Journal ArticleDOI
Changes in Blood Glucose and Plasma Insulin after Intravenous Galactose in Human Injury
TLDR
It is concluded that in most subjects after injury hepatic glucose release after galactose administration is not suppressed despite hyperglycaemia.Abstract:
1. The increase in blood glucose after intravenous galactose was measured at 6−8 h and 14 days after hip replacement (14 patients) and accidental injury (14 patients). 2. After hip replacement there was a greater rise of glucose after galactose on the day of the operation than on recovery, despite basal hyperglycaemia. This earlier period was also associated with inappropriately low insulin concentrations for the prevailing glucose concentration, and hyperketonaemia (13 out of 14 patients). 3. After accidental injury patients with initial hyperketonaemia (nine out of 14) also had a greater rise of blood glucose after galactose than on recovery and had relative insulin deficiency; in contrast those who were initially normoketonaemic (five out of 14) showed a rise in glucose comparable with that after recovery and basal insulin concentrations more appropriate to the existing glucose concentration. 4. It is concluded that in most subjects after injury hepatic glucose release after galactose administration is not suppressed despite hyperglycaemia.read more
Citations
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Journal ArticleDOI
Effects of Ingested Steak and Infused Leucine on Forelimb Metabolism in Man and the Fate of the Carbon Skeletons and Amino Groups of Branched-Chain Amino Acids
TL;DR: The observations indicate that both ingested steak and infused leucine produce important changes in the selection of respiratory fuels by the humanForelimb, that BCOA is preferentially oxidized rather than released from human limb tissues, and that glutamine, not alanine, is the major amino group carrier leaving the forelimb both after a protein meal and after leucin administration.
Journal ArticleDOI
Relationship between the basal blood alanine concentration and the removal of an alanine load in various clinical states in man.
TL;DR: The results show that the metabolic response to anAlanine load and the ability of the body to remove it alter with change in physiological state, and that the hypoalaninaemia after surgery and in diabetes is related to an increased removal of intravenous alanine, whereas that during starvation is not.
Journal ArticleDOI
The removal of infused leucine after injury, starvation and other conditions in man.
TL;DR: The blood concentration of leucine as significantly increased by surgery, starvation and accidental injury, and decreased in cirrhosis, and it tended to increase in diabetes and was unaffected by muscular dystrophy.
Journal ArticleDOI
Sex and surgical stress.
TL;DR: The endocrine and metabolic response to anaesthesia and surgery was studied in men and eight women undergoing elective total hip replacement using buprenorphine as the intra‐ and postoperative analgesic and to the neuroendocrine effects of opiate agonists and partial agonists.
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