Journal ArticleDOI
Comportamento nelle 24 ore della risposta insulinemica ad un costante e ripetuto carico di glucosio in soggetti normali
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TLDR
In this article, it was rilevato that la variazione diurna della tolleranza glicidica puo dipendere strettamente dalla durata del digiuno and non esiste un ritmo circadiano.Abstract:
La glicemia e l'insulina immunoreattiva (IRI) sono state misurate, nel corso delle 24 h, prima ed esattamente 1 h dopo glucosio, in soggetti sani cui venivano somministrati, dopo una notte di digiuno, tre carichi di glucosio (50 g p.o.) ad uguali intervalli di tempo, ovvero alle ore 8, 16 e 24. Il test era ripetuto tre giorni piu tardi, ma il primo carico di glucosio veniva somministrato alle ore 16, dopo 14 h di digiuno, e cosi via agli stessi intervalli di tempo. E stato rilevato che la variazione diurna della tolleranza glicidica puo dipendere strettamente dalla durata del digiuno e che non esiste un ritmo circadiano. Al contrario, la risposta insulinemica allo stimolo glicemico e sempre piu elevata al mattino. Tale comportamento potrebbe essere in accordo con l'ipotesi di una ritmica variazione della secrezione dell'insulina, indipendente dalla durata del digiuno ma collegata a fattori ancora sconosciuti.read more
Citations
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Journal ArticleDOI
Circadian rhythm of immunoreactive insulin under glycemic stimulus
TL;DR: The insulin response to oral glucose exhibits a cyclic pattern with a peak in the morning, which was unaltered by prolonging the period of caloric deprivation, and no clear pattern of cyclicity could be demonstrated in respect of insulin response.
Journal ArticleDOI
Chronobiological aspects of weight loss in obesity: effects of different meal timing regimens.
Sergio Sensi,Fabio Capani +1 more
TL;DR: Minimal changes of hormonal circadian rhythms were documented suggesting that the hypothalamus-hypophysis network is scarcely affected by meal timing, and weight loss did not vary in both short- and long-term protocol.
Journal ArticleDOI
Diurnal variations in insulin secretion and insulin sensitivity in aged subjects.
TL;DR: It is suggested that aged subjects may be less able to modulate the binding of insulin to its peripheral receptors in the course of the day because of the disappearance of diurnal variations in glucose tolerance and insulin secretion and sensitivity.
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The role of insulin-resistance and free fatty acids on diurnal variations in glucose response to glucagon stimulation
TL;DR: The higher blood glucose values found in the evening in spite of the higher insulin values may be due to an increased hepatic glucose release in response to glucagon, possibly due to a condition of hepatic resistance to insulin; however an impaired uptake of glucose by peripheral tissues cannot be excluded.
Journal ArticleDOI
I ritmi biologici in diabetologia
TL;DR: I numerosi parametri descritti in oltre mezzo secolo dall'introduzione del test 7' ~0, ~x.v. di glucosio s o di tolbutamide ~' ", Ia risposta insulinemiea ~ pill rapida e marcata al mattino che nel pomeriggio~, per garantirne la migliore riproducibiIitfi.
References
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Use of glucose oxidase, peroxidase, and o-dianisidine in determination of blood and urinary glucose
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Insulin Secretion in Response to Glycemic Stimulus: Relation of Delayed Initial Release to Carbohydrate intolerance in Mild Diabetes Mellitus*
TL;DR: An empirical "insulinogenic index," the ratio relating enhancement of circulating insulin to magnitude of corresponding glycemic stimulus, was used to compare the secretory capacities of respective groups and revealed that insulin release in normal subjects was proportionally more than twice as great.
Journal Article
Growth hormone secretion during sleep
TL;DR: In this paper, growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults, and the effects of 6-CNS-active drugs on sleep-related GH secretion were investigated.
Journal ArticleDOI
Growth hormone secretion during sleep
TL;DR: Altered hypothalamic activity associated with initiation of sleep results in a major peak of growth hormone secretion unrelated to hypoglycemia or changes in cortisol and insulin secretion.