Journal ArticleDOI
Characteristics of an established cell line of retinoblastoma.
Ted W. Reid,Daniel M. Albert,Alan S. Rabson,Paul Russell,Joe Craft,Elizabeth W. Chu,Tommie Sue Tralka,Janice L. Wilcox +7 more
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This article is published in Journal of the National Cancer Institute.The article was published on 1974-08-01. It has received 342 citations till now. The article focuses on the topics: Retinoblastoma.read more
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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Stephen H. Friend,Stephen H. Friend,René Bernards,Snezna Rogelj,Robert A. Weinberg,Joyce M. Rapaport,Daniel M. Albert,Thaddeus P. Dryja +7 more
TL;DR: The isolation of a complementary DNA segment that detects a chromosomal segment having the properties of the gene at this locus is described, which is expressed in many tumour types, but no RNA transcript has been found in retinoblastomas and osteosarcomas.
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Human retinoblastoma susceptibility gene: cloning, identification, and sequence
TL;DR: A gene encoding a messenger RNA (mRNA) of 4.6 kilobases, located in the proximity of esterase D, was identified as the retinoblastoma susceptibility (RB) gene on the basis of chromosomal location, homozygous deletion, and tumor-specific alterations in expression.
Journal ArticleDOI
Genetics of retinoblastoma
TL;DR: The genetic basis of retinoblastoma is reviewed and the alternative possibility is suggested that in the nonhereditary variant a single mutational step—possibly a small chromosome aberration—could be enough to produce a tumor.
Journal ArticleDOI
Expression of Cone-Photoreceptor–Specific Antigens in a Cell Line Derived from Retinal Tumors in Transgenic Mice
TL;DR: These cells also resemble neuronal cells with their spindlelike processes and should serve as a useful alternative in vitro model for the study of cone photoreceptor cell biology and associated diseases.
Journal Article
Neuronal differentiation of retinoblastoma cells induced by medium conditioned by human RPE cells.
TL;DR: The response of Y79 cells to RPE-conditioned medium indicates that factors secreted by RPE cells can act as inducers of neuronal differentiation in retinoblastoma cells and suggest that such factors may be of importance in the development and differentiation of the neural retina.