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Institution

Guy's Hospital

HealthcareLondon, Southwark, United Kingdom
About: Guy's Hospital is a healthcare organization based out in London, Southwark, United Kingdom. It is known for research contribution in the topics: Breast cancer & Population. The organization has 12130 authors who have published 15303 publications receiving 646009 citations.


Papers
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Journal ArticleDOI
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.

8,513 citations

Journal ArticleDOI
14 Apr 2005-Nature
TL;DR: BRCA1 or BRCA2 dysfunction unexpectedly and profoundly sensitizes cells to the inhibition of PARP enzymatic activity, resulting in chromosomal instability, cell cycle arrest and subsequent apoptosis, illustrating how different pathways cooperate to repair damage.
Abstract: BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes predispose to breast and other cancers. Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in base excision repair, a key pathway in the repair of DNA single-strand breaks. We show here that BRCA1 or BRCA2 dysfunction unexpectedly and profoundly sensitizes cells to the inhibition of PARP enzymatic activity, resulting in chromosomal instability, cell cycle arrest and subsequent apoptosis. This seems to be because the inhibition of PARP leads to the persistence of DNA lesions normally repaired by homologous recombination. These results illustrate how different pathways cooperate to repair damage, and suggest that the targeted inhibition of particular DNA repair pathways may allow the design of specific and less toxic therapies for cancer.

5,650 citations

Journal ArticleDOI
TL;DR: It is now possible to establish the antioxidant activities of plant-derived flavonoids in the aqueous and lipophilic phases, and to assess the extent to which the total antioxidant potentials of wine and tea can be accounted for by the activities of individual polyphenols.

4,076 citations

Journal ArticleDOI
01 Nov 1996-Cell
TL;DR: Mice have been generated that are transgenic for the 5' end of the human HD gene carrying CAG/polyglutamine repeat expansion that exhibits many of the features of HD, including choreiform-like movements, involuntary stereotypic movements, tremor, and epileptic seizures.

3,056 citations

Journal ArticleDOI
26 Jun 1997-Nature
TL;DR: The severe obesity found in two severely obese children who are members of the same highly consanguineous pedigree provides the first genetic evidence that leptin is an important regulator of energy balance in humans.
Abstract: The extreme obesity of the obese (ob/ob) mouse is attributable to mutations in the gene encoding leptin, an adipocyte-specific secreted protein which has profound effects on appetite and energy expenditure We know of no equivalent evidence regarding leptin's role in the control of fat mass in humans We have examined two severely obese children who are members of the same highly consanguineous pedigree Their serum leptin levels were very low despite their markedly elevated fat mass and, in both, a homozygous frame-shift mutation involving the deletion of a single guanine nucleotide in codon 133 of the gene for leptin was found The severe obesity found in these congenitally leptin-deficient subjects provides the first genetic evidence that leptin is an important regulator of energy balance in humans

2,912 citations


Authors

Showing all 12148 results

NameH-indexPapersCitations
Rob Knight2011061253207
Michael Marmot1931147170338
James M. Wilson150101078686
Marvin Johnson1491827119520
Timothy J. Key14680890810
John L.R. Rubenstein14040561860
Jürg Tschopp14032886900
Christopher D.M. Fletcher13867482484
David A. Jackson136109568352
Peter Brown12990868853
David P. Lane12956890787
Marc C. Hochberg12769187268
Roger Williams122145572416
John C. Chambers12264571028
Anthony Howell12071455075
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202227
2021187
2020176
2019160
2018150