Journal ArticleDOI
Clinical outcomes of Ex Vivo liver resection and liver autotransplantation for hepatic alveolar echinococcosis
TLDR
It could be the most effective method to cure intractable hepatic alveolar echinococcosis if correct handling in operation and proper prevention of complications are performed and the long-term outcomes are still needed to be confirmed in longer follow-up.Abstract:
The effectiveness of liver autotransplantation for patients with partial hepatic alveolar echinococcosis was analyzed. We retrospectively studied 6 patients with hepatic alveolar echinococcosis who underwent liver autotransplantation in our hospital from 2008 to 2010. We also summarized the surgical indications of liver autotransplantation for hepatic alveolar echinococcosis and our experience in the management of postoperative complications of liver autotransplantation. Of 6 patients, 5 achieved good curative results, and one died of multiple organ failure caused by portal vein thrombosis. Main complications included postoperative bleeding, bile leak and small-for-size liver graft syndrome. Liver autotransplantation offers a new approach to cure hepatic alveolar echinococcosis with non-resectable lesions. It could be the most effective method to cure intractable hepatic alveolar echinococcosis if correct handling in operation and proper prevention of complications are performed. But the long-term outcomes are still needed to be confirmed in longer follow-up.read more
Citations
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Journal ArticleDOI
Ex Vivo Liver Resection and Autotransplantation for End-Stage Alveolar Echinococcosis: A Case Series.
H. Wen,J.-H. Dong,J.-H. Zhang,W.-D. Duan,J.-M. Zhao,Y.-R. Liang,Y.-M. Shao,X.-W. Ji,Q.-W. Tai,T. Li,H. Gu,Tuerhongjiang Tuxun,Y.-B. He,J.-F. Huang +13 more
TL;DR: This is the largest reported series of patients with end‐stage hepatic AE treated with liver autotransplantation and the technique requires neither organ donor nor postoperative immunosuppressant.
Journal ArticleDOI
Current interventional strategy for the treatment of hepatic alveolar echinococcosis
Dominique A. Vuitton,Amel Azizi,Carine Richou,Lucine Vuitton,Oleg Blagosklonov,Eric Delabrousse,Georges Mantion,Solange Bresson-Hadni +7 more
TL;DR: This article reviews the current respective indications of surgical, percutaneous and perendoscopic interventions in AE and proposes an integrative therapeutic strategy that is best adapted to alleviating the biliary complications that are common and life-threatening in AE patients.
Journal ArticleDOI
Novel techniques and preliminary results of ex vivo liver resection and autotransplantation for end-stage hepatic alveolar echinococcosis: A study of 31 cases.
Xianwei Yang,Yiwen Qiu,Bin Huang,Wentao Wang,Shu Shen,Xi Feng,Yong-Gang Wei,Jianyong Lei,Jichun Zhao,Bo Li,Tian-Fu Wen,Lu-Nan Yan +11 more
TL;DR: The manipulation details are discussed and reasonable indications for this promising technique are proposed, which requires neither an organ donor nor any postoperative immunosuppressant and relies on meticulous preoperative assessments and precise surgical manipulation.
Journal ArticleDOI
Ex vivo liver resection followed by autotransplantation to a patient with advanced alveolar echinococcosis with a replacement of the retrohepatic inferior vena cava using autogenous vein grafting: a case report and literature review.
TL;DR: Ex vivo liver resection followed by autotransplantation with a replacement of the retrohepatic IVC using autogenous vein grafting might be a useful surgical practice for advanced AE.
Journal ArticleDOI
The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study.
Ke-fei Chen,Youyin Tang,Rui Wang,Dan Fang,Junhua Chen,Yong Zeng,Bo Li,Tian-Fu Wen,Wentao Wang,Hong Wu,Ming-Qing Xu,Jia-Yin Yang,Yong-Gang Wei,Jiwei Huang,Jiaxin Li,Han-zhi Zhang,Xi Feng,Lunan Yan,Zheyu Chen +18 more
TL;DR: It is believed in that all stages of hepatic alveolar echinococcosis should take active surgical interventions, and radical hepatic resection should be considered as the first-choice treatment for early stage of alveolars echinOCoccosis, while palliative surgery is still helpful to relieve symptoms and improve the life quality for advanced patients.
References
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Journal ArticleDOI
Experience of liver transplantation for incurable alveolar echinococcosis: a 45-case European collaborative report.
Stéphane Koch,Solange Bresson-Hadni,Jean-Philippe Miguet,Jean-Pierre Crumbach,Michel Gillet,George-André Mantion,Bruno Heyd,Dominique-Angèle Vuitton,Anne Minello,Sabine Kurtz +9 more
TL;DR: This unique experience indicates that LT is feasible for life-threatening AE, and specific management is needed to optimize the results: earlier decision for LT in incurable symptomatic biliary AE, pre- and post-LT BZM therapy, meticulous pre-LT evaluation to identify extrahepatic extension, and an immunosuppressive regimen kept to a minimum.
Journal ArticleDOI
Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis
Zakiyah Kadry,E. C. Renner,L. M. Bachmann,L. M. Bachmann,Nicolas Attigah,Eberhard L. Renner,Rudolf W. Ammann,P.-A. Clavien +7 more
TL;DR: Alveolar echinococcosis is a rare disorder, which makes a comparison of different treatment modalities within a clinical trial difficult to perform, and data prospectively recorded over a period of 25 years were used to evaluate three therapeutic strategies: benzimidazole therapy alone, complete ‘curative’ resection followed by 2 years of adjuvant benzimdazole treatment.
Journal ArticleDOI
Should possible recurrence of disease contraindicate liver transplantation in patients with end-stage alveolar echinococcosis? A 20-year follow-up study†‡§
Solange Bresson-Hadni,Oleg Blagosklonov,Jenny Knapp,Jenny Knapp,Frédéric Grenouillet,Yasuhito Sako,Eric Delabrousse,Marie-Pascale Brientini,Carine Richou,Anne Minello,Anca-Teodora Antonino,Michel Gillet,Akira Ito,Georges Mantion,Dominique A. Vuitton +14 more
TL;DR: Using anti‐rEm18 or anti‐Em2plus Ab levels and the delayed acquisition of FDG‐PET images can improve the functional assessment of disease activity and the potential recurrence of disease should not be regarded as a contraindication to LT when AE is considered to be lethal in the short term.
Journal ArticleDOI
Ex situ resection techniques and liver autotransplantation: last resource for otherwise unresectable malignancy.
TL;DR: These two cases are the paradigm of the possibility of performing extreme salvage procedures after the failure of more conventional treatments, allowing improvement in survival and quality of life in a controversial clinical scenario.
Journal ArticleDOI
Initial clinical results of orthotopic liver transplantation for hepatic alveolar echinococcosis.
TL;DR: This study suggests that OLT is feasible for incurable AE of the liver and that this procedure ensures a good clinical outcome.