Y
Yoshio Takeuchi
Researcher at University of Toyama
Publications - 142
Citations - 1993
Yoshio Takeuchi is an academic researcher from University of Toyama. The author has contributed to research in topics: Alkyl & Fluorine-19 NMR. The author has an hindex of 24, co-authored 142 publications receiving 1906 citations. Previous affiliations of Yoshio Takeuchi include University of Münster & Tohoku University.
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Journal ArticleDOI
A Fundamentally New Approach to Enantioselective Fluorination Based on Cinchona Alkaloid Derivatives/Selectfluor Combination
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(R)- and (S)-3-Fluorothalidomides: Isosteric Analogues of Thalidomide
TL;DR: It was shown that the (S-isomer) was found to be more active than both the (R)-isomer and the racemic thalidomide in lipopolysaccharide-induced TNF-α production enhancement produced from human peripheral blood lymphocytes cultivated in vitro.
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N-Fluoro-3-cyclohexyl-3-methyl-2,3- dihydrobenzo[1,2-d]isothiazole 1,1-Dioxide: An Efficient Agent for Electrophilic Asymmetric Fluorination of Enolates.
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A novel and efficient synthesis of 3-fluorooxindoles from indoles mediated by Selectfluor.
TL;DR: Treatment of several 3-substituted indoles, including derivatives of tryptophan and serotonin, with commercially available Selectfluor in acetonitrile/water furnished 3- submerged indoles obtained are sterically similar to both oxindoles and 3-hydroxyoxindoles, and should be useful as probes for investigating the enzymatic mechanism of indole biosynthesis and metabolism.
Journal ArticleDOI
Synthesis and biological activities of fluorinated chalcone derivatives
Chika Nakamura,Nobuhide Kawasaki,Hideki Miyataka,Ezhuthachan Jayachandran,In Ho Kim,Kenneth L. Kirk,Takeo Taguchi,Yoshio Takeuchi,Hitoshi Hori,Toshio Satoh +9 more
TL;DR: 6-Fluoro-3,4-dihydroxy-2',4'-dimethoxy chalcone was the most effective compound in the in vitro assay using a human cancer cell line panel (HCC panel) consisting of 39 systems.