double-bonded double-branching.
Patent
Aryl substituted nitrogen heterocyclic antidepressants
TL;DR: In this paper, the authors presented a 5-membered heterocyclic ring having one or two nitrogens. But they did not specify the structure of the ring. And they only used a polycycloalkyl group.
Patent
Amino-, mercapto- and -oxy-substituted-phenyl and -phenalkyl imidazoles
TL;DR: In this paper, the authors describe a class of compounds for combating Germatophyte infections, including Trichophyton rubrum and mentagrophytes, and yeast infections, especially Candida albicans, as well as bacterial and fungal infections.