Journal ArticleDOI
Centrilobular hepatic necrosis and acute renal failure in "solvent sniffers".
TLDR
Three teenagers with a history of drug abuse developed acute hepatic injury after the inhalation of Carbona® cleaning fluid, a commercial preparation that contains trichloroethylene.Abstract:
Three teenagers with a history of drug abuse developed acute hepatic injury after the inhalation of Carbona® cleaning fluid, a commercial preparation that contains trichloroethylene. Two o...read more
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Journal ArticleDOI
Sentinel Health Events (occupational): a basis for physician recognition and public health surveillance.
David D. Rutstein,Robert J. Mullan,Todd M. Frazier,William E. Halperin,James M. Melius,John P. Sestito +5 more
TL;DR: A Sentinel Health Event(SHE) is a preventable disease, disability, oruntimely death whose occurrence serves as a warning signal that the quality of preventable and/or therapeutic medical care may need to be improved.
Journal ArticleDOI
Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms.
Nachman Brautbar,John Williams +1 more
TL;DR: The most important message from this review is that laboratory testing that is commonly used by clinicians to detect liver toxicity may not be sensitive enough to detect early liver hepatotoxicity from industrial Solvents and new methodologies are being encouraged and utilized in the early recognition and diagnosis of hepatot toxicity for solvents.
Journal ArticleDOI
Trichloroethylene. I. An overview
TL;DR: This TCE overview provides a narrative survey of the reference literature, highlighting history, nomenclature, physical and chemical properties, manufacture, analysis, uses, metabolism, toxicology, carcinogenic potential, exposure routes, recommended standards, and conclusions.
References
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Journal Article
Carbon tetrachloride hepatotoxicity
TL;DR: The knowledge that hepatic triglyceride secretion involves a dual mechanism has provided a powerful new guide for the analysis of mechanisms underlying fatty liver disease, and a central requirement of this hypothesis must be that if over supply of fatty acids is to be invoked as a significant factor in the pathogenesis of fatty liver, then the oversupply must be of sufficient magnitude and duration.
Journal ArticleDOI
Pharmacology and toxicology of trichloroethylene: A critical review of the world literature
TL;DR: A review of the world literatute on trichloroethylene has revealed a general inadequacy in medical reports and the need for further studies if this compound is to remain in the medical armamentarium.
Journal ArticleDOI
Effects on experimental animals of long-term inhalation of trichloroethylene, carbon tetrachloride, 1,1,1-trichloroethane, dichlorodifluoromethane, and 1,1-dichloroethylene.
TL;DR: Histopathologic study revealed liver damage following continuous exposures to high levels of dichlorodifluoromethane, and to lower levels of carbon tetrachloride, and 1,1-dichloroethylene (189 mg/m3).
Journal ArticleDOI
Investigations into the effects of exposure to trichlorethylene in mechanical engineering.
TL;DR: Trichlorethylene (tri) is a solvent widely used in mechanical engineering, where it is employed mainly for cleansing and degreasing, and its main advantages are that it is non-inflammable; is an excellent degrease agent, and is relatively inexpensive.
Journal ArticleDOI
Trichloroethylene: A Review
TL;DR: Investigations on man and animals indicate that pure trichlorethylene has no severe effect on other systems of the body, and the balance of opinion is against a severe toxic effect on the liver, although individual cases of liver damage in industrial workers have been reported.
Related Papers (5)
SOLVENT SNIFFING Physiologic Effects and Community Control Measures for Intoxication from the Intentional Inhalation of Organic Solvents. II.
Edward Press,Alan K. Done +1 more