Book ChapterDOI
Computer-Aided Predictions of Pseudoallergic Reactions to Plasma Substitutes: A Model Using HaemaccelR
C. Ohmann,Wilfried Lorenz,Madeleine Ennis,Yang Qin,R. Zaczyk,B. Schöning +5 more
- pp 410-420
TLDR
The reactions the authors are interested in are the allergic/pseudoallergic reactions to drugs that follow a similar clinical picture but have different initiating reaction mechanisms.Abstract:
The application of a drug or plasma substitute to a patient carries the risk of an unwanted and unexpected reaction. The reactions we are interested in are the allergic/pseudoallergic reactions to drugs. Both types follow a similar clinical picture but have different initiating reaction mechanisms. In allergic reactions specific antibodies (IgE) are involved whereas in pseudoallergic reactions the drug acts directly on the same cells (mast cells, basophils) without the involvement of antibodies (1).read more
Citations
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Journal ArticleDOI
Perioperative uses of histamine antagonists.
TL;DR: The authors recommend that this prophylaxis be given to the following groups of patients: those with a history of adverse reactions or history of allergy, patients undergoing surgery with a high risk of histamine release, elderly patients, and those with poor physical status due to underlying systemic diseases.
Book ChapterDOI
Controlled clinical trials and cross-sectional studies with plasma histamine measurements and histamine receptor antagonists: solving the problem of preoperative H1- + H2-prophylaxis by asking new questions?
Wilfried Lorenz,Helmut Sitter,Benno Stinner,Dan G. Duda,B. Kapp,B Gstrein,Dietz W,A. Doenicke,Wolfgang Dick +8 more
TL;DR: It is concluded that the reasons why Histamine release in anaesthesia and surgery is so much underreported and under-estimated include the present paradigms about plasma histamine levels and the "classical picture" of histamine release, which are no longer valid and need a re-assessment.
Journal ArticleDOI
Selection of variables using ‘independence bayes’ in computer‐aided diagnosis of upper gastrointestinal bleeding
TL;DR: The results of this study suggest that the selection of variables should be evaluated against the estimated true diagnostic accuracy obtained using all variables, and secondly that the results of a single selected sequence may be severely biased.
Book ChapterDOI
Computerunterstützte Vorhersage von pseudoallergischen Reaktionen auf Blutersatzmittel (Haemaccel)
TL;DR: In this paper, anamnestische Faktoren (z.B. Allergieanamnese, Geschlecht, Hauttest, Histaminfreisetzung aus basophilen Leukocyten) als nutzlich and zuverlassig fur eine Vorhersage nachgewiesen werden konnten.
References
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Journal Article
Statistical and knowledge-based approaches to clinical decision-support systems, with an application in gastroenterology
Journal Article
Comparison of discrimination techniques applied to a complex data set of head injured patients
D. M. Titterington,G. Murray,L. S. Murray,David Spiegelhalter,A. M. Skene,J. D. F. Habbema,G. J. Gelpke +6 more
TL;DR: In this paper, several techniques for discriminant analysis are applied to a set of data from patients with severe head injuries, for the purpose of prognosis, such that multidimensionality, continuous, binary and ordered categorical variables and missing data must be coped with.
Journal ArticleDOI
Comparison of Discrimination Techniques Applied to a Complex Data Set of Head Injured Patients
D. M. Titterington,G. Murray,L. S. Murray,David Spiegelhalter,A. M. Skene,J. D. F. Habbema,G. J. Gelpke +6 more
TL;DR: In this work, several techniques for discriminant analysis are applied to a set of data from patients with severe head injuries, for the purpose of prognosis.
Journal ArticleDOI
The measurement of performance in probabilistic diagnosis. III. Methods based on continuous functions of the diagnostic probabilities.
TL;DR: The measurement of performance in probabilistic diagnosis using methods based on continuous functions of the diagnostic probabilities and its application in medicine.
Journal ArticleDOI
Definition and Classification of the Histamine-Release Response to Drugs in Anaesthesia and Surgery: Studies in the Conscious Human Subject* **
TL;DR: The average histamine-release response was defined by clinical signs such as tachycardia and mild hypertension, scattered hives such as spots of erythema and wheals, respiratory symptoms in the laryngeal and nasal region, such as cough, narrowness in the throat, stuffy nose and sneezing and by pathological plasma histamine levels (>1 ng/ml.