Open AccessJournal Article
Clinical Studies with Tubercidin Administered by Direct Intravenous Injection
TLDR
Tubercidin (NSC 56408), a cytotoxic antibiotic, was used in the treatment of 93 patients with various types of advanced neoplastic disease in a Phase I study to determine human toxicity.Abstract:
Summary Tubercidin (NSC 56408), a cytotoxic antibiotic, was used in the treatment of 93 patients with various types of advanced neoplastic disease in a Phase I study to determine human toxicity Significant toxicity was limited to the observation of nephrotoxicity in 18 cases and local irritation of veins in 12 Tumor response was suggested in only 3 cases, all of which were cases of primary carcinoma of the pancreasread more
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Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma
TL;DR: In spite of gastrointestinal side effects, streptozocin combined with fluorouracil appears to be a valuable treatment for advanced islet-cell carcinoma.
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Islet Cell Tumors: Current Concepts and Management
TL;DR: The pancreatic islet is composed of three types of cells of neural crest origin, each with distinct histochemical and electromicroscopic features and each type of cell may give rise to a beni-cell type.
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Quantitative Prediction of Drug Toxicity in Humans from Toxicology in Small and Large Animals
TL;DR: If the starting dose in Phase 1 clinical trials had been selected by calculating one-third of the toxic dose low (in mg/sq m) in the most sensitive large animal species, 5 of the 30 drugs would have produced significant toxicity in the first patient.
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Substrate selectivity, potential sensitivity and stoichiometry of Na+-nucleoside transport in brush border membrane vesicles from human kidney
TL;DR: The data suggest that Na(+)-nucleoside transport in the human renal brush-border membrane is an electrogenic process and that the kidney may play a role in the disposition and targeting of clinically important nucleoside analogs.
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Meaningful clinical classification of therapeutic responses to anticancer drugs.
TL;DR: With the enormous increase in the clinical use of drugs to control the growth of cancer, it becomes essential to develop an acceptable and meaningful terminology to describe the indications and therapeutic effectiveness of each agent or procedure.