Chirality has become a central theme in scientific research and is an important task in the field of analytical chemistry. In the past few decades, demand for chiral recognition and separation has increased due to the importance of chirality in many fields such as pharmaceutics, chemical industry, agriculture, and biological and clinical analysis. A survey of the literature suggests that different spectroscopic methods are applied to achieve the analysis of chiral enantiomeric compounds. This article is intended to focus on chiral analysis and affords a brief overview on chiral analysis of enantiomeric compounds using different spectroscopic methods, such as fluorescence spectroscopy, mass spectrometry, and nuclear magnetic resonance spectroscopy. In this review, primarily the intensive studies of how chiral recognition is achieved and an updated view of the different strategies used up to recognize the chirality of enantiomeric compounds are discussed.

background or methods

CFTA, a New Efficient Agent for Determination of Absolute Configurations of Chiral Secondary Alcohols.

Recent Development on Spectroscopic Methods for Chiral Analysis of Enantiomeric Compounds

Enantiomers of cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate show stereo-specific inhibition for acetylcholinesterase and butyrylcholinesterase. For both inhibition reaction, (2S,4aR,8aS)-cis,cis-decahydro-2-naphthyl-N-n- butylcarbamate is more potent than (2R,4aS,8aR)-cis,cis-decahydro-2-naphthyl-N-n-butylcarbamate. Optically pure (2S,4aR,8aS)-(−)- and (2R,4aS,8aR)-(+)-cis,cis-decahydro-2-naphthols are resolved by the porcine pancreatic lipase-catalyzed acetylation of decahydro-2-naphthols with vinyl acetate. Absolute configurations and the enantiomeric excess values of (2S,4aR,8aS)-(−)- and (2R,4aS,8aR)-(+)-cis,cis-decahydro-2-naphthols are determined from the 19F NMR spectra of their Mosher's ester derivatives. We fail to resolve (2S,4aR,8aR)- and (2R,4aS,8aS)-trans,cis-decahydro-2-naphthols from the porcine pancreatic lipase-catalyzed acetylation of decahydro-2-naphthols with vinyl acetate. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:330–339, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20394

background

Stereo‐specific inhibition of acetyl‐ and butyryl‐cholinesterases by enantiomers of cis,cis‐decahydro‐2‐naphthyl‐N‐n‐butylcarbamate

Chemistry indexing and abstracting service

CFTA, a New Efficient Agent for Determination of Absolute Configurations of Chiral Secondary Alcohols.

Citations

Recent Development on Spectroscopic Methods for Chiral Analysis of Enantiomeric Compounds

Stereo‐specific inhibition of acetyl‐ and butyryl‐cholinesterases by enantiomers of cis,cis‐decahydro‐2‐naphthyl‐N‐n‐butylcarbamate

References

CFTA, a new efficient agent for determination ofabsolute configurations of chiral secondary alcohols